المؤلفون: Röth, Sascha, Kocaturk, Nur Mehpare, Sathyamurthi, Preethi S., Carton, Bill, Watt, Matthew, Macartney, Thomas J., Chan, Kwok-Ho, Isidro-Llobet, Albert, Konopacka, Agnieszka, Queisser, Markus A., Sapkota, Gopal P.

المصدر: Röth , S , Kocaturk , N M , Sathyamurthi , P S , Carton , B , Watt , M , Macartney , T J , Chan , K-H , Isidro-Llobet , A , Konopacka , A , Queisser , M A & Sapkota , G P 2023 , ' Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3 ' , Cell Chemical Biology , vol. 30 , no. 10 , pp. 1261-1276.e7 . https://doi.org/10.1016/j.chembiol.2023.07.006Test

مصطلحات موضوعية: RAS, STK33, β-catenin, FoxP3, PROTAC, KLHDC2, TPD, degron, E3 ligase, cancer, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/cce1c275-76ee-4fb5-93f7-4f392856e213Test

الإتاحة: https://doi.org/10.1016/j.chembiol.2023.07.006Test
https://discovery.dundee.ac.uk/en/publications/cce1c275-76ee-4fb5-93f7-4f392856e213Test
https://discovery.dundee.ac.uk/ws/files/115194467/PIIS2451945623002337.pdfTest
http://www.scopus.com/inward/record.url?scp=85173796751&partnerID=8YFLogxKTest

المؤلفون: Simpson, Luke M., Fulcher, Luke J., Sathe, Gajanan, Brewer, Abigail, Zhao, Jin-Feng, Squair, Daniel R., Crooks, Jennifer, Wightman, Melanie, Wood, Nicola T., Gourlay, Robert, Varghese, Joby, Soares, Renata F., Sapkota, Gopal P.

المصدر: Simpson , L M , Fulcher , L J , Sathe , G , Brewer , A , Zhao , J-F , Squair , D R , Crooks , J , Wightman , M , Wood , N T , Gourlay , R , Varghese , J , Soares , R F & Sapkota , G P 2023 , ' An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation ' , Cell Chemical Biology , vol. 30 , no. 2 , pp. 188-202 . https://doi.org/10.1016/j.chembiol.2023.01.003Test

مصطلحات موضوعية: Affinity-directed phosphatase, AdPhosphatase, Targeted dephosphorylation, PPP1CA, PPP2CA, Nanobody, ULK1, FAM83D, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/b0ee5ed6-6d18-4e15-bd77-1c5b5ba96ccaTest

الإتاحة: https://doi.org/10.1016/j.chembiol.2023.01.003Test
https://discovery.dundee.ac.uk/en/publications/b0ee5ed6-6d18-4e15-bd77-1c5b5ba96ccaTest
https://discovery.dundee.ac.uk/ws/files/96764889/1_s2.0_S2451945623000260_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85148030514&partnerID=8YFLogxKTest

المؤلفون: Simpson, Luke M., Glennie, Lorraine, Brewer, Abigail, Zhao, Jin-Feng, Crooks, Jennifer, Shpiro, Natalia, Sapkota, Gopal P.

المصدر: Simpson , L M , Glennie , L , Brewer , A , Zhao , J-F , Crooks , J , Shpiro , N & Sapkota , G P 2022 , ' Target protein localization and its impact on PROTAC-mediated degradation ' , Cell Chemical Biology , vol. 29 , no. 10 , pp. 1482-1504.e7 . https://doi.org/10.1016/j.chembiol.2022.08.004Test

مصطلحات موضوعية: proteolysis-targeting chimera (PROTAC), Targeted protein degradation (TPD), protein localization, degrader, dTAG, Halo, VHL, cereblon, CRBN, E3, HiBiT, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/1b78f0bd-7662-418b-a4d9-33149454ca2aTest

الإتاحة: https://doi.org/10.1016/j.chembiol.2022.08.004Test
https://discovery.dundee.ac.uk/en/publications/1b78f0bd-7662-418b-a4d9-33149454ca2aTest
https://discovery.dundee.ac.uk/ws/files/80555670/PIIS2451945622003129.pdfTest
http://www.scopus.com/inward/record.url?scp=85140068494&partnerID=8YFLogxKTest

المؤلفون: Webb, Thomas, Craigon, Conner, Ciulli, Alessio

المصدر: Webb , T , Craigon , C & Ciulli , A 2022 , ' Targeting Epigenetic Modulators Using PROTAC Degraders : Current Status and Future Perspective ' , Bioorganic & Medicinal Chemistry Letters , vol. 63 , 128653 . https://doi.org/10.1016/j.bmcl.2022.128653Test

