دورية أكاديمية
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management.
| العنوان: | A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. |
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| المؤلفون: | Pi-Sunyer, Xavier, Astrup, Arne, Fujioka, Ken, Greenway, Frank, Halpern, Alfredo, Krempf, Michel, Lau, David C W, Le Roux, Carel W, Violante Ortiz, Rafael, Jensen, Christine Bjørn, Wilding, John P H, Scale Obesity And Prediabetes Nn8022-1839 Study Group, . |
| المساهمون: | Columbia University New York, Obesity Research Center, The University of Tennessee Knoxville, Department of Nutrition, Exercise and Sports Copenhagen, Faculty of Science Copenhagen, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), The Scripps Research Institute La Jolla, San Diego, Louisiana State University (LSU), Universidade de São Paulo = University of São Paulo (USP), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), University of Calgary, University College Dublin (UCD), Instituto Mexicano del Seguro Social Mexico City, Mexico (IMSS), Novo Nordisk, Department of Obesity and Endocrinology, University of Liverpool |
| المصدر: | ISSN: 0028-4793. |
| بيانات النشر: | HAL CCSD Massachusetts Medical Society |
| سنة النشر: | 2015 |
| المجموعة: | Institut National de la Recherche Agronomique: ProdINRA |
| مصطلحات موضوعية: | type 2 diabetes, Obesity, Liraglutide, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Background Obesity is a chronic disease with serious health consequences, but weight loss is difficult to maintain through lifestyle intervention alone. Liraglutide, a glucagon-like peptide-1 analogue, has been shown to have potential benefit for weight management at a once-daily dose of 3.0 mg, injected subcutaneously. Methods We conducted a 56-week, double-blind trial involving 3731 patients who did not have type 2 diabetes and who had a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of at least 30 or a BMI of at least 27 if they had treated or untreated dyslipidemia or hypertension. We randomly assigned patients in a 2:1 ratio to receive once-daily subcutaneous injections of liraglutide at a dose of 3.0 mg (2487 patients) or placebo (1244 patients); both groups received counseling on lifestyle modification. The coprimary end points were the change in body weight and the proportions of patients losing at least 5% and more than 10% of their initial body weight. Results At baseline, the mean (±SD) age of the patients was 45.1±12.0 years, the mean weight was 106.2±21.4 kg, and the mean BMI was 38.3±6.4; a total of 78.5% of the patients were women and 61.2% had prediabetes. At week 56, patients in the liraglutide group had lost a mean of 8.4±7.3 kg of body weight, and those in the placebo group had lost a mean of 2.8±6.5 kg (a difference of −5.6 kg; 95% confidence interval, −6.0 to −5.1; P<0.001, with last-observation-carried-forward imputation). A total of 63.2% of the patients in the liraglutide group as compared with 27.1% in the placebo group lost at least 5% of their body weight (P<0.001), and 33.1% and 10.6%, respectively, lost more than 10% of their body weight (P<0.001). The most frequently reported adverse events with liraglutide were mild or moderate nausea and diarrhea. Serious events occurred in 6.2% of the patients in the liraglutide group and in 5.0% of the patients in the placebo group. Conclusions In this study, 3.0 mg ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26132939; hal-02640513; https://hal.inrae.fr/hal-02640513Test; PRODINRA: 426852; PUBMED: 26132939; WOS: 000357218700004 |
| DOI: | 10.1056/NEJMoa1411892 |
| الإتاحة: | https://doi.org/10.1056/NEJMoa1411892Test https://hal.inrae.fr/hal-02640513Test |
| رقم الانضمام: | edsbas.65C034F9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1056/NEJMoa1411892 |
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