دورية أكاديمية
Adverse Effects of Oseltamivir Phosphate Therapy on the Liver of LDLR 2/2 Mice Without Any Benefit on Atherosclerosis and Thrombosis
| العنوان: | Adverse Effects of Oseltamivir Phosphate Therapy on the Liver of LDLR 2/2 Mice Without Any Benefit on Atherosclerosis and Thrombosis |
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| المؤلفون: | Bocquet, Olivier, Wahart, Amandine, Sarazin, Thomas, Vincent, Elise, Schneider, Christophe, Fougerat, Anne, Gayral, Stéphanie, Henry, Aubéri, Blaise, Sébastien, Romier-Crouzet, Béatrice, Boulagnon, Camille, Jaisson, Stéphane, Gillery, Philippe, Bennasroune, Amar, Sartelet, Hervé, Laffargue, Muriel, Martiny, Laurent, Duca, Laurent, Maurice, Pascal |
| المساهمون: | Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital universitaire Robert Debré Reims (CHU Reims) |
| المصدر: | ISSN: 0160-2446 ; Journal of Cardiovascular Pharmacology ; https://hal.science/hal-03358077Test ; Journal of Cardiovascular Pharmacology, 2021, 77 (5), pp.660-672. ⟨10.1097/FJC.0000000000001002⟩. |
| بيانات النشر: | HAL CCSD Lippincott, Williams & Wilkins |
| سنة النشر: | 2021 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | oseltamivir phosphate, sialidase, atherosclerosis, thrombosis, liver, inflammation, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology |
| الوصف: | International audience ; Desialylation, governed by sialidases or neuraminidases, is strongly implicated in a wide range of human disorders, and accumulative data show that inhibition of neuraminidases, such as neuraminidases 1 sialidase, may be useful for managing atherosclerosis. Several studies have reported promising effects of oseltamivir phosphate, a widely used anti-influenza sialidase inhibitor, on human cancer cells, inflammation, and insulin resistance. In this study, we evaluated the effects of oseltamivir phosphate on atherosclerosis and thrombosis and potential liver toxicity in LDLR 2/2 mice fed with high-fat diet. Our results showed that oseltamivir phosphate significantly decreased plasma levels of LDL cholesterol and elastin fragmentation in aorta. However, no effect was observed on both atherosclerotic plaque size in aortic roots and chemically induced thrombosis in carotid arteries. Importantly, oseltamivir phosphate administration had adverse effects on the liver of mice and significantly increased messenger RNA expression levels of F4/80, interleukin-1b, transforming growth factor-b1, matrix metalloproteinase-12, and collagen. Taken together, our findings suggest that oseltamivir phosphate has limited benefits on atherosclero-sis and carotid thrombosis and may lead to adverse side effects on the liver with increased inflammation and fibrosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33760798; hal-03358077; https://hal.science/hal-03358077Test; https://hal.science/hal-03358077/documentTest; https://hal.science/hal-03358077/file/Manuscript_Bocquet_et_al.pdfTest; PUBMED: 33760798 |
| DOI: | 10.1097/FJC.0000000000001002 |
| الإتاحة: | https://doi.org/10.1097/FJC.0000000000001002Test https://hal.science/hal-03358077Test https://hal.science/hal-03358077/documentTest https://hal.science/hal-03358077/file/Manuscript_Bocquet_et_al.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.63F0F2C5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/FJC.0000000000001002 |
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