Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice
| العنوان: | Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice |
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| المؤلفون: | Christophe Piot, Catherine Heurteaux, Soulit Thoumala, Joël Nargeot, Christian Barrère, Laura Gallot, Anne Vincent, Michel Lazdunski, Stéphanie Barrère-Lemaire, Aurélie Covinhes |
| المساهمون: | Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique Fonctionnelle - Montpellier GenomiX (IGF MGX), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-BioCampus (BCM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Vincent, Anne |
| المصدر: | Scientific Reports Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-14822-x⟩ Scientific Reports, 2017, 7 (1), pp.14701. ⟨10.1038/s41598-017-14822-x⟩ Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, [SDV]Life Sciences [q-bio], Myocardial Infarction, lcsh:Medicine, 030204 cardiovascular system & hematology, Mice, 0302 clinical medicine, Fibrosis, Troponin I, Medicine, Chinese Traditional, lcsh:Science, Extracellular Signal-Regulated MAP Kinases, Cardioprotection, Multidisciplinary, Cerebral infarction, Heart, 3. Good health, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Oncogene Protein v-akt, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, cardioprotection, Reperfusion Injury, Cardiology, Signal Transduction, medicine.medical_specialty, traditional chinese medecine, Article, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, In vivo, Internal medicine, Heart rate, medicine, ischemia reperfusion, Animals, Humans, business.industry, Myocardium, lcsh:R, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Regional Blood Flow, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, lcsh:Q, business, Reperfusion injury, 030217 neurology & neurosurgery, Ex vivo, Drugs, Chinese Herbal |
| الوصف: | MLC901, a traditional Chinese medicine containing a cocktail of active molecules, both reduces cerebral infarction and improves recovery in patients with ischemic stroke. The aim of this study was to evaluate the acute and long-term benefits of MLC901 in ischemic and reperfused mouse hearts. Ex vivo, under physiological conditions, MLC901 did not show any modification in heart rate and contraction amplitude. However, upon an ischemic insult, MLC901 administration during reperfusion, improved coronary flow in perfused hearts. In vivo, MLC901 (4 µg/kg) intravenous injection 5 minutes before reperfusion provided a decrease in both infarct size (49.8%) and apoptosis (49.9%) after 1 hour of reperfusion. Akt and ERK1/2 survival pathways were significantly activated in the myocardium of those mice. In the 4-month clinical follow-up upon an additional continuous per os administration, MLC901 treatment decreased cardiac injury as revealed by a 45%-decrease in cTnI plasmatic concentrations and an improved cardiac performance assessed by echocardiography. A histological analysis revealed a 64%-decreased residual scar fibrosis and a 44%-increased vascular density in the infarct region. This paper demonstrates that MLC901 treatment was able to provide acute and long-term cardioprotective effects in a murine model of myocardial ischemia-reperfusion injury in vivo. |
| وصف الملف: | application/pdf |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6323b2f69ddd382e1845cc549d971e86Test https://pubmed.ncbi.nlm.nih.gov/29089640Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6323b2f69ddd382e1845cc549d971e86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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