المؤلفون: Perez-De-Llano, Luis, Scelo, Ghislaine, Canonica, G. Walter, Chen, Wenjia, Henley, William, Larenas-Linnemann, Désirée, Peters, Matthesadatw, Pfeffer, Paul, Tran, Trung, Ulrik, Charlotte Suppli, Popov, Todor, Sadatsafavi, Mohsen, Hew, Mark, Maspero, Jorge, Gibson, Peter, Christoff, George, Fitzgerald, J. Mark, Torres-Duque, Carlos, Porsbjerg, Celeste, Papadopoulos, Nikolaos, Papaioannou, Andriana, Heffler, Enrico, Iwanaga, Takashi, Al-Ahmad, Mona, Kuna, Piotr, Fonseca, João, Al-Lehebi, Riyad, Rhee, Chin Kook, Koh, Mariko Siyue, Cosio, Borja, Mahboub, Bassam, Menzies-Gow, Andrew, Jackson, David, Busby, John, Heaney, Liam, Patel, Pujan, Wang, Eileen, Wechsler, Michael, Altraja, Alan, Lehtimäki, Lauri, Bourdin, Arnaud, Bjermer, Leif, Bulathsinhala, Lakmini, Carter, Victoria, Murray, Ruth, Beastall, Aaron, Denton, Eve, Price, David

المساهمون: Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)

المصدر: ISSN: 1081-1206.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience

العلاقة: hal-04365478; https://hal.science/hal-04365478Test; https://hal.science/hal-04365478/documentTest; https://hal.science/hal-04365478/file/2023%20%20%20Perez-de-Llano%20%20%20et%20al.,%20Impact%20of%20pr1.pdfTest

الإتاحة: https://doi.org/10.1016/j.anai.2023.12.023Test
https://hal.science/hal-04365478Test
https://hal.science/hal-04365478/documentTest
https://hal.science/hal-04365478/file/2023%20%20%20Perez-de-Llano%20%20%20et%20al.,%20Impact%20of%20pr1.pdfTest

المؤلفون: Chen, Wenjia, Tran, Trung, Sadatsafavi, Mohsen, Murray, Ruth, Boon Wong, Nigel Chong, Ali, Nasloon, Ariti, Con, Bulathsinhala, Lakmini, Garcia Gil, Esther, Fitzgerald, J. Mark, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne-Sofie, Bourdin, Arnaud, von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George, Cosio, Borja, Costello, Richard, Fonseca, João, Gibson, Peter, Yoo, Kwang Ha, Heaney, Liam, Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David, Jones, Rupert, Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri, Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew, Newell, Anthony, Sirena, Concetta, Papadopoulos, Nikolaos, Papaioannou, Andriana, Perez-De-Llano, Luis, Peters, Matthew, Pfeffer, Paul, Porsbjerg, Celeste, Popov, Todor, Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos, Ulrik, Charlotte, Ra, Seung Won, Wang, Eileen, Wechsler, Michael, Price, David

المساهمون: Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)

المصدر: ISSN: 2213-2198 ; EISSN: 2213-2201.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience

العلاقة: hal-04450320; https://hal.science/hal-04450320Test; https://hal.science/hal-04450320/documentTest; https://hal.science/hal-04450320/file/2024%20%20Chen%20%20%20et%20al.,%20Reply%20to.pdfTest

الإتاحة: https://doi.org/10.1016/j.jaip.2023.12.008Test
https://hal.science/hal-04450320Test
https://hal.science/hal-04450320/documentTest
https://hal.science/hal-04450320/file/2024%20%20Chen%20%20%20et%20al.,%20Reply%20to.pdfTest

المؤلفون: Sousa-Pinto, Bernardo, Louis, Renaud E., Anto, Josep María, Amaral, R., Sá-Sousa, Ana, Czarlewski, Wienczyslawa, Brussino, Luisa, Canonica, Walter G., Chaves Loureiro, Cláudia, Cruz, Álvaro Augusto, Gemicioglu, Bilun, Haahtela, Tari M.K., Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Désirée E.S., Okamoto, Y., Ollert, Markus W., Pfaar, Oliver, Pham-Thi, Nhân, Puggioni, Francesca A., Regateiro, Frederico Soares, Romantowski, Jan, Sastre, Joaquín, Scichilone, Nicola, Taborda-Barata, Luís Manuel, Ventura, M. T., Agache, Ioana O., Bedbrook, Anna, Becker, Sven, Bergmann, Karl Christian, Bosnic-Anticevich, Sinthia Zrinka, Bonini, Matteo, Boulet, Louis Philippe, Brusselle, Guy G.O., Buhl, Roland Otto, Cecchi, Lorenzo, Charpin, Denis André, de Blay, Frédéric J., del Giacco, Stefano R., Ivancevich, J. C., Jutel, Marek, Klimek, Ludger, Kraxner, Helga, Kuna, P. B., Laune, Daniel, Makela, Mika Juhani, Morais-Almeida, Riccardo A., Nadif, Rachel, Niedoszytko, Marek B., Papadopoulos, N. G., Papi, Alberto A., Patella, Vincenzo, Pétré, Benoît, Rivero Yeverino, Daniela, Robalo Cordeiro, Carlos, Roche, Nicolas, Rouadi, Philip W., Samolinski, Bolesław Krzysztof, Savouré, Marine, Shamji, Mohamed H., Sheikh, Aziz, Suppli Ulrik, Charlotte Suppli, Usmani, Omar Sharif, Valiulis, Arūnas, Yorgancioglu, Arzu A., Zuberbier, Thorsten, Fonseca, João Almeida, Costa, Elisio M., Bousquet, Jean J.

