المؤلفون: Raphaël Thuillet, Alice Huertas, Etienne-Marie Jutant, Laurent Savale, Carole Phan, Christophe Guignabert, Ly Tu, Morane Le Hiress, Yuichi Tamura, Marc Humbert, Elie Fadel

المساهمون: Université Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France, AP-HP, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France., Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre chirurgical Marie Lannelongue, Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Guignabert, Christophe

المصدر: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (5), pp.1956-1970. ⟨10.1172/JCI96462⟩

مصطلحات موضوعية: 0301 basic medicine, Hypertension, Pulmonary, [SDV]Life Sciences [q-bio], Myocytes, Smooth Muscle, Lumen (anatomy), Mice, Transgenic, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Pharmacology, Pulmonary Artery, Vascular Remodeling, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Muscle, Smooth, Vascular, 03 medical and health sciences, Mice, Downregulation and upregulation, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, In vivo, medicine.artery, medicine, Cytokine Receptor gp130, Animals, Humans, Familial Primary Pulmonary Hypertension, Receptor, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS, business.industry, Interleukin-6, General Medicine, Glycoprotein 130, medicine.disease, Pulmonary hypertension, Receptors, Interleukin-6, 3. Good health, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Rats, Up-Regulation, [SDV] Life Sciences [q-bio], Arterioles, 030104 developmental biology, Pulmonary artery, Commentary, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Signal transduction, business, Research Article, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb91ea3310a8ea85ccff123a90e2b71Test
https://www.hal.inserm.fr/inserm-02580448Test

المؤلفون: Raphaël Thuillet, Timothée Quatremarre, Marc Humbert, Laurent Savale, Sven Günther, Carole Nicco, Thong Hua-Huy, Christophe Guignabert, Frédéric Batteux, Gaël Jalce, Anh Tuan Dinh-Xuan, Jennifer Bordenave, Amélie Cumont, Thomas Guilbert, Ly Tu

المساهمون: Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Sorbonne Paris Cité (USPC), Service de physiologie et explorations fonctionelles [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Sud [Le Kremlin-Bicêtre] (Faculté de Médecine), Université Paris-Saclay, Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM), APAXEN [Gosselies, Belgique], Service d'Anesthésie et de Soins Intensifs [Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, This research was supported by grants from the French National Institute for Health and Medical Research (INSERM), the University of Paris-Sud and the University Paris-Saclay, the Marie Lannelongue Hospital, the French National Agency for Research (ANR) grant No. ANR-16-CE17-0014 (TAMIRAH), the Fondation de la Recherche Médicale (FRM) grant No. DEQ20150331712 (Equipe FRM 2015), the Legs Poix (Chancellerie des Universités de Paris), and in part by the Département Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), the Assistance Publique-Hôpitaux de Paris (AP-HP), Service de Pneumologie, Centre de Référence de l’Hypertension Pulmonaire Sévère, the LabEx LERMIT (grant No ANR-10-LABX-0033), and the French PAH patient association (HTAP France). S.G. is supported by the French Fonds de Dotation 'Recherche en Santé Respiratoire' (FRSR), Fondation du Souffle (FdS). J.B. is supported by the FRM., ANR-16-CE17-0014,TAMIRAH,Cibler l'activation anormale du récepteur des minéralocorticoïdes dans l'Hypertension Artérielle Pulmonaire : Une étude translationnelle vers un traitement(2016), ANR-10-LABX-0033,LERMIT,Research Laboratory on Drugs and Therapeutic Innovation(2010), Guignabert, Christophe, Cibler l'activation anormale du récepteur des minéralocorticoïdes dans l'Hypertension Artérielle Pulmonaire : Une étude translationnelle vers un traitement - - TAMIRAH2016 - ANR-16-CE17-0014 - AAPG2016 - VALID, Research Laboratory on Drugs and Therapeutic Innovation - - LERMIT2010 - ANR-10-LABX-0033 - LABX - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2018, 19 (12), pp.4105. ⟨10.3390/ijms19124105⟩
International Journal of Molecular Sciences, 2018, 19 (12), pp.4105. ⟨10.3390/ijms19124105⟩
International Journal of Molecular Sciences, Vol 19, Iss 12, p 4105 (2018)
Volume 19
Issue 12

مصطلحات موضوعية: Male, 0301 basic medicine, [SDV]Life Sciences [q-bio], Pharmacology, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, CXCR4, molecular target, lcsh:Chemistry, Mice, chemistry.chemical_compound, Idiopathic pulmonary fibrosis, Fibrosis, Pulmonary fibrosis, Medicine, Lung, lcsh:QH301-705.5, Spectroscopy, General Medicine, respiratory system, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Computer Science Applications, Intramolecular Oxidoreductases, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Female, Receptors, CXCR4, Hypertension, Pulmonary, idiopathic pulmonary fibrosis associated with pulmonary hypertension (IPF-PH), [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Vascular Remodeling, Bleomycin, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Animals, Humans, Physical and Theoretical Chemistry, Macrophage Migration-Inhibitory Factors, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Molecular Biology, Inflammation, business.industry, Organic Chemistry, Histocompatibility Antigens Class II, Isoxazoles, medicine.disease, Pulmonary hypertension, Idiopathic Pulmonary Fibrosis, respiratory tract diseases, Antigens, Differentiation, B-Lymphocyte, Disease Models, Animal, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, chemistry, macrophage migration inhibitory factor, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Macrophage migration inhibitory factor, business, pulmonary vascular remodeling

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1520419b36104a4a126c29e52d19c5d4Test
https://doi.org/10.3390/ijms19124105Test

المؤلفون: Athénaïs Boucly, Laurent Savale, Olivier Sitbon, Marc Humbert, Marie-Camille Chaumais, Gérald Simonneau, David Montani, Xavier Jaïs, Christophe Guignabert

المساهمون: Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre chirurgical Marie Lannelongue, Hôpital Antoine Béclère, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Université Paris-Sud - Paris 11 (UP11), Centre de Référence de l’Hypertension Pulmonaire Sévère [CHU Le Kremlin Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service de Pneumologie et Réanimation Respiratoire [AP-HP Hôpital Bicêtre] (DHU TORINO), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)-Centre de Référence de l'Hypertension Pulmonaire Sévère, Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Guignabert, Christophe, Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: American Journal of Cardiovascular Drugs
American Journal of Cardiovascular Drugs, Springer Verlag, 2015, 15 (1), pp.13-26. ⟨10.1007/s40256-014-0095-y⟩

مصطلحات موضوعية: Vasculitis, medicine.medical_specialty, Pulmonary Circulation, Endothelium, medicine.drug_class, Hypertension, Pulmonary, [SDV]Life Sciences [q-bio], [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Pharmacology, Pulmonary arterial hypertension, Models, Biological, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Muscle, Smooth, Vascular, Endothelin, law.invention, Pathogenesis, Pharmacotherapy, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, law, Internal medicine, Medicine, Animals, Humans, Pharmacology (medical), Drug Interactions, Endothelial dysfunction, Antihypertensive drug, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Antihypertensive Agents, Clinical pharmacology, business.industry, Cell growth, Endothelins, General Medicine, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, [SDV] Life Sciences [q-bio], Endothelin receptor antagonists, Endocrinology, medicine.anatomical_structure, Practice Guidelines as Topic, Vascular resistance, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Drug Therapy, Combination, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, Endothelin receptor, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bea6ebbda559db7cadc3c6a8bf206bcTest
https://www.hal.inserm.fr/inserm-03224640Test