Calcific tendonitis of the rotator cuff: From formation to resorption
| العنوان: | Calcific tendonitis of the rotator cuff: From formation to resorption |
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| المؤلفون: | Frédéric Blanchard, Christelle Darrieutort-Laffite, Benoit Le Goff |
| المساهمون: | Sarcomes osseux et remodelage des tissus calcifiés - Phy-Os [Nantes - INSERM U1238] (Phy-Os), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bretagne Loire (UBL)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service de Rhumatologie [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), maurice, sandrine |
| المصدر: | Joint Bone Spine Joint Bone Spine, Elsevier Masson, 2017, Epub ahead of print. ⟨10.1016/j.jbspin.2017.10.004⟩ |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Pathology, medicine.medical_specialty, Shoulder, Tendonitis, Tendons, 03 medical and health sciences, Rotator Cuff, 0302 clinical medicine, Rheumatology, Apatites, medicine, Humans, Rotator cuff, Osteopontin, Apatite, 030203 arthritis & rheumatology, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, biology, business.industry, Shoulder Joint, Calcinosis, medicine.disease, 3. Good health, Tendon, Resorption, 030104 developmental biology, medicine.anatomical_structure, Calcific tendonitis, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Tendinopathy, biology.protein, Fibrocartilage, Subacromial bursa, business, Calcification |
| الوصف: | International audience; Calcific tendonitis of the rotator cuff is due to apatite deposits in the shoulder tendons. Patients affected by calcific tendonitis have chronic shoulder pain and disability. Although the disease is frequent, about 10 to 42% of painful shoulders, mechanisms leading to this pathological mineralization are still largely unknown. Research reported in the 90s suggested that the formation of calcific deposits is linked to cells looking like chondrocytes identified around calcium deposits within a fibrocartilage area. They were considered to be derived from tenocytes but more recently, tendon stem cells, able to differentiate into chondrocytes, were isolated. The pro-mineralizing properties of these chondrocytes-like cells, especially the role of alkaline phosphatase, are not currently clarified. The calcium deposits contain poorly crystalline carbonated apatite associated with protein. Among these proteins, only osteopontin has been consistently identified as a potential regulating factor. During the disease, spontaneous resorption can occur with migration of apatite crystals into the subacromial bursa causing severe pain and restriction of movement. In in vivo and in vitro experiments, apatite crystals were able to induce an influx of leucocytes and a release of IL-1β and IL-18 through the activation of the NLRP3 inflammasome. However, mechanisms leading to spontaneous resolution of this inflammation and disappearance of the calcification still need to be elucidated. |
| وصف الملف: | application/pdf |
| تدمد: | 1778-7254 1297-319X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec4cffe4a5cf408848aafe53048fde7Test https://pubmed.ncbi.nlm.nih.gov/29195923Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7ec4cffe4a5cf408848aafe53048fde7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17787254 1297319X |
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