المساهمون: Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, American Heart Association, AHA, (H2020), EIT Health, HORIZON EUROPE Framework Programme, European Commission, EC

المصدر: ISSN: 2531-0429 ; Pulmonology ; https://hal.science/hal-04195104Test ; Pulmonology, 2023, ⟨10.1016/j.pulmoe.2023.07.004⟩.

مصطلحات موضوعية: Adherence, Asthma, Formoterol, Inhaled corticosteroids, Long-acting-β2 agonist, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA. Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day. Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001). Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37543524; hal-04195104; https://hal.science/hal-04195104Test; https://hal.science/hal-04195104/documentTest; https://hal.science/hal-04195104/file/1-s2.0-S2531043723001307-main.pdfTest; PUBMED: 37543524

الإتاحة: https://doi.org/10.1016/j.pulmoe.2023.07.004Test
https://hal.science/hal-04195104Test
https://hal.science/hal-04195104/documentTest
https://hal.science/hal-04195104/file/1-s2.0-S2531043723001307-main.pdfTest

المؤلفون: Bousquet, Jean J., Melén, Erik, Haahtela, Tari M.K., Koppelman, Gerard H., Togias, Alkis G., Valenta, Rudolf, Akdis, Cezmi Ali, Czarlewski, Wienczyslawa, Rothenberg, Marc E., Valiulis, Arūnas, Wickman, Magnus C., Akdis, Mübeccel, Aguilar, Daniel, Bedbrook, Anna, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia Zrinka, Boulet, Louis Philippe, Brightling, Christopher Edward, Brussino, Luisa, Burte, Emilie, Bustamante, Mariona, Canonica, Walter G., Cecchi, Lorenzo, Celedon, Juan Carlos, Chaves Loureiro, Cláudia, Costa, Elísio Sbardellotto Mariano Da, Cruz, Álvaro Augusto, Erhola, Marina L., Gemicioglu, Bilun, Fokkens, Wytske Johanna, Garcia-Aymerich, Judith M., Guerra, Stefano, Heinrich, Joachim, Ivancevich, J. C., Keil, Thomas, Klimek, Ludger, Kuna, P. B., Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Désirée E.S., Lemonnier, Nathanaël, Lodrup Carlsen, Karin Cecilie, Louis, Renaud E., Makela, Mika Juhani, Makris, Michael P., Maurer, Marcus, Momas, Isabelle, Morais-Almeida, Mário, Mullol, Joaquim, Naclerio, Robert M., Nadeau, Kari Christine, Nadif, Rachel, Niedoszytko, Marek B., Okamoto, Yoshitaka, Ollert, Markus W., Papadopoulos, Nikolaos G., Passalacqua, Giovanni G., Patella, Vincenzo, Pawankar, Ruby U., Pham-Thi, Nhân, Pfaar, Oliver, Regateiro, Frederico Soares, Ring, Johannes, Rouadi, Philip W., Samolinski, Bolesław Krzysztof, Sastre, Joaquín, Savouré, Marine, Scichilone, Nicola, Shamji, Mohamed H., Sheikh, Aziz, Siroux, Valérie, Sousa-Pinto, Bernardo, Standl, Marie, Sunyer, Jordi A., Taborda-Barata, Luís Manuel, Toppila-Salmi, Sanna Katriina, Torres, María José, Tsiligianni, Ioanna G., Valovirta, Erkka Juhani, Vandenplas, Olivier, Ventura, M. T., Weiss, Scott T., Yorgancioglu, Arzu A., Zhang, Luo, Abdul Latiff, Amir Hamzah, Aberer, Werner, Agache, Ioana O., Al-Ahmad, Mona S., Alobid, Isam, Ansotegui, Ignacio Javier, Arshad, Syed Hasan, Asayag, Estrella, Barbara, Cristina, Baharudin, Abdullah, Battur, Lkhagvaa, Bennoor, Kazi Saifuddin, Berghea, Elena Camelia, Bergmann, Karl Christian, Bernstein, David