المؤلفون: Chen, Sing-Young, Beretta, Martina, Olzomer, Ellen M., Alexopoulos, Stephanie J., Shah, Divya P., Byrne, Frances L., Salamoun, Joseph M., Garcia, Christopher J., Smith, Greg C., Larance, Mark, Philp, Andrew, Turner, Nigel, Santos, Webster L., Cantley, James, Hoehn, Kyle L.

المصدر: Chen , S-Y , Beretta , M , Olzomer , E M , Alexopoulos , S J , Shah , D P , Byrne , F L , Salamoun , J M , Garcia , C J , Smith , G C , Larance , M , Philp , A , Turner , N , Santos , W L , Cantley , J & Hoehn , K L 2024 , ' Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice ' , BBA - Molecular Basis of Disease , vol. 1870 ....

مصطلحات موضوعية: Mitochondrial uncoupling, Diabetes, Obesity, GLP-1, Calorie restriction, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/b653b5a5-e77e-47fb-ac5d-7995a51b5f3cTest

الإتاحة: https://doi.org/10.1016/j.bbadis.2023.166908Test
https://discovery.dundee.ac.uk/en/publications/b653b5a5-e77e-47fb-ac5d-7995a51b5f3cTest
https://discovery.dundee.ac.uk/ws/files/108817961/1-s2.0-S0925443923002740-main.pdfTest
http://www.scopus.com/inward/record.url?scp=85172989886&partnerID=8YFLogxKTest

المؤلفون: Silvaieh, Sara, König, Theresa, Wurm, Raphael, Parvizi, Tandis, Berger-Sieczkowski, Evelyn, Goeschl, Stella, Hotzy, Christoph, Wagner, Matias, Berutti, Riccardo, Sammler, Esther, Stögmann, Elisabeth, Zimprich, Alexander

المصدر: Silvaieh , S , König , T , Wurm , R , Parvizi , T , Berger-Sieczkowski , E , Goeschl , S , Hotzy , C , Wagner , M , Berutti , R , Sammler , E , Stögmann , E & Zimprich , A 2023 , ' Correction : Comprehensive genetic screening of early-onset dementia patients in an Austrian cohort-suggesting new disease-contributing genes (Human Genomics, (2023), 17, 1, (55), 10.1186/s40246-023-00499-z) ' , Human genomics , vol. 17 , 79 , pp. 1-5 . https://doi.org/10.1186/s40246-023-00525-0Test

مصطلحات موضوعية: /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1311, name=Genetics, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/183848e4-e5b9-4bb2-b4a6-8a9a908fd3eeTest

الإتاحة: https://doi.org/10.1186/s40246-023-00525-0Test
https://doi.org/10.1186/s40246-023-00499-zTest
https://discovery.dundee.ac.uk/en/publications/183848e4-e5b9-4bb2-b4a6-8a9a908fd3eeTest
https://discovery.dundee.ac.uk/ws/files/107251281/s40246-023-00525-0.pdfTest
http://www.scopus.com/inward/record.url?scp=85168784110&partnerID=8YFLogxKTest

المؤلفون: Silvaieh, Sara, König, Theresa, Wurm, Raphael, Parvizi, Tandis, Berger-Sieczkowski, Evelyn, Goeschl, Stella, Hotzy, Christoph, Wagner, Matias, Berutti, Riccardo, Sammler, Esther, Stögmann, Elisabeth, Zimprich, Alexander

المصدر: Silvaieh , S , König , T , Wurm , R , Parvizi , T , Berger-Sieczkowski , E , Goeschl , S , Hotzy , C , Wagner , M , Berutti , R , Sammler , E , Stögmann , E & Zimprich , A 2023 , ' Comprehensive genetic screening of early-onset dementia patients in an Austrian cohort-suggesting new disease-contributing genes ' , Human genomics , vol. 17 , 55 . https://doi.org/10.1186/s40246-023-00499-zTest

مصطلحات موضوعية: Humans, Aged, Alzheimer Disease/genetics, Amyloid Precursor Protein Secretases/genetics, Genetic Predisposition to Disease, Austria, Aspartic Acid Endopeptidases/genetics, Genetic Testing, Mutation, LDL-Receptor Related Proteins/genetics, Membrane Transport Proteins/genetics, Whole-exome sequencing, Early-onset dementia, Genetic variants, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1311, name=Genetics, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/44974984-57df-4611-94ba-7d3b2f1d478dTest

الإتاحة: https://doi.org/10.1186/s40246-023-00499-zTest
https://discovery.dundee.ac.uk/en/publications/44974984-57df-4611-94ba-7d3b2f1d478dTest
https://discovery.dundee.ac.uk/ws/files/105399458/s40246-023-00499-z.pdfTest
http://www.scopus.com/inward/record.url?scp=85162165733&partnerID=8YFLogxKTest

المؤلفون: Röth, Sascha, Kocaturk, Nur Mehpare, Sathyamurthi, Preethi S., Carton, Bill, Watt, Matthew, Macartney, Thomas J., Chan, Kwok-Ho, Isidro-Llobet, Albert, Konopacka, Agnieszka, Queisser, Markus A., Sapkota, Gopal P.

