المؤلفون: Webb, Thomas, Craigon, Conner, Ciulli, Alessio

المصدر: Webb , T , Craigon , C & Ciulli , A 2022 , ' Targeting Epigenetic Modulators Using PROTAC Degraders : Current Status and Future Perspective ' , Bioorganic & Medicinal Chemistry Letters , vol. 63 , 128653 . https://doi.org/10.1016/j.bmcl.2022.128653Test

مصطلحات موضوعية: Chromatin, Degraders, Epigenetics, GNJIONZKYKHKNJ-UHFFFAOYSA-N, HDCCMCFIGHIDJR-TUDDPRDOSA-N, IJHBBPTVQYEAGQ-MSDWBBBCSA-N, ILVRLRGBSSFKIE-UHFFFAOYSA-N, IVARZBJJMMUJHI-SQKKEFIPSA-N, LONVYJSHGSZBQY-UHFFFAOYSA-N, Multiprotein complexes, PROTACs, Targeted protein degradation, Therapeutics, XQVSBRMMLVXWSD-UHFFFAOYSA-N, YABKDZZQDGCZTF-YUIXOWAOSA-N, ZAGCLFXBHOXXEN-JPTLTNPLSA-N, ZGCCNKFVHQHHRK-ZWHPVRQASA-N, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/1600/1605

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/a396bb08-21d7-4acd-92ad-b99077eb10fcTest

الإتاحة: https://doi.org/10.1016/j.bmcl.2022.128653Test
https://discovery.dundee.ac.uk/en/publications/a396bb08-21d7-4acd-92ad-b99077eb10fcTest
https://discovery.dundee.ac.uk/ws/files/73258206/1_s2.0_S0960894X22001299_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85125992464&partnerID=8YFLogxKTest

المؤلفون: Soliman, Aiten M., Mekkawy, Mai H., Karam, Heba M., Higgins, Maureen, Dinkova-kostova, Albena T., Ghorab, Mostafa M.

المصدر: Soliman , A M , Mekkawy , M H , Karam , H M , Higgins , M , Dinkova-kostova , A T & Ghorab , M M 2021 , ' Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress ' , Bioorganic & Medicinal Chemistry Letters , vol. 42 , 128002 . https://doi.org/10.1016/j.bmcl.2021.128002Test

مصطلحات موضوعية: Docking, Iodinated quinazolinones, NQO1, ROS, Radioprotective activity, Sulfonamide, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/01d17057-a74c-4d77-95d0-3d676f2b2944Test

الإتاحة: https://doi.org/10.1016/j.bmcl.2021.128002Test
https://discovery.dundee.ac.uk/en/publications/01d17057-a74c-4d77-95d0-3d676f2b2944Test
https://discovery.dundee.ac.uk/ws/files/57721756/1_s2.0_S0960894X21002286_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85105357972&partnerID=8YFLogxKTest

المؤلفون: Hatcher, John M., Zwirek, Monika, Sarhan, Adil R., Vatsan, Prasanna S., Tonelli, Francesca, Alessi, Dario R., Davies, Paul, Gray, Nathanael S.

المصدر: Hatcher , J M , Zwirek , M , Sarhan , A R , Vatsan , P S , Tonelli , F , Alessi , D R , Davies , P & Gray , N S 2023 , ' Development of a highly potent and selective degrader of LRRK2 ' , Bioorganic & Medicinal Chemistry Letters , vol. 94 , 129449 . https://doi.org/10.1016/j.bmcl.2023.129449Test

مصطلحات موضوعية: LRRK2, LRRK2 degrader, MLi-2, PROTAC, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

العلاقة: https://discovery.dundee.ac.uk/en/publications/20fc0f2b-b51b-42c4-b799-add7d51d99d9Test

الإتاحة: https://doi.org/10.1016/j.bmcl.2023.129449Test
https://discovery.dundee.ac.uk/en/publications/20fc0f2b-b51b-42c4-b799-add7d51d99d9Test

المؤلفون: Luise, Nicola, Wyatt, Paul G.