Isaac, Bewick, Michael, Blain, Hubert, Bonini, Matteo, Braido, Fulvio, Buhl, Roland Otto, Bumbacea, Roxana Silvia, Bush, Andrew P., Calderon, Moiśes A., Calvo-Gil, Mario A., Camargos, Paulo Augusto Moreira, Caraballo, Luis R., Cardona, Victoria, Carr, Warner W., Carreiro-Martins, Pedro, Casale, T. Bruce, Cepeda Sarabia, Alfonso Mario, Chandrasekharan, Ramanathan, Charpin, Denis André, Chen, Yuzhi, Cherrez-Ojeda, Ivan, Chivato, Tomas, Chkhartishvili, Ekaterine S., Christoff, George, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Corrigan, C. J., Custovic, Adnan, D’amato, Gennaro, del Giacco, Stefano Renato, de Blay, Frédéric J., Devillier, Philippe, Didier, Alain P., Do Ceu Teixeira, Maria, Dokic, Dejand, Douagui, Habib B., Doulaptsi, Maria V., Durham, Stephen R., Dykewicz, Mark S., Eiwegger, Thomas, El-Sayed, Zeinab Awad, Emuzyte, Regina, Fiocchi, Alessandro Giovanni, Fyhrquist, Nanna, Gomez, René Maximiliano, Gotua, Maia A., Guzman, María Antonieta, Hagemann, Jan Hendrik, Hamamah, Samir, Halken, Susanne, Halpin, David M.G., Hofmann, Maja Ann, Hossny, Elham M., Hrubiško, Martin, Irani, Carla, Ispayeva, Zhanat B., Jares, Edgardo José, Jartti, Tuomas T., Jassem, Ewa, Julge, Kaja, Just, Jocelyne, Jutel, Marek, Kaidashev, I. P., Kalayci, Ömer, Kalyoncu, Ali Fuat, Kardas, Przemysław, Kirenga, Bruce James, Kraxner, Helga, Kull, Inger, Kulus, Marek, La Grutta, Stefania, Lau, Susanne, Le Tuyet Thi, L., Levin, Michael E., Lipworth, Brian Jonathon, Lourenço, Olga, Mahboub, Bassam H., Martinez-Infante, Eric A., Matricardi, Paolo Maria, Miculinic, Neven, Migueres, Nicolas, Mihaltan, Florin Dumitru, Mohammad, Yousser, Moniuszko, Marcin, Montefort, Stephen R., Neffen, Hugo E., Nekam, Kristoff, Nunes, Elizabete Abrantes, Nyembue Tshipukane, Dieudonné, O’hehir, Robyn E., Ogulur, İsmail, Ohta, Ken, Okubo, Kimihiro, Ouedraogo, Solange Odile Yugbaré, Olze, Heidi, Pali-Schöll, Isabella Maria, Palomares, Óscar, Palosuo, Kati, Panaitescu, Carmen Bunu, Panzner, Petr, Park, Haesim, Pitsios, Constantinos, Plavec, Davor, Popov, T. A., Puggioni, Francesca A., Quirce, Santiago, Recto, Marysia Tiongco, Repka-Ramirez, María Susana, Robalo Cordeiro, Carlos, Roche, Nicolas, Rodriguez-Gonzalez, Mónica, Romantowski, Jan, Rosario Filho, Nelson Augusto, Rottem, Menachem, Sagara, Hironori, Serpa, Faradiba Sarquis, Sayah, Z., Scheire, Sophie, Schmid-Grendelmeier, Peter D., Sisul, Juan Carlos, Sole, Dirceu, Soto-Martinez, Manuel E., Sova, Milan, Sperl, Annette, Spranger, Otto, Stelmach, Rafael, Suppli Ulrik, Charlotte Suppli, Thomas, Mike D., To, Teresa Md, Todo-Bom, A. Maria, Tomazic, Peter Valentin, Urrutia-Pereira, Marilyn, Valentin-Rostan, Marylin, van Ganse, Éric V., van Hage, Marianne, Vasankari, Tuula M., Vichyanond, Pakit, Viegi, Giovanni, Wallace, Dana V., Wang, de Yun, Williams, Siân, Worm, Margitta M., Yiallouros, Panayiotis K., Yusuf, Osman M., Zaitoun, Fares H., Zernotti, Mario Emilio, Zidarn, Mihaela, Zuberbier, Jaron, Fonseca, Joao A., Zuberbier, Torsten, Anto, Josep M.

المساهمون: Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

المصدر: ISSN: 0105-4538.

