دورية أكاديمية
Danio rerio ABC transporter genes abcb3 and abcb7 play a protecting role against metal contamination
| العنوان: | Danio rerio ABC transporter genes abcb3 and abcb7 play a protecting role against metal contamination |
|---|---|
| المؤلفون: | Lerebours, Adelaide, To, van Vinh, Bourdineaud, Jean-Paul |
| المساهمون: | University of Hull United Kingdom, Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0260-437X. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2016 |
| المجموعة: | Institut national des sciences de l'Univers: HAL-INSU |
| مصطلحات موضوعية: | ABC transporters, zebrafish, protection, metals, mitochondrial transporter, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology |
| الوصف: | International audience ; ATP‐binding cassette (ABC) proteins are efflux transporters and some of them are involved in xenobiotic detoxification. The involvement of four zebrafish ABC transporters in cadmium, zinc and mercury detoxification was characterized in a metal hypersensitive mutant of Escherichia coli. The E. coli tolC mutant expressing ABCB3 or ABCB7 transporters exhibited higher survival ratios and lower metal accumulation under a metal exposure condition than the controls. For instance, in the presence of 8 and 10 μM of HgCl2, the survival ratios of bacteria expressing ABCB3 were four and six‐times higher than the control whereas the mercury concentrations were 2.5 and 2‐times lower than in the control. This work provides new data on the function of zebrafish ABCB3 and ABCB7 transporters and highlights their significance in metal detoxification |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-02155114; https://hal.science/hal-02155114Test; https://hal.science/hal-02155114/documentTest; https://hal.science/hal-02155114/file/Manuscript%20Accepted%20JAT%202016.pdfTest |
| DOI: | 10.1002/jat.3313 |
| الإتاحة: | https://doi.org/10.1002/jat.3313Test https://hal.science/hal-02155114Test https://hal.science/hal-02155114/documentTest https://hal.science/hal-02155114/file/Manuscript%20Accepted%20JAT%202016.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.DC897656 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jat.3313 |
|---|