مصطلحات موضوعية: Chromatin, Degraders, Epigenetics, GNJIONZKYKHKNJ-UHFFFAOYSA-N, HDCCMCFIGHIDJR-TUDDPRDOSA-N, IJHBBPTVQYEAGQ-MSDWBBBCSA-N, ILVRLRGBSSFKIE-UHFFFAOYSA-N, IVARZBJJMMUJHI-SQKKEFIPSA-N, LONVYJSHGSZBQY-UHFFFAOYSA-N, Multiprotein complexes, PROTACs, Targeted protein degradation, Therapeutics, XQVSBRMMLVXWSD-UHFFFAOYSA-N, YABKDZZQDGCZTF-YUIXOWAOSA-N, ZAGCLFXBHOXXEN-JPTLTNPLSA-N, ZGCCNKFVHQHHRK-ZWHPVRQASA-N, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/1600/1605

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/a396bb08-21d7-4acd-92ad-b99077eb10fcTest

الإتاحة: https://doi.org/10.1016/j.bmcl.2022.128653Test
https://discovery.dundee.ac.uk/en/publications/a396bb08-21d7-4acd-92ad-b99077eb10fcTest
https://discovery.dundee.ac.uk/ws/files/73258206/1_s2.0_S0960894X22001299_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85125992464&partnerID=8YFLogxKTest

المؤلفون: Libardo, M. Daben J, Duncombe, Caroline J., Green, Simon R., Wyatt, Paul G., Thompson, Stephen, Ray, Peter C., Ioerger, Thomas R., Oh, Sangmi, Goodwin, Michael B., Boshoff, Helena I. M., Barry III, Clifton E.

المصدر: Libardo , M D J , Duncombe , C J , Green , S R , Wyatt , P G , Thompson , S , Ray , P C , Ioerger , T R , Oh , S , Goodwin , M B , Boshoff , H I M & Barry III , C E 2021 , ' Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis ' , Cell Chemical Biology , vol. 28 , no. 8 , pp. 1180-1191.e20 . https://doi.org/10.1016/j.chembiol.2021.02.023Test

مصطلحات موضوعية: tuberculosis, drug mechanism of action, pro-drug, tryptophan metabolism, antimetabolite, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/0a2339ec-4429-49c5-a052-1a47caae007dTest

الإتاحة: https://doi.org/10.1016/j.chembiol.2021.02.023Test
https://discovery.dundee.ac.uk/en/publications/0a2339ec-4429-49c5-a052-1a47caae007dTest
https://discovery.dundee.ac.uk/ws/files/57600215/1_s2.0_S2451945621001082_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85112587717&partnerID=8YFLogxKTest

المؤلفون: Soliman, Aiten M., Mekkawy, Mai H., Karam, Heba M., Higgins, Maureen, Dinkova-kostova, Albena T., Ghorab, Mostafa M.

المصدر: Soliman , A M , Mekkawy , M H , Karam , H M , Higgins , M , Dinkova-kostova , A T & Ghorab , M M 2021 , ' Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress ' , Bioorganic & Medicinal Chemistry Letters , vol. 42 , 128002 . https://doi.org/10.1016/j.bmcl.2021.128002Test

مصطلحات موضوعية: Docking, Iodinated quinazolinones, NQO1, ROS, Radioprotective activity, Sulfonamide, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/01d17057-a74c-4d77-95d0-3d676f2b2944Test

الإتاحة: https://doi.org/10.1016/j.bmcl.2021.128002Test
https://discovery.dundee.ac.uk/en/publications/01d17057-a74c-4d77-95d0-3d676f2b2944Test
https://discovery.dundee.ac.uk/ws/files/57721756/1_s2.0_S0960894X21002286_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85105357972&partnerID=8YFLogxKTest

المؤلفون: Roth, Sascha, Macartney, Thomas, Konopacka, Agnieszka, Chan, Kwok-Ho, Zhou, Houjiang, Queisser, Markus A., Sapkota, Gopal

المصدر: Roth , S , Macartney , T , Konopacka , A , Chan , K-H , Zhou , H , Queisser , M A & Sapkota , G 2020 , ' Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System ' , Cell Chemical Biology , vol. 27 , no. 9 , pp. 1151-1163.e6 . https://doi.org/10.1016/j.chembiol.2020.06.012Test

مصطلحات موضوعية: cancer targets, monobody, nanobody, oncogene, PROTAC, protein degradation, RAS, RAS/MAPK signaling, targeted proteolysis, ubiquitin proteasome system, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/885c077c-beba-4ed3-84bb-0ee8f06c4716Test