مصطلحات موضوعية: asthma, IL-33, multimorbidity, rhinitis, Toll-like receptors, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36799120; hal-04233296; https://hal.science/hal-04233296Test; PUBMED: 36799120

الإتاحة: https://doi.org/10.1111/all.15679Test
https://hal.science/hal-04233296Test

المؤلفون: Bousquet, Jean, Melén, E., Haahtela, Tari, Koppelman, G., Togias, A., Valenta, R., Akdis, C., Czarlewski, Wienczyslawa, Rothenberg, M., Valiulis, Arunas, Wickman, M., Akdis, M., Aguilar, D., Bedbrook, Anna, Bindslev-Jensen, C., Bosnic-Anticevich, Sinthia, Boulet, Louis-Philippe, Brightling, C., Brussino, Luisa, Burte, E., Bustamante, M., Canonica, G Walter, Cecchi, Lorenzo, Celedon, J., Chaves Loureiro, C., Costa, E., Cruz, Alvaro, Erhola, M., Gemicioglu, Bilun, Fokkens, W., Garcia-Aymerich, J., Guerra, S., Heinrich, J., Ivancevich, J., Keil, T., Klimek, Ludger, Kuna, Piotr, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Lemonnier, N., Lodrup Carlsen, K., Louis, Renaud, Makela, Mika, Makris, M., Maurer, M., Momas, I., Morais-Almeida, Mario, Mullol, J., Naclerio, R., Nadeau, K., Nadif, Rachel, Niedoszytko, Marek, Okamoto, Y., Ollert, M., Papadopoulos, Nikolaos, Passalacqua, G., Patella, V., Pawankar, R., Pham-Thi, Nhân, Pfaar, Oliver, Regateiro, Frederico, Ring, J., Rouadi, P., Samolinski, Boleslaw, Sastre, Joaquin, Savouré, M., Scichilone, Nicola, Shamji, Mohamed, Sheikh, Aziz, Siroux, V., Sousa-Pinto, Bernardo, Standl, M., Sunyer, J., Taborda-Barata, Luis, Toppila-Salmi, S., Torres, M., Tsiligianni, I., Valovirta, E., Vandenplas, Olivier, Ventura, Maria Teresa, Weiss, S., Yorgancioglu, Arzu, Zhang, L., Abdul Latiff, A., Aberer, W., Agache, Ioana, Al-Ahmad, M., Alobid, I., Ansotegui, I., Arshad, S., Asayag, E., Barbara, C., Baharudin, A., Battur, L., Bennoor, K., Berghea, E., Bergmann, Karl, Bernstein, D., Bewick, M., Blain, H., Bonini, Matteo, Braido, F., Buhl, Roland, Bumbacea, R., Bush, A., Calderon, M., Calvo-Gil, M., Camargos, P., Caraballo, L., Cardona, V., Carr, W., Carreiro-Martins, P., Casale, T., Cepeda Sarabia, A., Chandrasekharan, R., Charpin, Denis, Chen, Y., Cherrez-Ojeda, I., Chivato, T., Chkhartishvili, E., Christoff, G., Chu, D., Cingi, C., Correia de Sousa, J., Corrigan, C., Custovic, A., D’amato, G., del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, Didier, A., Do Ceu Teixeira, M., Dokic, D., Douagui, H., Doulaptsi, M., Durham, S., Dykewicz, M., Eiwegger, T., El-Sayed, Z., Emuzyte, R., Fiocchi, A., Fyhrquist, N., Gomez, R., Gotua, M., Guzman, M., Hagemann, J., Hamamah, S., Halken, S., Halpin, D., Hofmann, M., Hossny, E., Hrubiško, M., Irani, C., Ispayeva, Z., Jares, E., Jartti, T., Jassem, Ewa, Julge, K., Just, J., Jutel, Marek, Kaidashev, I., Kalayci, O., Kalyoncu, A., Kardas, P., Kirenga, B., Kraxner, H., Kull, I., Kulus, Marek, La Grutta, S., Lau, S., Le Tuyet Thi, L., Levin, M., Lipworth, B., Lourenço, O., Mahboub, B., Martinez-Infante, E., Matricardi, P., Miculinic, N., Migueres, N., Mihaltan, F., Mohammad, Y., Moniuszko, M., Montefort, S., Neffen, Hugo, Nekam, K., Nunes, E., Nyembue Tshipukane, D., O’hehir, R., Ogulur, I., Ohta, Ken, Okubo, K., Ouedraogo, S., Olze, H., Pali-Schöll, I., Palomares, O., Palosuo, K., Panaitescu, C., Panzner, P., Park, H., Pitsios, C., Plavec, D., Popov, T., Puggioni, Francesca, Quirce, S., Recto, M., Repka-Ramirez, M., Robalo Cordeiro, C., Roche, Nicolas, Rodriguez-Gonzalez, M., Romantowski, Jan, Rosario Filho, N., Rottem, M., Sagara, H., Serpa, F., Sayah, Z., Scheire, S., Schmid-Grendelmeier, P., Sisul, J., Sole, D., Soto-Martinez, M., Sova, M., Sperl, A., Spranger, O., Stelmach, R., Suppli Ulrik, C., Thomas, M., To, T., Todo-Bom, A., Tomazic, P., Urrutia-Pereira, M., Valentin-Rostan, M., van Ganse, E., van Hage, M., Vasankari, T., Vichyanond, P., Viegi, G., Wallace, D., Wang, D., Williams, S., Worm, M., Yiallouros, P., Yusuf, O., Zaitoun, F., Zernotti, M., Zidarn, M., Zuberbier, J., Fonseca, João, Zuberbier, Torsten, Anto, Josep

