دورية أكاديمية
Rhizophora mucronata Lam., a halophyte from Mauritius Island, inhibits the entry of Zika virus in human cells (A549)- an in vitro and in silico analysis
| العنوان: | Rhizophora mucronata Lam., a halophyte from Mauritius Island, inhibits the entry of Zika virus in human cells (A549)- an in vitro and in silico analysis |
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| المؤلفون: | Sadeer, Nabeelah Bibi, Haddad, Juliano, Ezzat, Mohammed Oday, Desprès, Philippe, Abdallah, Hassan, Zengin, Gokhan, Alshamrani, Ibtesam Mohammad, Barnawi, Jameel, Khalid, Asaad, Abdalla, Ashraf, Le Van, Bao, El Kalamouni, Chaker, Mahomoodally, Mohamad Fawzi |
| المساهمون: | University of Mauritius, Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), University of Salahaddin-Erbil, Selçuk University = Selçuk Üniversitesi, King Saud University Riyadh (KSU), University of Tabuk, Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI), P.O. Box 2404, National Center for Research, Khartoum, Sudan, Umm Al-Qura University, Duy Tan University (DTU), North-West University Potchefstroom (NWU) |
| المصدر: | ISSN: 0739-1102. |
| بيانات النشر: | HAL CCSD STM, Behavioural Science and Public Health Titles |
| سنة النشر: | 2023 |
| المجموعة: | Université de la Réunion: HAL |
| مصطلحات موضوعية: | Mangrove plants, Zika virus, antiviral, cytotoxicity, docking, entry inhibitors, glycoprotein, [SDV]Life Sciences [q-bio], [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | International audience ; The recent appearance of Zika virus (ZIKV) in Brazil should serve as a wake-up call to international authorities, as it poses a threat to global public health. In the present study, we investigated whether a mangrove plant, Rhizophora mucronata Lam. (R. mucronata) collected in Mauritius, possesses anti-ZIKV activity at the non-cytotoxic doses. ZIKVMC-MR766NIID (ZIKVGFP) was used for assessing anti ZIKV activity. In silico docking (Autodock 4) and molecular simulation were performed on collected data. Using a recombinant ZIKV expressing reporter green fluorescent protein(GFP) protein, we discovered that fruit and root methanolic, decocted fruit and root extracts were effective inhibitors of ZIKV infection in human epithelial A549 cells at negligible cytotoxicity. The mechanisms by which such extracts prevented ZIKV infection are linked to the inability of the virus to attach to the host cell surface. The outcomes of this study were supported by the docking calculations in which some of the dominant compounds have shown high binding affinity against ZIKV. The scientific data gathered in this study might pave the way for the future development of possible R. mucronata inhibitors to combat ZIKV.f |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04514314; https://hal.univ-reunion.fr/hal-04514314Test |
| DOI: | 10.1080/07391102.2023.2167115 |
| الإتاحة: | https://doi.org/10.1080/07391102.2023.2167115Test https://hal.univ-reunion.fr/hal-04514314Test |
| رقم الانضمام: | edsbas.C5BF1427 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/07391102.2023.2167115 |
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