المؤلفون: Couderc, Elodie, Morel, Franck, Levillain, Pierre, Buffière-Morgado, Amandine, Camus, Magalie, Paquier, Camille, Bodet, Charles, Jégou, Jean-François, Pohin, Mathilde, Favot, Laure, Garcia, Martine, Huguier, Vincent, Mcheik, Jiad, Lacombe, Corinne, Yssel, Hans, Guillet, Gérard, Bernard, François-Xavier, Lecron, Jean-Claude

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines EA 4331 (LITEC Poitiers ), Université de Poitiers = University of Poitiers (UP), Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1932-6203.

مصطلحات موضوعية: Protein-coupled receptor, skin inflammation, kappa-b, rheumatoid-arthritis, oncostatin-m, expression, binding, cd36, differentiation, secretion, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

الوصف: International audience ; Background; Acute-serum Amyloid A (A-SAA), one of the major acute-phase proteins, is mainly produced in the liver but extra-hepatic synthesis involving the skin has been reported. Its expression is regulated by the transcription factors NF-κB, C/EBPβ, STAT3 activated by proinflammatory cytokines.Objectives: We investigated A-SAA synthesis by resting and cytokine-activated Normal Human Epidermal Keratinocytes (NHEK), and their inflammatory response to A-SAA stimulation. A-SAA expression was also studied in mouse skin and liver in a model mimicking psoriasis and in the skin and sera of psoriatic and atopic dermatitis (AD) patients.Methods: NHEK were stimulated by A-SAA or the cytokines IL-1α, IL-17A, IL-22, OSM, TNF-α alone or in combination, previously reported to reproduce features of psoriasis. Murine skins were treated by imiquimod cream. Human skins and sera were obtained from patients with psoriasis and AD. A-SAA mRNA was quantified by RT qPCR. A-SAA proteins were dosed by ELISA or immunonephelemetry assay.Results: IL-1α, TNF-α and mainly IL-17A induced A-SAA expression by NHEK. A-SAA induced its own production and the synthesis of hBD2 and CCL20, both ligands for CCR6, a chemokine receptor involved in the trafficking of Th17 lymphocytes. A-SAA expression was increased in skins and livers from imiquimod-treated mice and in patient skins with psoriasis, but not significantly in those with AD. Correlations between A-SAA and psoriasis severity and duration were observed.Conclusion: Keratinocytes could contribute to psoriasis pathogenesis via A-SAA production, maintaining a cutaneous inflammatory environment, activating innate immunity and Th17 lymphocyte recruitment.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28708859; hal-01703911; https://hal.science/hal-01703911Test; https://hal.science/hal-01703911/documentTest; https://hal.science/hal-01703911/file/4f8f6650df3a813ef887c285ddc21378.pdfTest; PUBMED: 28708859; PUBMEDCENTRAL: PMC5510841

الإتاحة: https://doi.org/10.1371/journal.pone.0181486Test
https://hal.science/hal-01703911Test
https://hal.science/hal-01703911/documentTest
https://hal.science/hal-01703911/file/4f8f6650df3a813ef887c285ddc21378.pdfTest

المؤلفون: Couderc, Elodie, Morel, Franck, Levillain, Pierre, Buffière-Morgado, Amandine, Camus, Magalie, Paquier, Camille, Bodet, Charles, Jégou, Jean-François, Pohin, Mathilde, Favot, Laure, Garcia, Martine, Huguier, Vincent, Mcheik, Jiad, Lacombe, Corinne, Yssel, Hans, Guillet, Gérard, Bernard, François-Xavier, Lecron, Jean-Claude

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines EA 4331 (LITEC Poitiers ), Université de Poitiers = University of Poitiers (UP), Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1932-6203.

مصطلحات موضوعية: Protein-coupled receptor, skin inflammation, kappa-b, rheumatoid-arthritis, oncostatin-m, expression, binding, cd36, differentiation, secretion, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