المساهمون: Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Foch Suresnes

المصدر: ISSN: 0105-4538.

مصطلحات موضوعية: asthma, IL-33, multimorbidity, rhinitis, Toll-like receptors, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36799120; hal-04260421; https://hal.science/hal-04260421Test; https://hal.science/hal-04260421/documentTest; https://hal.science/hal-04260421/file/Allergy_2023_Bousquet_Rhinitis_associated_with_asthma_is_distinct_from_rhinitis_alone_The_ARIA_MeDALL_hypothesis.pdfTest; PUBMED: 36799120

الإتاحة: https://doi.org/10.1111/all.15679Test
https://hal.science/hal-04260421Test
https://hal.science/hal-04260421/documentTest
https://hal.science/hal-04260421/file/Allergy_2023_Bousquet_Rhinitis_associated_with_asthma_is_distinct_from_rhinitis_alone_The_ARIA_MeDALL_hypothesis.pdfTest

المؤلفون: Sousa-Pinto, Bernardo, Louis, Renaud E., Anto, Josep María, Amaral, R., Sá-Sousa, Ana, Czarlewski, Wienczyslawa, Brussino, Luisa, Canonica, Walter G., Chaves Loureiro, Cláudia, Cruz, Álvaro Augusto, Gemicioglu, Bilun, Haahtela, Tari M.K., Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Désirée E.S., Okamoto, Y., Ollert, Markus W., Pfaar, Oliver, Pham-Thi, Nhân, Puggioni, Francesca A., Regateiro, Frederico Soares, Romantowski, Jan, Sastre, Joaquín, Scichilone, Nicola, Taborda-Barata, Luís Manuel, Ventura, M. T., Agache, Ioana O., Bedbrook, Anna, Becker, Sven, Bergmann, Karl Christian, Bosnic-Anticevich, Sinthia Zrinka, Bonini, Matteo, Boulet, Louis Philippe, Brusselle, Guy G.O., Buhl, Roland Otto, Cecchi, Lorenzo, Charpin, Denis André, de Blay, Frédéric J., del Giacco, Stefano R., Ivancevich, J. C., Jutel, Marek, Klimek, Ludger, Kraxner, Helga, Kuna, P. B., Laune, Daniel, Makela, Mika Juhani, Morais-Almeida, Riccardo A., Nadif, Rachel, Niedoszytko, Marek B., Papadopoulos, N. G., Papi, Alberto A., Patella, Vincenzo, Pétré, Benoît, Rivero Yeverino, Daniela, Robalo Cordeiro, Carlos, Roche, Nicolas, Rouadi, Philip W., Samolinski, Bolesław Krzysztof, Savouré, Marine, Shamji, Mohamed H., Sheikh, Aziz, Suppli Ulrik, Charlotte Suppli, Usmani, Omar Sharif, Valiulis, Arūnas, Yorgancioglu, Arzu A., Zuberbier, Thorsten, Fonseca, João Almeida, Costa, Elisio M., Bousquet, Jean J.

المساهمون: Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, American Heart Association, AHA, (H2020), EIT Health, HORIZON EUROPE Framework Programme, European Commission, EC

المصدر: ISSN: 2531-0429 ; Pulmonology ; https://hal.science/hal-04195104Test ; Pulmonology, 2023, ⟨10.1016/j.pulmoe.2023.07.004⟩.

