دورية أكاديمية
COVID-19 Outbreaks in Nursing Homes Despite Full Vaccination with BNT162b2 of a Majority of Residents
| العنوان: | COVID-19 Outbreaks in Nursing Homes Despite Full Vaccination with BNT162b2 of a Majority of Residents |
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| المؤلفون: | Lafuente, Carmelo, Rainone, Antonio, Guérin, Olivier, Drunat, Olivier, Jeandel, Claude, Hanon, Olivier, Belmin, Joël |
| المساهمون: | Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" Créteil (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Charles Foix AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Côte d'Azur (UniCA), Hôpital Bretonneau, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bretonneau, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Université de Montpellier (UM), Groupe hospitalier Broca, Sorbonne Université (SU) |
| المصدر: | ISSN: 0304-324X. |
| بيانات النشر: | HAL CCSD Karger |
| سنة النشر: | 2022 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, vaccination, outbreak, older adults, nursing home, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology |
| الوصف: | International audience ; Background: It is not known if widespread vaccination can prevent the spread of SARS-CoV-2 in subpopulations at high risk, like older adults in nursing homes (NH).Objective: To know if COVID-19 outbreaks can occur in NH with high vaccination coverage among its residents. Methods: In this case series, we identified, using national professional networks, NH that suffered COVID-19 outbreaks despite having completed a vaccination campaign, and asked them to send data, using predefined collecting forms, on the number of residents exposed, their vaccination status and the number, characteristics and evolution of patients infected. The main outcome was to identify outbreaks occurring in NH with high vaccine coverage. Secondary outcomes were residents’ risk of being infected, developing severe disease or dying from COVID-19 during the outbreak. SARS-CoV-2 infection was defined by a positive RT-PCR. All residents were serially tested whenever cases appeared in a facility. Unadjusted secondary attack rates, relative risks and vaccine effectiveness during the outbreak were estimated. Results: We identified 31 NH suffering an outbreak during March - April 2021, of which 27 sent data, cumulating 1768 residents (mean age 88.4, 73.4% women, 78.2% fully vaccinated). BNT162b2 was the vaccine employed in all NH.There were 365 cases of SARS-CoV-2 infection. Median secondary attack rates were 20.0% (IQR 4.4 – 50.0%) among unvaccinated residents and 16.7% (IQR 9.5 – 29.2%) among fully vaccinated ones. Severe cases developed in 42 of 80 (52.5%) unvaccinated patients, compared with 56 of 248 (22.6%) fully vaccinated ones (RR 4.17, 95%CI 2.43–7.17). Twenty of the unvaccinated patients (25.0%) and 16 of fully vaccinated ones (6.5%) died from COVID-19 (RR 5.11, 95%CI 2.49–10.5). Estimated vaccine effectiveness during the outbreak was 34.5% (95%CI 18.5–47.3) for preventing SARS-CoV-2 infection, 71.8% (58.8–80.7) for preventing severe disease and 83.1% (67.8–91.1) for preventing death.Conclusions: Outbreaks of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03618171; https://hal.sorbonne-universite.fr/hal-03618171Test; https://hal.sorbonne-universite.fr/hal-03618171/documentTest; https://hal.sorbonne-universite.fr/hal-03618171/file/COVID%20outbreaks%20despite%20vaccination%20Manuscript%20revised%20v2B.pdfTest |
| DOI: | 10.1159/000523701 |
| الإتاحة: | https://doi.org/10.1159/000523701Test https://hal.sorbonne-universite.fr/hal-03618171Test https://hal.sorbonne-universite.fr/hal-03618171/documentTest https://hal.sorbonne-universite.fr/hal-03618171/file/COVID%20outbreaks%20despite%20vaccination%20Manuscript%20revised%20v2B.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.F1999B12 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000523701 |
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