Podocyte Antigen Staining to Identify Distinct Phenotypes and Outcomes in Membranous Nephropathy: A Retrospective Multicenter Cohort Study
| العنوان: | Podocyte Antigen Staining to Identify Distinct Phenotypes and Outcomes in Membranous Nephropathy: A Retrospective Multicenter Cohort Study |
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| المؤلفون: | Hanna Debiec, Ashley Broughton, Michel Wauthier, Albert Hermant, Benoit Georges, Abdelhamid Lalaoui, Diego Castanares-Zapatero, Matthieu Lemaire, Fabienne Mestrez, Yves Pirson, Nicolas Hanset, Nada Kanaan, Gregory Van Ingelgem, Roxana Sava, Benoit Guillaume, Jean-Michel Pochet, Frédéric Debelle, Lionel Mazzoleni, Valentine Gillion, Michel Tintillier, Nicolas Cecere, Philippe Leroy, Jean-Claude Stolear, Gabriela Migali, Benjamin Seront, Pierre Ronco, Corinne Langen, Michele Muller, Georges Cornet, Arnaud Devresse, Guy Fomegne, Nathalie Demoulin, Yvan Philips, Charlotte Van Ende, Assma Ballout, Delphine Halleux, Nadejda Ranguelov, Pierre-Yves Decleire, Ahmed Goubella, Christine Hurtgen, Ralph Crott, Pauline Biller, Johann Morelle, An Van Audenhove, Philippe Durieux, Caroline Clerckx, Nathalie Godefroid, Dominique Becker, Charles Cuvelier, Selda Aydin, Hélène Munyentwali, Francois Reginster, Jean-Louis Christophe, Jean-Philippe Lengelé, René Cuvelier, Benoit Buysschaert, Joëlle Ghysen, Jean-Jacques Lafontaine, Jean-François Cambier, Eric Goffin, Fabrice Gankam, Agnès Dejardin, Olivier Mat, Laura Labriola, Jean Jamez, Jean-Pierre Cosyns, Gaetan Clerbaux, Pierre Bernis, Michel Jadoul, Miguel-Ange Guillen-Anaya, Gaëlle Gillerot, Marie Rommelaere, Bénédicte Vanderperren, Joseph Mbaba Mena, Alina Tirdea, Liesbeth Smets, Frédéric Houssiau, Zuzana Rihova |
| المساهمون: | UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Service de rhumatologie, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Cliniques Universitaires Saint-Luc [Bruxelles], Lille économie management - UMR 9221 (LEM), Université d'Artois (UA)-Université catholique de Lille (UCL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université Catholique de Louvain = Catholic University of Louvain (UCL), Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche Expérimentale et Clinique (IREC), ANR-17-CE17-0012,MNaims,Dissection moléculaire de la glomérulonéphrite extramembraneuse liée à PLA2R1: vers l'identification de nouveaux biomarqueurs cliniques(2017), UCL - SSS/IREC - Institut de recherche expérimentale et clinique |
| المصدر: | American journal of kidney diseases, Vol. 76, no. 5, p. 624-635 (2020) American Journal of Kidney Diseases American Journal of Kidney Diseases, 2020, 76 (5), pp.624-635. ⟨10.1053/j.ajkd.2020.04.013⟩ American journal of kidney diseases : the official journal of the National Kidney Foundation, (2020) |
| بيانات النشر: | W.B. Saunders, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Biopsy, 030232 urology & nephrology, glomerular disease, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Gastroenterology, Glomerulonephritis, Membranous, phospholipase A(2) receptor (PLA(2)R), 0302 clinical medicine, Medicine, thrombospondin type 1 domain-containing 7A (THSD7A), 030212 general & internal medicine, Kidney, immunostaining, medicine.diagnostic_test, Podocytes, nephrotic syndrome, Middle Aged, 3. Good health, medicine.anatomical_structure, Phenotype, Nephrology, Disease Progression, outcome, Female, Adult, medicine.medical_specialty, kidney biopsy, thrombospondin type 1 domain-containing 7A, 03 medical and health sciences, Membranous nephropathy, Internal medicine, Humans, cancer, Aged, Autoantibodies, Retrospective Studies, phospholipase A2 receptor, Lupus erythematosus, Staining and Labeling, business.industry, membranous nephropathy, Cancer, Retrospective cohort study, medicine.disease, podocyte antigen, business, Nephrotic syndrome, Kidney disease, Follow-Up Studies, Membranous nephropathy (MN), malignancy |
| الوصف: | Rationale & Objective Membranous nephropathy (MN) is characterized by the deposition of immune complexes along glomerular basement membranes. M-Type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), exostosin 1 and 2 (EXT1/2), and neural epidermal growth factor-like 1 protein (NELL-1) have been identified as established or potential podocyte antigens in MN. We investigated the association of podocyte antigen staining with MN clinical phenotype and outcomes. Study Design Multicenter retrospective cohort study. Setting & Participants 177 consecutive patients with MN unrelated to lupus erythematosus, identified after screening of 3,875 native kidney biopsies performed in the Belgian UCLouvain Kidney Disease Network from 2000 through 2018. Predictor Positive immunostaining for podocyte antigens on archived kidney biopsy samples. Outcomes Association with different phenotypes (baseline characteristics of patients and pathologic findings on kidney biopsy), time to cancer and to kidney failure. Analytical Approach Kaplan-Meier estimates and Cox regression analyses to assess time to cancer and kidney failure. Results 177 patients were followed up for a median of 4.0 (IQR, 1.3-8.0) years. Diagnosis of PLA2R-positive (PLA2R+), THSD7A+, and double-negative (PLA2R−/THSD7A−) MN was made in 117 (66.1%), 6 (3.4%), and 54 (30.5%) patients, respectively. Progression to kidney failure was similar in all groups. Although the number of patients with THSD7A+ MN was small, they showed a higher incidence (50%) and increased risk for developing cancer during follow-up (adjusted HR, 5.0 [95% CI, 1.4-17.9]; P = 0.01). 8% and 5% of patients with double-negative MN stained positively for EXT1/2 and NELL-1, respectively. Most patients with EXT1/2+ MN were women, had features of systemic autoimmunity, and showed glomerular C1q deposits. Limitations Retrospective design; small number of patients in the THSD7A group; lack of evaluation of immunoglobulin G subclasses deposition. Conclusions Our real-world data describe the relative prevalence of subgroups of MN and support the hypothesis that a novel classification of MN based on podocyte antigen staining may be clinically relevant. |
| اللغة: | English |
| تدمد: | 0272-6386 1523-6838 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a66f896ea57ecf01d832514c059cd7Test https://hdl.handle.net/2078.1/242467Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f5a66f896ea57ecf01d832514c059cd7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02726386 15236838 |
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