المصدر: Röth , S , Kocaturk , N M , Sathyamurthi , P S , Carton , B , Watt , M , Macartney , T J , Chan , K-H , Isidro-Llobet , A , Konopacka , A , Queisser , M A & Sapkota , G P 2023 , ' Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3 ' , Cell Chemical Biology , vol. 30 , no. 10 , pp. 1261-1276.e7 . https://doi.org/10.1016/j.chembiol.2023.07.006Test

مصطلحات موضوعية: RAS, STK33, β-catenin, FoxP3, PROTAC, KLHDC2, TPD, degron, E3 ligase, cancer, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/cce1c275-76ee-4fb5-93f7-4f392856e213Test

الإتاحة: https://doi.org/10.1016/j.chembiol.2023.07.006Test
https://discovery.dundee.ac.uk/en/publications/cce1c275-76ee-4fb5-93f7-4f392856e213Test
https://discovery.dundee.ac.uk/ws/files/115194467/PIIS2451945623002337.pdfTest
http://www.scopus.com/inward/record.url?scp=85173796751&partnerID=8YFLogxKTest

المؤلفون: Gola, Lukas, Bierhansl, Laura, Csatári, Júlia, Schroeter, Christina B., Korn, Lisanne, Narayanan, Venu, Cerina, Manuela, Abdolahi, Sara, Speicher, Anna, Hermann, Alexander M., König, Simone, Dinkova-Kostova, Albena T., Shekh-Ahmad, Tawfeeq, Meuth, Sven G., Wiendl, Heinz, Gorji, Ali, Pawlowski, Matthias, Kovac, Stjepana

المصدر: Gola , L , Bierhansl , L , Csatári , J , Schroeter , C B , Korn , L , Narayanan , V , Cerina , M , Abdolahi , S , Speicher , A , Hermann , A M , König , S , Dinkova-Kostova , A T , Shekh-Ahmad , T , Meuth , S G , Wiendl , H , Gorji , A , Pawlowski , M & Kovac , S 2023 , ' NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores ' , Cellular and Molecular Life Sciences , vol. 80 , no. ....

مصطلحات موضوعية: Calcium signaling, Hyperexcitability, Mitochondria, NADPH oxidase-4 (NOX4), Neurodegeneration, Reactive oxygen species (ROS), /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology, /dk/atira/pure/subjectarea/asjc/2800/2804, name=Cellular and Molecular Neuroscience, /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cell Biology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/19fada13-ac07-44ba-bd04-811947ccef2dTest

الإتاحة: https://doi.org/10.1007/s00018-023-04758-zTest
https://discovery.dundee.ac.uk/en/publications/19fada13-ac07-44ba-bd04-811947ccef2dTest
https://discovery.dundee.ac.uk/ws/files/101662069/s00018_023_04758_z.pdfTest
http://www.scopus.com/inward/record.url?scp=85153444985&partnerID=8YFLogxKTest

المؤلفون: Di Nisio, Elena, Licursi, Valerio, Mannironi, Cecilia, Buglioni, Valentina, Paiardini, Alessandro, Robusti, Giulia, Noberini, Roberta, Bonaldi, Tiziana, Negri, Rodolfo

المصدر: Di Nisio , E , Licursi , V , Mannironi , C , Buglioni , V , Paiardini , A , Robusti , G , Noberini , R , Bonaldi , T & Negri , R 2023 , ' A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression ' , Cancer Gene Therapy , vol. 30 , no. 6 , pp. 822–832 . https://doi.org/10.1038/s41417-022-00584-wTest

مصطلحات موضوعية: Breast cancer, Cell biology, Gene expression analysis, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1306, name=Cancer Research

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/4dfe0727-557c-4646-8afa-f53533e48661Test

الإتاحة: https://doi.org/10.1038/s41417-022-00584-wTest
https://discovery.dundee.ac.uk/en/publications/4dfe0727-557c-4646-8afa-f53533e48661Test
https://discovery.dundee.ac.uk/ws/files/95424569/s41417_022_00584_w.pdfTest
http://www.scopus.com/inward/record.url?scp=85146853977&partnerID=8YFLogxKTest

المؤلفون: Simpson, Luke M., Fulcher, Luke J., Sathe, Gajanan, Brewer, Abigail, Zhao, Jin-Feng, Squair, Daniel R., Crooks, Jennifer, Wightman, Melanie, Wood, Nicola T., Gourlay, Robert, Varghese, Joby, Soares, Renata F., Sapkota, Gopal P.