الوصف: International audience ; Background; Acute-serum Amyloid A (A-SAA), one of the major acute-phase proteins, is mainly produced in the liver but extra-hepatic synthesis involving the skin has been reported. Its expression is regulated by the transcription factors NF-κB, C/EBPβ, STAT3 activated by proinflammatory cytokines.Objectives: We investigated A-SAA synthesis by resting and cytokine-activated Normal Human Epidermal Keratinocytes (NHEK), and their inflammatory response to A-SAA stimulation. A-SAA expression was also studied in mouse skin and liver in a model mimicking psoriasis and in the skin and sera of psoriatic and atopic dermatitis (AD) patients.Methods: NHEK were stimulated by A-SAA or the cytokines IL-1α, IL-17A, IL-22, OSM, TNF-α alone or in combination, previously reported to reproduce features of psoriasis. Murine skins were treated by imiquimod cream. Human skins and sera were obtained from patients with psoriasis and AD. A-SAA mRNA was quantified by RT qPCR. A-SAA proteins were dosed by ELISA or immunonephelemetry assay.Results: IL-1α, TNF-α and mainly IL-17A induced A-SAA expression by NHEK. A-SAA induced its own production and the synthesis of hBD2 and CCL20, both ligands for CCR6, a chemokine receptor involved in the trafficking of Th17 lymphocytes. A-SAA expression was increased in skins and livers from imiquimod-treated mice and in patient skins with psoriasis, but not significantly in those with AD. Correlations between A-SAA and psoriasis severity and duration were observed.Conclusion: Keratinocytes could contribute to psoriasis pathogenesis via A-SAA production, maintaining a cutaneous inflammatory environment, activating innate immunity and Th17 lymphocyte recruitment.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28708859; hal-01703911; https://hal.science/hal-01703911Test; https://hal.science/hal-01703911/documentTest; https://hal.science/hal-01703911/file/4f8f6650df3a813ef887c285ddc21378.pdfTest; PUBMED: 28708859; PUBMEDCENTRAL: PMC5510841

الإتاحة: https://doi.org/10.1371/journal.pone.0181486Test
https://hal.science/hal-01703911Test
https://hal.science/hal-01703911/documentTest
https://hal.science/hal-01703911/file/4f8f6650df3a813ef887c285ddc21378.pdfTest

المؤلفون: Couderc, Elodie, Morel, Franck, Levillain, Pierre, Buffière-Morgado, Amandine, Camus, Magalie, Paquier, Camille, Bodet, Charles, Jégou, Jean-François, Pohin, Mathilde, Favot, Laure, Garcia, Martine, Huguier, Vincent, Mcheik, Jiad, Lacombe, Corinne, Yssel, Hans, Guillet, Gérard, Bernard, François-Xavier, Lecron, Jean-Claude

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines (LITEC), Université de Poitiers, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), BIOalternatives (BIOalternatives SAS), entreprise privé

المصدر: ISSN: 1932-6203.

مصطلحات موضوعية: [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]

الوصف: International audience

العلاقة: hal-01703911; https://hal.archives-ouvertes.fr/hal-01703911Test

الإتاحة: https://doi.org/10.1371/journal.pone.0181486Test
https://hal.archives-ouvertes.fr/hal-01703911Test

المؤلفون: Giot, Jean-Philippe, Petit-Paris, Isabelle, Levillain, Pierre, Huguier, Vincent, Charreau, Sandrine, Delwail, Adriana, Garcia, Martine, Garnier, Julien, Bernard, François-Xavier, Dagregorio, Guy, Guillet, Gérard, Morel, Franck, Lecron, Jean-Claude, Favot, Laure

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines EA 4331 (LITEC Poitiers ), Université de Poitiers = University of Poitiers (UP), Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), QIMA Bioalternatives (QIMA Life Sciences)

المصدر: ISSN: 0002-9440.

مصطلحات موضوعية: [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

الوصف: International audience

العلاقة: hal-01703039; https://univ-poitiers.hal.science/hal-01703039Test

الإتاحة: https://doi.org/10.1016/j.ajpath.2012.11.030Test
https://univ-poitiers.hal.science/hal-01703039Test

المؤلفون: Giot, Jean-Philippe, Pâris, Isabelle, Levillain, Pierre, Huguier, Vincent, Charreau, Sandrine, Delwail, Adrianna, Garcia, Martine, Garnier, Julien, Bernard, François-Xavier, Dagregorio, Guy, Guillet, Gérard, Morel, Franck, Lecron, Jean-Claude, Favot, Laure

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines (LITEC), Université de Poitiers, Centre hospitalier universitaire de Poitiers (CHU Poitiers), BIOalternatives (BIOalternatives SAS), entreprise privé

المصدر: ISSN: 0002-9440.

مصطلحات موضوعية: [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]

الوصف: International audience

العلاقة: hal-01703039; https://univ-poitiers.hal.science/hal-01703039Test

الإتاحة: https://doi.org/10.1016/j.ajpath.2012.11.030Test
https://univ-poitiers.hal.science/hal-01703039Test

المؤلفون: Giot, Jean-Philippe, Pâris, Isabelle, Levillain, Pierre, Huguier, Vincent, Charreau, Sandrine, Delwail, Adrianna, Garcia, Martine, Garnier, Julien, Bernard, François-Xavier, Dagregorio, Guy, Guillet, Gérard, Morel, Franck, Lecron, Jean-Claude, Favot, Laure

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines (LITEC), Université de Poitiers, Centre hospitalier universitaire de Poitiers (CHU Poitiers), BIOalternatives (BIOalternatives SAS), entreprise privé

المصدر: ISSN: 0002-9440.