مصطلحات موضوعية: Adherence, Asthma, Formoterol, Inhaled corticosteroids, Long-acting-β2 agonist, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA. Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day. Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001). Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37543524; hal-04195104; https://hal.science/hal-04195104Test; https://hal.science/hal-04195104/documentTest; https://hal.science/hal-04195104/file/1-s2.0-S2531043723001307-main.pdfTest; PUBMED: 37543524

الإتاحة: https://doi.org/10.1016/j.pulmoe.2023.07.004Test
https://hal.science/hal-04195104Test
https://hal.science/hal-04195104/documentTest
https://hal.science/hal-04195104/file/1-s2.0-S2531043723001307-main.pdfTest

المؤلفون: Bousquet, Jean J., Melén, Erik, Haahtela, Tari M.K., Koppelman, Gerard H., Togias, Alkis G., Valenta, Rudolf, Akdis, Cezmi Ali, Czarlewski, Wienczyslawa, Rothenberg, Marc E., Valiulis, Arūnas, Wickman, Magnus C., Akdis, Mübeccel, Aguilar, Daniel, Bedbrook, Anna, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia Zrinka, Boulet, Louis Philippe, Brightling, Christopher Edward, Brussino, Luisa, Burte, Emilie, Bustamante, Mariona, Canonica, Walter G., Cecchi, Lorenzo, Celedon, Juan Carlos, Chaves Loureiro, Cláudia, Costa, Elísio Sbardellotto Mariano Da, Cruz, Álvaro Augusto, Erhola, Marina L., Gemicioglu, Bilun, Fokkens, Wytske Johanna, Garcia-Aymerich, Judith M., Guerra, Stefano, Heinrich, Joachim, Ivancevich, J. C., Keil, Thomas, Klimek, Ludger, Kuna, P. B., Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Désirée E.S., Lemonnier, Nathanaël, Lodrup Carlsen, Karin Cecilie, Louis, Renaud E., Makela, Mika Juhani, Makris, Michael P., Maurer, Marcus, Momas, Isabelle, Morais-Almeida, Mário, Mullol, Joaquim, Naclerio, Robert M., Nadeau, Kari Christine, Nadif, Rachel, Niedoszytko, Marek B., Okamoto, Yoshitaka, Ollert, Markus W., Papadopoulos, Nikolaos G., Passalacqua, Giovanni G., Patella, Vincenzo, Pawankar, Ruby U., Pham-Thi, Nhân, Pfaar, Oliver, Regateiro, Frederico Soares, Ring, Johannes, Rouadi, Philip W., Samolinski, Bolesław Krzysztof, Sastre, Joaquín, Savouré, Marine, Scichilone, Nicola, Shamji, Mohamed H., Sheikh, Aziz, Siroux, Valérie, Sousa-Pinto, Bernardo, Standl, Marie, Sunyer, Jordi A., Taborda-Barata, Luís Manuel, Toppila-Salmi, Sanna Katriina, Torres, María José, Tsiligianni, Ioanna G., Valovirta, Erkka Juhani, Vandenplas, Olivier, Ventura, M. T., Weiss, Scott T., Yorgancioglu, Arzu A., Zhang, Luo, Abdul Latiff, Amir Hamzah, Aberer, Werner, Agache, Ioana O., Al-Ahmad, Mona S., Alobid, Isam, Ansotegui, Ignacio Javier, Arshad, Syed Hasan, Asayag, Estrella, Barbara, Cristina, Baharudin, Abdullah, Battur, Lkhagvaa, Bennoor, Kazi Saifuddin, Berghea, Elena Camelia, Bergmann, Karl Christian, Bernstein, David Isaac, Bewick, Michael, Blain, Hubert, Bonini, Matteo, Braido, Fulvio, Buhl, Roland Otto, Bumbacea, Roxana Silvia, Bush, Andrew P., Calderon, Moiśes A., Calvo-Gil, Mario A., Camargos, Paulo Augusto Moreira, Caraballo, Luis R., Cardona, Victoria, Carr, Warner W., Carreiro-Martins, Pedro, Casale, T. Bruce, Cepeda Sarabia, Alfonso Mario, Chandrasekharan, Ramanathan, Charpin, Denis André, Chen, Yuzhi, Cherrez-Ojeda, Ivan, Chivato, Tomas, Chkhartishvili, Ekaterine S., Christoff, George, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Corrigan, C. J., Custovic, Adnan, D’amato, Gennaro, del Giacco, Stefano Renato, de Blay, Frédéric J., Devillier, Philippe, Didier, Alain P., Do Ceu Teixeira, Maria, Dokic, Dejand, Douagui, Habib B., Doulaptsi, Maria V., Durham, Stephen R., Dykewicz, Mark S., Eiwegger, Thomas, El-Sayed, Zeinab Awad, Emuzyte, Regina, Fiocchi, Alessandro Giovanni, Fyhrquist, Nanna, Gomez, René Maximiliano, Gotua, Maia A., Guzman, María Antonieta, Hagemann, Jan Hendrik, Hamamah, Samir, Halken, Susanne, Halpin, David M.G., Hofmann, Maja Ann, Hossny, Elham M., Hrubiško, Martin, Irani, Carla, Ispayeva, Zhanat B., Jares, Edgardo José, Jartti, Tuomas T., Jassem, Ewa, Julge, Kaja, Just, Jocelyne, Jutel, Marek, Kaidashev, I. P., Kalayci, Ömer, Kalyoncu, Ali Fuat, Kardas, Przemysław, Kirenga, Bruce James, Kraxner, Helga, Kull, Inger, Kulus, Marek, La Grutta, Stefania, Lau, Susanne, Le Tuyet Thi, L., Levin, Michael E., Lipworth, Brian Jonathon, Lourenço, Olga, Mahboub, Bassam H., Martinez-Infante, Eric A., Matricardi, Paolo Maria, Miculinic, Neven, Migueres, Nicolas, Mihaltan, Florin Dumitru, Mohammad, Yousser, Moniuszko, Marcin, Montefort, Stephen R., Neffen, Hugo E., Nekam, Kristoff, Nunes, Elizabete Abrantes, Nyembue Tshipukane, Dieudonné, O’hehir, Robyn E., Ogulur, İsmail, Ohta, Ken, Okubo, Kimihiro, Ouedraogo, Solange Odile Yugbaré, Olze, Heidi, Pali-Schöll, Isabella Maria, Palomares, Óscar, Palosuo, Kati, Panaitescu, Carmen Bunu, Panzner, Petr, Park, Haesim, Pitsios, Constantinos, Plavec, Davor, Popov, T. A., Puggioni, Francesca A., Quirce, Santiago, Recto, Marysia Tiongco, Repka-Ramirez, María Susana, Robalo Cordeiro, Carlos, Roche, Nicolas, Rodriguez-Gonzalez, Mónica, Romantowski, Jan, Rosario Filho, Nelson Augusto, Rottem, Menachem, Sagara, Hironori, Serpa, Faradiba Sarquis, Sayah, Z., Scheire, Sophie, Schmid-Grendelmeier, Peter D., Sisul, Juan Carlos, Sole, Dirceu, Soto-Martinez, Manuel E., Sova, Milan, Sperl, Annette, Spranger, Otto, Stelmach, Rafael, Suppli Ulrik, Charlotte Suppli, Thomas, Mike D., To, Teresa Md, Todo-Bom, A. Maria, Tomazic, Peter Valentin, Urrutia-Pereira, Marilyn, Valentin-Rostan, Marylin, van Ganse, Éric V., van Hage, Marianne, Vasankari, Tuula M., Vichyanond, Pakit, Viegi, Giovanni, Wallace, Dana V., Wang, de Yun, Williams, Siân, Worm, Margitta M., Yiallouros, Panayiotis K., Yusuf, Osman M., Zaitoun, Fares H., Zernotti, Mario Emilio, Zidarn, Mihaela, Zuberbier, Jaron, Fonseca, Joao A., Zuberbier, Torsten, Anto, Josep M.

