دورية أكاديمية
Characteristics, management and outcomes of active cancer patients with cardiogenic shock
| العنوان: | Characteristics, management and outcomes of active cancer patients with cardiogenic shock |
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| المؤلفون: | Merdji, Hamid, Gantzer, Justine, Bonello, Laurent, Lamblin, Nicolas, Roubille, François, Levy, Bruno, Champion, Sebastien, Lim, Pascal, Schneider, Francis, Cariou, Alain, Khachab, Hadi, Bourenne, Jeremy, Seronde, Marie-France, Schurtz, Guillaume, Harbaoui, Brahim, Vanzetto, Gerald, Quentin, Charlotte, Curtiaud, Anais, Kurtz, Jean-Emmanuel, Combaret, Nicolas, Marchandot, Benjamin, Lattuca, Benoit, Biendel, Caroline, Leurent, Guillaume, Bataille, Vincent, Gerbaud, Edouard, Puymirat, Etienne, Bonnefoy, Eric, Aissaoui, Nadia, Delmas, Clément |
| المساهمون: | Université de Strasbourg (UNISTRA), Institut de Cancérologie de Strasbourg Europe (ICANS), Assistance Publique - Hôpitaux de Marseille (APHM), Mediterranean Association for Research and Studies in Cardiology (MARS cardio), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Centre de recherche Cardio-Thoracique de Bordeaux Bordeaux (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) |
| المصدر: | ISSN: 2048-8726 ; EISSN: 2048-8734. |
| بيانات النشر: | HAL CCSD SAGE Publications |
| سنة النشر: | 2023 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | cancer, cardio-oncology, cardiogenic shock, heart failure, prognosis, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; Aims: Characteristics, management, and outcomes of patients with active cancer admitted for cardiogenic shock remain largely unknown. This study aimed to address this issue and identify the determinants of 30-day and 1-year mortality in a large cardiogenic shock cohort of all etiologies.Methods and results: FRENSHOCK is a prospective multicenter observational registry conducted in French critical care units between April and October 2016. "Active cancer" was defined as a malignancy diagnosed within the previous weeks with planned or ongoing anticancer therapy. Among the 772 enrolled patients (mean age 65.7 ± 14.9 years; 71.5% male), 51 (6.6%) had active cancer. Among them, the main cancer types were solid cancers (60.8%), and hematological malignancies (27.5%). Solid cancers were mainly urogenital (21.6%), gastrointestinal (15.7%), and lung cancer (9.8%). Medical history, clinical presentation, and baseline echocardiography were almost the same between groups. In-hospital management significantly differed: patients with cancers received more catecholamines or inotropes (norepinephrine 72 vs 52%, p=0.005 and norepinephrine-dobutamine combination 64.7 vs 44.5%, p=0.005), but had less mechanical circulatory support (5.9 vs 19.5%, p=0.016). They presented similar 30-day mortality rate (29 vs 26%) but a significantly higher mortality at one-year (70.6 vs 45.2%, p<0.001). In multivariable analysis, active cancer was not associated with 30-day mortality but was significantly associated with 1-year mortality in 30-day survivors (HR 3.61 [1.29 - 10.11], p=0.015).Conclusion: Active cancer patients accounted for almost 7% of all cases of cardiogenic shock. Early mortality was the same regardless active cancer or not, whereas long-term mortality was significantly increased in patients with active cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37410588; hal-04154866; https://hal.science/hal-04154866Test; https://hal.science/hal-04154866/documentTest; https://hal.science/hal-04154866/file/Merdji%20et%20al-2023-Characteristics,%20management%20and%20outcomes%20of%20active%20cancer%20patients%20with%20cardiogenic.pdfTest; PUBMED: 37410588 |
| DOI: | 10.1093/ehjacc/zuad072 |
| الإتاحة: | https://doi.org/10.1093/ehjacc/zuad072Test https://hal.science/hal-04154866Test https://hal.science/hal-04154866/documentTest https://hal.science/hal-04154866/file/Merdji%20et%20al-2023-Characteristics,%20management%20and%20outcomes%20of%20active%20cancer%20patients%20with%20cardiogenic.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.BB781E99 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjacc/zuad072 |
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