دورية أكاديمية
The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms
| العنوان: | The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms |
|---|---|
| المؤلفون: | Leete, Pia, Mallone, Roberto, Richardson, Sarah, J, Sosenko, Jay, M, Redondo, Maria, J, Evans-Molina, Carmella |
| المساهمون: | Islet Biology Exeter Exeter, UK (IBEx), University of Exeter-Institute of Biomedical and Clinical Sciences Exeter, UK, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de diabétologie CHU Cochin, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Sorbonne Paris Cité (USPC), Hôpital Cochin AP-HP, Department of Medicine Miami, FL, USA (Diabetes Research Institute), University of Miami Leonard M. Miller School of Medicine (UMMSM)-University of Miami Coral Gables, Baylor College of Medicine (BCM), Baylor University, Departments of Medicine and Pediatrics Indianapolis, IN, USA, Indiana University School of Medicine, Indiana University System-Indiana University System-Herman B Wells Center for Pediatric Research Indianapolis, IN, USA -Roudebush VA Medical Center Indianapolis, IN, USA, This study was financially supported by the European Union’s Seventh Framework Programme PEVNET ( FP7/2007-2013) under grant agreement number 261441. The participants of the PEVNET consortium are described at http://www.uta.fi/med/pevnet/publications.htmlTest. Additional support was from a JDRF research grants awarded to the network of Pancreatic Organ Donors–Virus (nPOD-V) consortium (JDRF 25-2012-516 and JDRF-3-SRA-2017-492-A-N) and a JDRF Career Development Award (5-CDA-2014-221-A-N), an MRC Project Grant (MR/P010695/1) and project grant from Diabetes UK (16/0005480) all to SJR. This work was also supported by NIH grants R01 DK093954 and UC4 DK 104166 (to C.E.M.), U01 DK103180 (toM.R.), VA Merit Award I01BX001733 (to C.E.M.), a JDRF Strategic Research Agreement (2-SRA-2018-493-A-B), and gifts from the Sigma Beta Sorority, the Ball Brothers Foundation, the George and Frances Ball Foundation, and the Holiday Management Foundation, all to C.E.M. R.M. received grants from the JDRF (1-PNF-2014-155-A-V, 2-SRA-2016-164-Q-R), the Agence Nationale de la Recherche (ANR-2015-CE17-0018-01) and by the Innovative Medicines Initiative 2 Joint Undertaking (INNODIA, 115797), which receives support from the EU Horizon 2020 program, the European Federation of Pharmaceutical Industries and Associations, JDRF, and the Helmsley Charitable Trust., ANR-15-CE17-0018,TIBET,LA PRESSION ENVIRONNEMENTALE SUR UNE IMAGE ALTEREE DU SOI IMMUNITAIRE : VERS LA PREDICTION ET LA PREVENTION DU DIABETE DE TYPE 1(2015), European Project: 261441,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,PEVNET(2011) |
| المصدر: | ISSN: 1534-4827. |
| بيانات النشر: | HAL CCSD Current Medicine Group |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | C-peptide, β cell, Type 1 diabetes, Autoimmunity, Age, [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | International audience ; PURPOSE OF REVIEW:To explore the impact of age on type 1 diabetes (T1D) pathogenesis.RECENT FINDINGS:Children progress more rapidly from autoantibody positivity to T1D and have lower C-peptide levels compared to adults. In histological analysis of post-mortem pancreata, younger age of diagnosis is associated with reduced numbers of insulin containing islets and a hyper-immune CD20hi infiltrate. Moreover compared to adults, children exhibit decreased immune regulatory function and increased engagement and trafficking of autoreactive CD8+ T cells, and age-related differences in β cell vulnerability may also contribute to the more aggressive immune phenotype observed in children. To account for some of these differences, HLA and non-HLA genetic loci that influence multiple disease characteristics, including age of onset, are being increasingly characterized. The exception of T1D as an autoimmune disease more prevalent in children than adults results from a combination of immune, metabolic, and genetic factors. Age-related differences in T1D pathology have important implications for better tailoring of immunotherapies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30259209; info:eu-repo/grantAgreement/EC/FP7/261441/EU/Persistent virus infection as a cause of pathogenic inflammation in type 1 diabetes - an innovative research program of biobanks and expertise/PEVNET; inserm-01918835; https://inserm.hal.science/inserm-01918835Test; https://inserm.hal.science/inserm-01918835/documentTest; https://inserm.hal.science/inserm-01918835/file/Leete2018_Article_TheEffectOfAgeOnTheProgression.pdfTest; https://inserm.hal.science/inserm-01918835/file/Evans-Molina%20ms_clean.pdfTest; PUBMED: 30259209 |
| DOI: | 10.1007/s11892-018-1083-4 |
| الإتاحة: | https://doi.org/10.1007/s11892-018-1083-4Test https://inserm.hal.science/inserm-01918835Test https://inserm.hal.science/inserm-01918835/documentTest https://inserm.hal.science/inserm-01918835/file/Leete2018_Article_TheEffectOfAgeOnTheProgression.pdfTest https://inserm.hal.science/inserm-01918835/file/Evans-Molina%20ms_clean.pdfTest |
| رقم الانضمام: | edsbas.324C64D8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11892-018-1083-4 |
|---|