المساهمون: Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

المصدر: ISSN: 0105-4538.

مصطلحات موضوعية: asthma, IL-33, multimorbidity, rhinitis, Toll-like receptors, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36799120; hal-04233296; https://hal.science/hal-04233296Test; PUBMED: 36799120

الإتاحة: https://doi.org/10.1111/all.15679Test
https://hal.science/hal-04233296Test

المؤلفون: Chen, Wenjia, Tran, Trung, Sadatsafavi, Mohsen, Murray, Ruth, Wong, Nigel Chong Boon, Ali, Nasloon, Ariti, Con, Bulathsinhala, Lakmini, Gil, Esther Garcia, Fitzgerald, J. Mark, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne-Sofie, Bourdin, Arnaud, von Bülow, Anna, Busby, John, Walter Canonica, Giorgio, Carter, Victoria, Christoff, George, Cosio, Borja, Costello, Richard, Fonseca, João, Gibson, Peter, Yoo, Kwang-Ha, Heaney, Liam, Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David, Jones, Rupert, Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri, Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew, Newell, Anthony, Sirena, Concetta, Papadopoulos, Nikolaos, Papaioannou, Andriana, Perez-De-Llano, Luis, Peters, Matthew, Pfeffer, Paul, Porsbjerg, Celeste, Popov, Todor, Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos, Ulrik, Charlotte, Ra, Seung-Won, Wang, Eileen, Wechsler, Michael, Price, David

المساهمون: Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)

المصدر: The Journal of Allergy and Clinical Immunology: In Practice ; https://hal.science/hal-04124822Test ; The Journal of Allergy and Clinical Immunology: In Practice, 2023, ⟨10.1016/j.jaip.2023.05.044⟩

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience

العلاقة: hal-04124822; https://hal.science/hal-04124822Test; https://hal.science/hal-04124822/documentTest; https://hal.science/hal-04124822/file/2023%20Chen%20et%20al.,%20%20Impact%20of%20Inititing.pdfTest

