Spatial epidemiology of Japanese encephalitis virus and other infections of the central nervous system infections in Lao PDR (2003–2011): A retrospective analysis
| العنوان: | Spatial epidemiology of Japanese encephalitis virus and other infections of the central nervous system infections in Lao PDR (2003–2011): A retrospective analysis |
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| المؤلفون: | Julien Cappelle, Sayaphet Rattanavong, Paul N. Newton, Daniel M. Parker, Mayfong Mayxay, Sue J. Lee, Manivanh Vongsouvath, Audrey Dubot-Pérès |
| المساهمون: | Mahosot Hospital [Vientiane, Laos], University of Oxford, Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Health Sciences [Vientiane, Laos] (UHS), Mahidol University [Bangkok], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Mixte de Recherche d'Épidémiologie des maladies Animales et zoonotiques (UMR EPIA), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), University of California [Irvine] (UC Irvine), University of California (UC), This study was supported by the European Commission Innovate program (ComAcross project, grant no. DCI-ASIE/2013/315-047). The work of LOMWRU, PN and MM are funded by the Wellcome Trust of Great Britain, grant 106698/Z/14/Z. Travel to Lao PDR to support DMP for this research was obtained through a University of California Council on Research, Computing, and Libraries (CORCL) Faculty Grant., University of Oxford [Oxford], Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of California [Irvine] (UCI), University of California, Attardo, Geoffrey M, Bodescot, Myriam |
| المصدر: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, 2020, 14 (5), pp.e0008333. ⟨10.1371/journal.pntd.0008333⟩ PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (5), pp.e0008333. ⟨10.1371/journal.pntd.0008333⟩ PLoS neglected tropical diseases, vol 14, iss 5 PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008333 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, RC955-962, Dengue virus, Pathology and Laboratory Medicine, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Arctic medicine. Tropical medicine, Ethnicities, 2.2 Factors relating to the physical environment, Aetiology, Child, Eukaryota, Spatial epidemiology, 3. Good health, Épidémiologie, Medical Microbiology, Laos, Viral Pathogens, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Public aspects of medicine, Infection, Encephalitis, medicine.medical_specialty, Microbiology, 03 medical and health sciences, Clinical Research, Humans, Encephalitis, Japanese, Microbial Pathogens, Retrospective Studies, Demography, Spatial Analysis, Flaviviruses, Organisms, Public Health, Environmental and Occupational Health, Biology and Life Sciences, Encephalitis Virus, Dengue Virus, Japanese encephalitis, medicine.disease, 030104 developmental biology, Vector (epidemiology), Virus encéphalite japonaise, Population Groupings, Japanese Encephalitis Virus, Central Nervous System, RNA viruses, Bacterial Diseases, 0301 basic medicine, medicine.disease_cause, L73 - Maladies des animaux, Nervous System, Medical and Health Sciences, Central Nervous System Infections, Epidemiology, Medicine and Health Sciences, Trouble du système nerveux, Encephalitis Virus, Japanese, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Vaccines, Bacterial Infections, Cryptococcosis, Middle Aged, Biological Sciences, Infectious Diseases, Viruses, Lao People, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Anatomy, Pathogens, RA1-1270, Research Article, Adult, Infectious Disease Control, Adolescent, 030231 tropical medicine, Murine typhus, Typhus, Young Adult, Cryptococcose, Diagnostic Medicine, Tropical Medicine, Environmental health, medicine, Système nerveux central, business.industry, Fungi, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Neurosciences, Distribution spatiale, Cryptococcus, Good Health and Well Being, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Murine Typhus, Maladie infectieuse, People and Places, Japanese, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Rural area, business |
| الوصف: | Background Central nervous system (CNS) infections are important contributors to morbidity and mortality and the causative agents for ~50% patients are never identified. The causative agents of some CNS infections have distinct spatial and temporal patterns. Methodology/Principal findings Here we present the results of a spatial epidemiological and ecological analysis of CNS infections in Lao PDR (2003–2011). The data came from hospitalizations for suspected CNS infection at Mahosot Hospital in Vientiane. Out of 1,065 patients, 450 were assigned a confirmed diagnosis. While many communities in Lao PDR are in rural and remote locations, most patients in these data came from villages along major roads. Japanese encephalitis virus ((JEV); n = 94) and Cryptococcus spp. (n = 70) were the most common infections. JEV infections peaked in the rainy season and JEV patients came from villages with higher surface flooding during the same month as admission. JEV infections were spatially dispersed throughout rural areas and were most common in children. Cryptococcus spp. infections clustered near Vientiane (an urban area) and among adults. Conclusions/Significance The spatial and temporal patterns identified in this analysis are related to complex environmental, social, and geographic factors. For example, JEV infected patients came from locations with environmental conditions (surface water) that are suitable to support larger mosquito vector populations. Most patients in these data came from villages that are near major roads; likely the result of geographic and financial access to healthcare and also indicating that CNS diseases are underestimated in the region (especially from more remote areas). As Lao PDR is undergoing major developmental and environmental changes, the space-time distributions of the causative agents of CNS infection will also likely change. There is a major need for increased diagnostic abilities; increased access to healthcare, especially for rural populations; and for increased surveillance throughout the nation. Author summary Infections of the central nervous system (CNS) are important with regard to public health. However many CNS infections are never diagnosed. In this analysis we investigated spatial and temporal patterns in hospitalized patients with suspected CNS infections in Lao PDR. We found that patients were most likely to come from villages located along major roads and highways. Patients from remote areas may have more difficulty reaching healthcare facilities. The most commonly diagnosed infection in these patients was Japanese encephalitis virus (JEV). Patients with this disease came from locations that were optimal for the mosquito vectors that spread JEV, rural areas with surface water and during the rainy season. Our analyses suggest that CNS infections should be a priority for public health workers in the region. Diagnostic capabilities should be increased throughout the nation; surveillance efforts should be broadened; and efforts should be increased toward providing easy access to healthcare for rural and remote populations. |
| وصف الملف: | text; text/pdf; application/pdf |
| اللغة: | English |
| تدمد: | 1935-2727 1935-2735 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc15f5e42f583345045273414e4feb8Test http://agritrop.cirad.fr/595965Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ffc15f5e42f583345045273414e4feb8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19352727 19352735 |
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