Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension
| العنوان: | Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension |
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| المؤلفون: | Athénaïs Boucly, Laurent Savale, Olivier Sitbon, Marc Humbert, Marie-Camille Chaumais, Gérald Simonneau, David Montani, Xavier Jaïs, Christophe Guignabert |
| المساهمون: | Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre chirurgical Marie Lannelongue, Hôpital Antoine Béclère, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Université Paris-Sud - Paris 11 (UP11), Centre de Référence de l’Hypertension Pulmonaire Sévère [CHU Le Kremlin Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service de Pneumologie et Réanimation Respiratoire [AP-HP Hôpital Bicêtre] (DHU TORINO), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)-Centre de Référence de l'Hypertension Pulmonaire Sévère, Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Guignabert, Christophe, Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | American Journal of Cardiovascular Drugs American Journal of Cardiovascular Drugs, Springer Verlag, 2015, 15 (1), pp.13-26. ⟨10.1007/s40256-014-0095-y⟩ |
| بيانات النشر: | HAL CCSD, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Vasculitis, medicine.medical_specialty, Pulmonary Circulation, Endothelium, medicine.drug_class, Hypertension, Pulmonary, [SDV]Life Sciences [q-bio], [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Pharmacology, Pulmonary arterial hypertension, Models, Biological, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Muscle, Smooth, Vascular, Endothelin, law.invention, Pathogenesis, Pharmacotherapy, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, law, Internal medicine, Medicine, Animals, Humans, Pharmacology (medical), Drug Interactions, Endothelial dysfunction, Antihypertensive drug, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Antihypertensive Agents, Clinical pharmacology, business.industry, Cell growth, Endothelins, General Medicine, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, [SDV] Life Sciences [q-bio], Endothelin receptor antagonists, Endocrinology, medicine.anatomical_structure, Practice Guidelines as Topic, Vascular resistance, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Drug Therapy, Combination, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, Endothelin receptor, Signal Transduction |
| الوصف: | International audience; Pulmonary arterial hypertension (PAH) is a devastating life-threatening disorder characterized by elevated pulmonary vascular resistance leading to elevated pulmonary arterial pressures, right ventricular failure and ultimately death. Vascular endothelial cells mainly produce and secrete endothelin (ET-1) in vessels that lead to a potent and long-lasting vasoconstrictive effect in pulmonary arterial smooth muscle cells. Along with its strong vasoconstrictive action, ET-1 can promote smooth muscle cell proliferation. Thus, ET-1 blockers have attracted attention as an antihypertensive drug and the ET-1 signaling system has paved a new therapeutic avenue for the treatment of PAH. The present chapter outlines not only the current understanding of the pathogenic role played by ET-1 signaling systems in the pathogenesis of PH, but also on the clinical pharmacology of endothelin receptor antagonists (ERA) used in the treatment of PAH. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1175-3277 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bea6ebbda559db7cadc3c6a8bf206bcTest https://www.hal.inserm.fr/inserm-03224640Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5bea6ebbda559db7cadc3c6a8bf206bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11753277 |
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