المصدر: Luise , N & Wyatt , P G 2019 , ' Diversity-oriented synthesis of bicyclic fragments containing privileged azines ' , Bioorganic & Medicinal Chemistry Letters , vol. 29 , no. 2 , pp. 248-251 . https://doi.org/10.1016/j.bmcl.2018.11.046Test

مصطلحات موضوعية: Diversity-oriented synthesis, Drug discovery, Fused-ring system, Heterocycles, Synthetic methods, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/9ada9834-609d-45d6-814a-9498c2022068Test

الإتاحة: https://doi.org/10.1016/j.bmcl.2018.11.046Test
https://discovery.dundee.ac.uk/en/publications/9ada9834-609d-45d6-814a-9498c2022068Test
https://discovery.dundee.ac.uk/ws/files/29556635/1_s2.0_S0960894X18309235_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85057251525&partnerID=8YFLogxKTest

المؤلفون: Girardini, Miriam, Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Ciulli, Alessio

المصدر: Girardini , M , Maniaci , C , Hughes , S J , Testa , A & Ciulli , A 2019 , ' Cereblon versus VHL : Hijacking E3 ligases against each other using PROTACs ' , Bioorganic & Medicinal Chemistry , vol. 27 , no. 12 , pp. 2466-2479 . https://doi.org/10.1016/j.bmc.2019.02.048Test

مصطلحات موضوعية: Cereblon, E3 ubiquitin ligases, PROTACs, Targeted protein degradation, von Hippel-Lindau protein, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/199369da-c860-479c-a36a-26de3eba2572Test

الإتاحة: https://doi.org/10.1016/j.bmc.2019.02.048Test
https://discovery.dundee.ac.uk/en/publications/199369da-c860-479c-a36a-26de3eba2572Test
https://discovery.dundee.ac.uk/ws/files/51813362/1_s2.0_S0968089619301725_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85062045136&partnerID=8YFLogxKTest

المؤلفون: Osborne, Joanne, Birchall, Kristian, Tsagris, Denise J., Lewis, Stephen J., Smiljanic-Hurley, Ela, Taylor, Debra L., Levy, Alison, Alessi, Dario, McIver, Edward G.

المصدر: Osborne , J , Birchall , K , Tsagris , D J , Lewis , S J , Smiljanic-Hurley , E , Taylor , D L , Levy , A , Alessi , D & McIver , E G 2019 , ' Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1 ' , Bioorganic & Medicinal Chemistry Letters , vol. 29 , no. 4 , pp. 668-673 . https://doi.org/10.1016/j.bmcl.2018.11.058Test

مصطلحات موضوعية: Parkinson’s Disease, G2019S, Kinase inhibitor, LLE, Parkinson's disease, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/c57b5ae0-cc95-488e-b8ba-8c8cbd56bab8Test

الإتاحة: https://doi.org/10.1016/j.bmcl.2018.11.058Test
https://discovery.dundee.ac.uk/en/publications/c57b5ae0-cc95-488e-b8ba-8c8cbd56bab8Test
https://discovery.dundee.ac.uk/ws/files/42460045/1_s2.0_S0960894X1830934X_main.pdfTest

المؤلفون: Alturki, Mansour S., Fuanta, Ngolui Rene, Jarrard, Madison A., Hobrath, Judith V., Goodwin, Douglas C., Rants'o, Thankhoe A., Calderón, Angela I.

المصدر: Alturki , M S , Fuanta , N R , Jarrard , M A , Hobrath , J V , Goodwin , D C , Rants'o , T A & Calderón , A I 2018 , ' A multifaceted approach to identify non-specific enzyme inhibition : Application to Mycobacterium tuberculosis shikimate kinase ' , Bioorganic and Medicinal Chemistry Letters , vol. 28 , no. 4 , pp. 802-808 . https://doi.org/10.1016/j.bmcl.2017.12.002Test

مصطلحات موضوعية: Aggregator, LC-MS, MtSK, NMR, Non-specific inhibition, Triton X-100, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/ef521418-fef6-49c6-b302-b1863c60ebb3Test