المصدر: Simpson , L M , Fulcher , L J , Sathe , G , Brewer , A , Zhao , J-F , Squair , D R , Crooks , J , Wightman , M , Wood , N T , Gourlay , R , Varghese , J , Soares , R F & Sapkota , G P 2023 , ' An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation ' , Cell Chemical Biology , vol. 30 , no. 2 , pp. 188-202 . https://doi.org/10.1016/j.chembiol.2023.01.003Test

مصطلحات موضوعية: Affinity-directed phosphatase, AdPhosphatase, Targeted dephosphorylation, PPP1CA, PPP2CA, Nanobody, ULK1, FAM83D, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/b0ee5ed6-6d18-4e15-bd77-1c5b5ba96ccaTest

الإتاحة: https://doi.org/10.1016/j.chembiol.2023.01.003Test
https://discovery.dundee.ac.uk/en/publications/b0ee5ed6-6d18-4e15-bd77-1c5b5ba96ccaTest
https://discovery.dundee.ac.uk/ws/files/96764889/1_s2.0_S2451945623000260_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85148030514&partnerID=8YFLogxKTest

المؤلفون: Madden, Sarah, Brennan, Andrew, Mason, Jody M.

المصدر: Madden , S , Brennan , A & Mason , J M 2023 , ' A library-derived peptide inhibitor of the BZLF1 transcription factor ' , Journal of Peptide Science . https://doi.org/10.1002/psc.3557Test

مصطلحات موضوعية: BZLF1, PCA, ZEBRA, peptide antagonists, peptide screening, transcription factor, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1315, name=Structural Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

العلاقة: https://researchportal.bath.ac.uk/en/publications/79c74d26-cbdd-4383-90cf-586bb3f16450Test

الإتاحة: https://doi.org/10.1002/psc.3557Test
https://researchportal.bath.ac.uk/en/publications/79c74d26-cbdd-4383-90cf-586bb3f16450Test
http://www.scopus.com/inward/record.url?scp=85178479901&partnerID=8YFLogxKTest

المؤلفون: Simpson, Luke M., Glennie, Lorraine, Brewer, Abigail, Zhao, Jin-Feng, Crooks, Jennifer, Shpiro, Natalia, Sapkota, Gopal P.

المصدر: Simpson , L M , Glennie , L , Brewer , A , Zhao , J-F , Crooks , J , Shpiro , N & Sapkota , G P 2022 , ' Target protein localization and its impact on PROTAC-mediated degradation ' , Cell Chemical Biology , vol. 29 , no. 10 , pp. 1482-1504.e7 . https://doi.org/10.1016/j.chembiol.2022.08.004Test

مصطلحات موضوعية: proteolysis-targeting chimera (PROTAC), Targeted protein degradation (TPD), protein localization, degrader, dTAG, Halo, VHL, cereblon, CRBN, E3, HiBiT, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/1b78f0bd-7662-418b-a4d9-33149454ca2aTest

الإتاحة: https://doi.org/10.1016/j.chembiol.2022.08.004Test
https://discovery.dundee.ac.uk/en/publications/1b78f0bd-7662-418b-a4d9-33149454ca2aTest
https://discovery.dundee.ac.uk/ws/files/80555670/PIIS2451945622003129.pdfTest
http://www.scopus.com/inward/record.url?scp=85140068494&partnerID=8YFLogxKTest

المؤلفون: Chan, Peter W. Y., Chakrabarti, Nilmadhab, Ing, Chris, Halgas, Ondrej, To, Terence K. W., Wälti, Marielle, Petit, Alain-Pierre, Tran, Christopher, Savchenko, Alexei, Yakunin, Alexander F., Edwards, Elizabeth A., Pomès, Régis, Pai, Emil F.

المصدر: Chan , P W Y , Chakrabarti , N , Ing , C , Halgas , O , To , T K W , Wälti , M , Petit , A-P , Tran , C , Savchenko , A , Yakunin , A F , Edwards , E A , Pomès , R & Pai , E F 2022 , ' Defluorination Capability of l-2-Haloacid Dehalogenases in the HAD-Like Hydrolase Superfamily Correlates with Active Site Compactness ' , ChemBioChem , vol. 23 , no. 1 , e202100414 . https://doi.org/10.1002/cbic.202100414Test

مصطلحات موضوعية: enzyme catalysis, enzymic defluorination, L-2-haloacid dehalogenases, molecular dynamics, protein structures, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

العلاقة: https://discovery.dundee.ac.uk/en/publications/34c2e792-c3a2-4bcf-8f36-0f28f3f3329cTest

الإتاحة: https://doi.org/10.1002/cbic.202100414Test
https://discovery.dundee.ac.uk/en/publications/34c2e792-c3a2-4bcf-8f36-0f28f3f3329cTest
http://www.scopus.com/inward/record.url?scp=85117465831&partnerID=8YFLogxKTest