الإتاحة: https://doi.org/10.1016/j.jaip.2023.05.044Test
https://hal.science/hal-04124822Test
https://hal.science/hal-04124822/documentTest
https://hal.science/hal-04124822/file/2023%20Chen%20et%20al.,%20%20Impact%20of%20Inititing.pdfTest

المؤلفون: Pfeffer, Paul, Ali, Nasloon, Murray, Ruth, Ulrik, Charlotte, Tran, Trung, Maspero, Jorge, Peters, Matthew, Christoff, George, Sadatsafavi, Mohsen, Torres-Duque, Carlos, Altraja, Alan, Lehtimäki, Lauri, Papadopoulos, Nikolaos, Salvi, Sundeep, Costello, Richard, Cushen, Breda, Heffler, Enrico, Iwanaga, Takashi, Al-Ahmad, Mona, Larenas-Linnemann, Désirée, Kuna, Piotr, Fonseca, João, Al-Lehebi, Riyad, Rhee, Chin Kook, Perez-De-Llano, Luis, Perng Steve, Diahn‐warng, Mahboub, Bassam, Wang, Eileen, Goh, Celine, Lyu, Juntao, Newell, Anthony, Alacqua, Marianna, Belevskiy, Andrey, Bhutani, Mohit, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, von Bulow, Anna, Busby, John, Canonica, Giorgio Walter, Cosio, Borja, Dorscheid, Del, Muñoz-Esquerre, Mariana, Fitzgerald, J. Mark, Gil, Esther Garcia, Gibson, Peter, Heaney, Liam, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Jackson, David, Koh, Mariko Siyue, Ko Bruce, Hsin‐kuo, Lee, Jae Ha, Lehmann, Sverre, Chaves Loureiro, Cláudia, Lúðvíksdóttir, Dóra, Menzies-Gow, Andrew, Mitchell, Patrick, Papaioannou, Andriana, Popov, Todor, Porsbjerg, Celeste, Salameh, Laila, Sirena, Concetta, Taillé, Camille, Taube, Christian, Tohda, Yuji, Wechsler, Michael, Price, David

المساهمون: Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)

المصدر: ISSN: 0105-4538.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

العلاقة: hal-04039334; https://hal.science/hal-04039334Test; https://hal.science/hal-04039334/documentTest; https://hal.science/hal-04039334/file/2023%20%20Pfeffer%20%20et%20al.,%20Comparative.pdfTest

الإتاحة: https://doi.org/10.1111/all.15711Test
https://hal.science/hal-04039334Test
https://hal.science/hal-04039334/documentTest
https://hal.science/hal-04039334/file/2023%20%20Pfeffer%20%20et%20al.,%20Comparative.pdfTest

المؤلفون: Cushen, Breda, Koh, Mariko Siyue, Tran, Trung, Martin, Neil, Murray, Ruth, Uthaman, Thendral, Goh, Celine Yun Yi, Vella, Rebecca, Eleangovan, Neva, Bulathsinhala, Lakmini, Maspero, Jorge, Peters, Matthew, Schleich, Florence, Pitrez, Paulo, Christoff, George, Sadatsafavi, Mohsen, Torres-Duque, Carlos, Porsbjerg, Celeste, Altraja, Alan, Lehtimäki, Lauri, Bourdin, Arnaud, Taube, Christian, Papadopoulos, Nikolaos, Zsuzsanna, Csoma, Björnsdóttir, Unnur, Salvi, Sundeep, Heffler, Enrico, Iwanaga, Takashi, Al-Ahmad, Mona, Larenas-Linnemann, Désirée, van Boven, Job Fm, Aarli, Bernt Bøgvald, Kuna, Piotr, Loureiro, Cláudia Chaves, Al-Lehebi, Riyad, Lee, Jae Ha, Marina, Nuria, Bjermer, Leif, Sheu, Chau-Chyun, Mahboub, Bassam, Busby, John, Menzies-Gow, Andrew, Wang, Eileen, Price, David

المساهمون: Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)

المصدر: ISSN: 1179-7266 ; Pragmatic and Observational Research ; https://hal.science/hal-04262313Test ; Pragmatic and Observational Research, 2023, Volume 14, pp.127-147. ⟨10.2147/POR.S399879⟩.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

العلاقة: hal-04262313; https://hal.science/hal-04262313Test; https://hal.science/hal-04262313/documentTest; https://hal.science/hal-04262313/file/2023%20%20Cushen%20et%20al.,%20Adult%20Severe%20Asthma%20Registries.pdfTest

الإتاحة: https://doi.org/10.2147/POR.S399879Test
https://hal.science/hal-04262313Test
https://hal.science/hal-04262313/documentTest
https://hal.science/hal-04262313/file/2023%20%20Cushen%20et%20al.,%20Adult%20Severe%20Asthma%20Registries.pdfTest