الإتاحة: https://doi.org/10.1016/j.bmcl.2017.12.002Test
https://discovery.dundee.ac.uk/en/publications/ef521418-fef6-49c6-b302-b1863c60ebb3Test
https://discovery.dundee.ac.uk/ws/files/20055167/1_s2.0_S0960894X17311629_main.pdfTest

المؤلفون: Bell, Mark, Foley, David, Naylor, Claire, Robinson, Colin, Riley, Jennifer, Epemolu, Rafiu, Scullion, Stanley, Shishikura, Yoko, Katz, Elad, McLean, William, Wyatt, Paul, Read, Kevin, Woodland, Christopher

المصدر: Bell , M , Foley , D , Naylor , C , Robinson , C , Riley , J , Epemolu , R , Scullion , S , Shishikura , Y , Katz , E , McLean , W , Wyatt , P , Read , K & Woodland , C 2018 , ' Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1 ' , Bioorganic & Medicinal Chemistry Letters , vol. 28 , no. 19 , pp. 3255-3259 . https://doi.org/10.1016/j.bmcl.2018.07.044Test

مصطلحات موضوعية: Plasma stability, Psoriasis, S1PR1, Soft-drug, Topical, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/4411ff61-b3f6-4d89-8c2f-74685b5fcf1eTest

الإتاحة: https://doi.org/10.1016/j.bmcl.2018.07.044Test
https://discovery.dundee.ac.uk/en/publications/4411ff61-b3f6-4d89-8c2f-74685b5fcf1eTest
https://discovery.dundee.ac.uk/ws/files/28095379/1_s2.0_S0960894X18306395_main.pdfTest
https://discovery.dundee.ac.uk/ws/files/34183764/1_s2.0_S0960894X18306395_main.pdfTest

المؤلفون: Soares, Pedro, Lucas, Xavier, Ciulli, Alessio

المصدر: Soares , P , Lucas , X & Ciulli , A 2018 , ' Thioamide substitution to probe the hydroxyproline recognition of VHL ligands ' , Bioorganic & Medicinal Chemistry , vol. 26 , no. 11 , pp. 2992-2995 . https://doi.org/10.1016/j.bmc.2018.03.034Test

مصطلحات موضوعية: n → π interaction, PROTACs, Protein-ligand interactions, Thioamides, VHL ligands, Hydroxyproline/chemistry, Drug Stability, Humans, Von Hippel-Lindau Tumor Suppressor Protein/chemistry, Crystallography, X-Ray, Hydrogen Bonding, Protein Binding, Ligands, Thioamides/chemistry, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/7da032bb-7f6f-444e-940b-c3faadd9d8a1Test

الإتاحة: https://doi.org/10.1016/j.bmc.2018.03.034Test
https://discovery.dundee.ac.uk/en/publications/7da032bb-7f6f-444e-940b-c3faadd9d8a1Test
https://discovery.dundee.ac.uk/ws/files/29904315/1_s2.0_S0968089618303481_main.pdfTest

المؤلفون: Bensasson, René V., Dinkova-Kostova, Albena T., Zheng, Suqing, Saito, Akira, Li, Wei, Zoete, Vincent, Honda, Tadashi

المصدر: Bensasson , R V , Dinkova-Kostova , A T , Zheng , S , Saito , A , Li , W , Zoete , V & Honda , T 2016 , ' Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme ' , Bioorganic & Medicinal Chemistry Letters , vol. 26 , no. 17 , pp. 4345-4349 . https://doi.org/10.1016/j.bmcl.2016.07.028Test

مصطلحات موضوعية: Electron affinity, Energy of the lowest unoccupied molecular orbital, Keap1/Nrf2/ARE pathway, NAD(P)H:quinone oxidoreductase 1 (NQO1) inducer, Nrf2 activator, QSAR, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/b7d62a69-9a06-41d8-ab08-57931594607eTest

الإتاحة: https://doi.org/10.1016/j.bmcl.2016.07.028Test
https://discovery.dundee.ac.uk/en/publications/b7d62a69-9a06-41d8-ab08-57931594607eTest
https://discovery.dundee.ac.uk/ws/files/9826921/1_s2.0_S0960894X16307417_main.pdfTest
http://www.scopus.com/inward/record.url?scp=84979272993&partnerID=8YFLogxKTest