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أعرض في EDS

Benefits of Premaquick® Combined Detection of IL-6/Total IGFBP-1/Native IGFBP-1 to Predict Preterm Delivery

التفاصيل البيبلوغرافية
العنوان: Benefits of Premaquick® Combined Detection of IL-6/Total IGFBP-1/Native IGFBP-1 to Predict Preterm Delivery
المؤلفون: Pambet, Mathilde, Sirodot, Fanny, Pereira, Bruno, Cahierc, Romain, Delabaere, Amélie, Comptour, Aurélie, Rouzaire, Marion, Sapin, Vincent, Gallot, Denis
المساهمون: Unité de Biostatistiques CHU Clermont-Ferrand, Direction de la recherche clinique et de l’innovation CHU Clermont-Ferrand (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Service Obstétrique CHU Clermont-Ferrand, CHU Estaing Clermont-Ferrand, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne 2017-2020 (UCA 2017-2020 )-Centre National de la Recherche Scientifique (CNRS)
المصدر: ISSN: 2077-0383 ; Journal of Clinical Medicine ; https://hal.science/hal-04350517Test ; Journal of Clinical Medicine, 2023, 12 (17), pp.5707. ⟨10.3390/jcm12175707⟩.
بيانات النشر: HAL CCSD
MDPI
سنة النشر: 2023
المجموعة: Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe)
مصطلحات موضوعية: [SDV]Life Sciences [q-bio]
الوصف: We conducted a prospective double-blind study to compare two vaginal diagnostic methods in singleton pregnancies with threatened preterm labor (TPL) at the University Hospital of Clermont-Ferrand (France) from August 2018 to December 2020. Our main objective was to compare the diagnostic capacity at admission, in terms of positive predictive value (PPV) and negative predictive value (NPV), of Premaquick® (combined detection of IL-6/total IGFBP-1/native IGFBP-1) and QuikCheck fFN™ (fetal fibronectin) for delivery within 7 days in cases of TPL. We included 193 patients. Premaquick® had a sensitivity close to 89%, equivalent to QuikCheck fFN™, but a higher statistical specificity of 49.5% against 38.6% for QuikCheck fFN™. We found no superiority of Premaquick® over QuickCheck fFN™ in terms of PPV (6.6% vs. 7.9%), with NPV being equivalent in predicting childbirth within 7 days in cases of TPL (98.6% vs. 98.9%). Nevertheless, the combination of positive native and total IGFBP-1 and the combination of all three positive markers were associated with a higher PPV. Our results, though non-significant, support this combined multiple-biomarker approach to improve testing in terms of predictive values.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: hal-04350517; https://hal.science/hal-04350517Test
DOI: 10.3390/jcm12175707
الإتاحة: https://doi.org/10.3390/jcm12175707Test
https://hal.science/hal-04350517Test
رقم الانضمام: edsbas.D9648409
قاعدة البيانات: BASE
الوصف
DOI:10.3390/jcm12175707