التفاصيل البيبلوغرافية
| العنوان: |
Critical assessment of protein intrinsic disorder prediction |
| المؤلفون: |
Necci, Marco, Piovesan, Damiano, Tosatto, Silvio, C E, Hoque, Md Tamjidul, Walsh, Ian, Iqbal, Sumaiya, Vendruscolo, Michele, Sormanni, Pietro, Wang, Chen, Raimondi, Daniele, Sharma, Ronesh, Zhou, Yaoqi, Litfin, Thomas, Galzitskaya, Oxana Valerianovna, Lobanov, Michail Yu., Vranken, Wim, Wallner, Björn, Mirabello, Claudio, Malhis, Nawar, Dosztányi, Zsuzsanna, Erdős, Gábor, Mészáros, Bálint, Gao, Jianzhao, Wang, Kui, Hu, Gang, Wu, Zhonghua, Sharma, Alok, Hanson, Jack, Paliwal, Kuldip, Callebaut, Isabelle, Bitard-Feildel, Tristan, Orlando, Gabriele, Peng, Zhenling, Xu, Jinbo, Wang, Sheng, Jones, David T., Cozzetto, Domenico, Meng, Fanchi, Yan, Jing, Gsponer, Jörg, Cheng, Jianlin, Wu, Tianqi, Kurgan, Lukasz, Promponas, Vasilis J., Tamana, Stella, Marino-Buslje, Cristina, Martínez-Pérez, Elizabeth, Chasapi, Anastasia, Ouzounis, Christos, Dunker, A. Keith, Kajava, Andrey V., Leclercq, Jeremy Y., Aykac-Fas, Burcu, Lambrughi, Matteo, Maiani, Emiliano, Papaleo, Elena, Chemes, Lucia Beatriz, Álvarez, Lucía, González-Foutel, Nicolás S., Iglesias, Valentin, Pujols, Jordi, Ventura, Salvador, Palopoli, Nicolás, Benítez, Guillermo Ignacio, Parisi, Gustavo, Bassot, Claudio, Elofsson, Arne, Govindarajan, Sudha, Lamb, John, Salvatore, Marco, Hatos, András, Monzon, Alexander Miguel, Bevilacqua, Martina, Mičetić, Ivan, Minervini, Giovanni, Paladin, Lisanna, Quaglia, Federica, Leonardi, Emanuela, Davey, Norman, Horvath, Tamas, Kovacs, Orsolya Panna, Murvai, Nikoletta, Pancsa, Rita, Schad, Eva, Szabo, Beata, Tantos, Agnes, Macedo-Ribeiro, Sandra, Manso, Jose Antonio, Pereira, Pedro José Barbosa, Davidović, Radoslav, Veljkovic, Nevena, Hajdu-Soltész, Borbála, Pajkos, Mátyás, Szaniszló, Tamás, Guharoy, Mainak, Lazar, Tamas, Macossay-Castillo, Mauricio, Tompa, Peter |
| المساهمون: |
Università degli Studi di Padova = University of Padua (Unipd), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement IRD : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ANR-17-CE12-0016,FUNBRCA2,Caractérisation d'un nouveau site de liaison à l'ADN dans la protéine BRCA2(2017) |
| المصدر: |
ISSN: 1548-7091. |
| بيانات النشر: |
HAL CCSD
Nature Publishing Group |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Computational platforms and environments, Machine learning, Protein structure predictions, Proteins, Software, MESH: Amino Acid Sequence, MESH: Computational Biology, MESH: Databases, Protein, MESH: Intrinsically Disordered Proteins, MESH: Protein Binding, MESH: Protein Conformation, MESH: Protein Folding, MESH: Software, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs] |
| الوصف: |
International audience ; Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial that their accuracy is high. The Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment was established as a community-based blind test to determine the state of the art in prediction of intrinsically disordered regions and the subset of residues involved in binding. A total of 43 methods were evaluated on a dataset of 646 proteins from DisProt. The best methods use deep learning techniques and notably outperform physicochemical methods. The top disorder predictor has F max = 0.483 on the full dataset and F max = 0.792 following filtering out of bona fide structured regions. Disordered binding regions remain hard to predict, with F max = 0.231. Interestingly, computing times among methods can vary by up to four orders of magnitude. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/33875885; hal-03329755; https://hal.sorbonne-universite.fr/hal-03329755Test; https://hal.sorbonne-universite.fr/hal-03329755v2/documentTest; https://hal.sorbonne-universite.fr/hal-03329755v2/file/Necci%20et%20al.%20-%202021%20-%20Critical%20assessment%20of%20protein%20intrinsic%20disorder%20.pdfTest; PUBMED: 33875885; PUBMEDCENTRAL: PMC8105172 |
| DOI: |
10.1038/s41592-021-01117-3 |
| الإتاحة: |
https://doi.org/10.1038/s41592-021-01117-3Test
https://hal.sorbonne-universite.fr/hal-03329755Test
https://hal.sorbonne-universite.fr/hal-03329755v2/documentTest
https://hal.sorbonne-universite.fr/hal-03329755v2/file/Necci%20et%20al.%20-%202021%20-%20Critical%20assessment%20of%20protein%20intrinsic%20disorder%20.pdfTest |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.AE3D921B |
| قاعدة البيانات: |
BASE |