مصطلحات موضوعية: [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]

الوصف: International audience

العلاقة: hal-01703039; https://hal-univ-poitiers.archives-ouvertes.fr/hal-01703039Test

الإتاحة: https://doi.org/10.1016/j.ajpath.2012.11.030Test
https://hal-univ-poitiers.archives-ouvertes.fr/hal-01703039Test

المؤلفون: Boniface, Katia, Guignouard, Emmanuel, Pedretti, Nathalie, Garcia, Martine, Bernard, F.X., Nau, François, Guillet, Gérard, Dagregorio, Guy, Yssel, Hans, Lecron, Jean-Claude, Morel, Franck

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines EA 4331 (LITEC Poitiers ), Université de Poitiers = University of Poitiers (UP), QIMA Bioalternatives (QIMA Life Sciences), Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Laboratoire Cytokines et Inflammation ( Poitiers )

المصدر: ISSN: 0009-9104.

مصطلحات موضوعية: [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

الوصف: International audience

العلاقة: hal-01705160; https://univ-poitiers.hal.science/hal-01705160Test

الإتاحة: https://doi.org/10.1111/j.1365-2249.2007.03511.xTest
https://univ-poitiers.hal.science/hal-01705160Test

المؤلفون: Boniface, Katia, Diveu, Caroline, Morel, Franck, Pedretti, Nathalie, Froger, Josy, Ravon, Elisa, Garcia, Martine, Venereau, Emilie, Preisser, Laurence, Guignouard, Emmanuel, Guillet, Gérard, Dagregorio, Guy, Pene, Jérôme, Moles, Jean-Pierre, Yssel, Hans, Chevalier, Sylvien, Bernard, François-Xavier, Gascan, Hugues, Lecron, Jean-Claude

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines EA 4331 (LITEC Poitiers ), Université de Poitiers = University of Poitiers (UP), Cytokines : structure, signalisation et prolifération tumorale, Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), QIMA Bioalternatives (QIMA Life Sciences), Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Immunopathologie de l'Inflammation, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Cytokines et Inflammation ( Poitiers )

المصدر: ISSN: 0022-1767.

مصطلحات موضوعية: [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

الوصف: International audience

العلاقة: hal-01705182; https://univ-poitiers.hal.science/hal-01705182Test

الإتاحة: https://doi.org/10.4049/jimmunol.178.7.4615Test
https://univ-poitiers.hal.science/hal-01705182Test

المؤلفون: Boniface, Katia, Diveu, Caroline, Morel, Franck, Pedretti, Nathalie, Froger, Josy, Ravon, Elisa, Garcia, Martine, Venereau, Emilie, Preisser, Laurence, Guignouard, Emmanuel, Guillet, Gérard, Dagregorio, Guy, Pene, Jérôme, Moles, Jean-Pierre, Yssel, Hans, Chevalier, Sylvien, Bernard, François-Xavier, Gascan, Hugues, Lecron, Jean-Claude

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines EA 4331 (LITEC Poitiers ), Université de Poitiers = University of Poitiers (UP), Cytokines : structure, signalisation et prolifération tumorale, Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), QIMA Bioalternatives (QIMA Life Sciences), Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Immunopathologie de l'Inflammation, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Cytokines et Inflammation ( Poitiers )

المصدر: ISSN: 0022-1767.

مصطلحات موضوعية: [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

الوصف: International audience

العلاقة: hal-01705182; https://univ-poitiers.hal.science/hal-01705182Test

الإتاحة: https://doi.org/10.4049/jimmunol.178.7.4615Test
https://univ-poitiers.hal.science/hal-01705182Test

المؤلفون: Boniface, Katia, Diveu, Caroline, Morel, Franck, Pedretti, Nathalie, Froger, Josy, Ravon, Elisa, Garcia, Martine, Venereau, Emilie, Preisser, Laurence, Guignouard, Emmanuel, Guillet, Gérard, Dagregorio, Guy, Pene, Jérôme, Moles, Jean-Pierre, Yssel, Hans, Chevalier, Sylvien, Bernard, François-Xavier, Gascan, Hugues, Lecron, Jean-Claude

المساهمون: Laboratoire Inflammation, Tissus épithéliaux et Cytokines EA 4331 (LITEC Poitiers ), Université de Poitiers = University of Poitiers (UP), Cytokines : structure, signalisation et prolifération tumorale, Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), QIMA Bioalternatives (QIMA Life Sciences), Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Immunopathologie de l'Inflammation, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Cytokines et Inflammation ( Poitiers )

المصدر: ISSN: 0022-1767.

مصطلحات موضوعية: [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

الوصف: International audience

العلاقة: hal-01705182; https://univ-poitiers.hal.science/hal-01705182Test

الإتاحة: https://doi.org/10.4049/jimmunol.178.7.4615Test
https://univ-poitiers.hal.science/hal-01705182Test