الإتاحة: https://doi.org/10.1016/j.chembiol.2020.06.012Test
https://discovery.dundee.ac.uk/en/publications/885c077c-beba-4ed3-84bb-0ee8f06c4716Test
https://discovery.dundee.ac.uk/ws/files/51970929/1_s2.0_S245194562030235X_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85089297813&partnerID=8YFLogxKTest

المؤلفون: Vanaerschot, Manu, Murithi, James M., Pasaje, Charisse Flerida A., Ghidelli-Disse, Sonja, Dwomoh, Louis, Bird, Megan, Spottiswoode, Natasha, Mittal, Nimisha, Arendse, Lauren B., Owen, Edward S., Wicht, Kathryn J., Siciliano, Giulia, Bösche, Markus, Yeo, Tomas, Kumar, T. R. Santha, Mok, Sachel, Carpenter, Emma F., Giddins, Marla J., Sanz, Olalla, Ottilie, Sabine, Alano, Pietro, Chibale, Kelly, Llinás, Manuel, Uhlemann, Anne Catrin, Delves, Michael, Tobin, Andrew B., Doerig, Christian, Winzeler, Elizabeth A., Lee, Marcus C.S., Niles, Jacquin C., Fidock, David A.

المصدر: Vanaerschot , M , Murithi , J M , Pasaje , C F A , Ghidelli-Disse , S , Dwomoh , L , Bird , M , Spottiswoode , N , Mittal , N , Arendse , L B , Owen , E S , Wicht , K J , Siciliano , G , Bösche , M , Yeo , T , Kumar , T R S , Mok , S , Carpenter , E F , Giddins , M J , Sanz , O , Ottilie , S , Alano , P , Chibale , K , Llinás ....

مصطلحات موضوعية: cGMP-dependent protein kinase (PKG), chemoproteomics, conditional knockdown, kinase, malaria drug discovery, phosphoproteomics, Plasmodium falciparum, resistance, target identification, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/bb93ec18-7d46-4312-8729-97d5c19cb502Test

الإتاحة: https://doi.org/10.1016/j.chembiol.2020.04.001Test
https://discovery.dundee.ac.uk/en/publications/bb93ec18-7d46-4312-8729-97d5c19cb502Test
https://discovery.dundee.ac.uk/ws/files/104657588/PIIS245194562030115X.pdfTest
http://www.scopus.com/inward/record.url?scp=85087768957&partnerID=8YFLogxKTest

المؤلفون: Murithi, James M., Owen, Edward S., Istvan, Eva S., Lee, Marcus C.S., Ottilie, Sabine, Chibale, Kelly, Goldberg, Daniel E., Winzeler, Elizabeth A., Llinás, Manuel, Fidock, David A., Vanaerschot, Manu

المصدر: Murithi , J M , Owen , E S , Istvan , E S , Lee , M C S , Ottilie , S , Chibale , K , Goldberg , D E , Winzeler , E A , Llinás , M , Fidock , D A & Vanaerschot , M 2020 , ' Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery ' , Cell Chemical Biology , vol. 27 , no. 2 , pp. 158-171.e3 . https://doi.org/10.1016/j.chembiol.2019.11.009Test

مصطلحات موضوعية: asexual blood stages, drug resistance, hemoglobin catabolism, malaria, metabolomics, mitochondria, mode of action, Plasmodium falciparum, target identification, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/814a9547-0493-45a2-b391-4596ae0e35faTest

الإتاحة: https://doi.org/10.1016/j.chembiol.2019.11.009Test
https://discovery.dundee.ac.uk/en/publications/814a9547-0493-45a2-b391-4596ae0e35faTest
https://discovery.dundee.ac.uk/ws/files/104721039/1_s2.0_S2451945619303915_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85079341308&partnerID=8YFLogxKTest

المؤلفون: Yoo, Euna, Schulze, Christopher J., Stokes, Barbara H., Onguka, Ouma, Yeo, Tomas, Mok, Sachel, Gnädig, Nina F., Zhou, Yani, Kurita, Kenji, Foe, Ian T., Terrell, Stephanie M., Boucher, Michael J., Cieplak, Piotr, Kumpornsin, Krittikorn, Lee, Marcus C.S., Linington, Roger G., Long, Jonathan Z., Uhlemann, Anne Catrin, Weerapana, Eranthie, Fidock, David A., Bogyo, Matthew

المصدر: Yoo , E , Schulze , C J , Stokes , B H , Onguka , O , Yeo , T , Mok , S , Gnädig , N F , Zhou , Y , Kurita , K , Foe , I T , Terrell , S M , Boucher , M J , Cieplak , P , Kumpornsin , K , Lee , M C S , Linington , R G , Long , J Z , Uhlemann , A C , Weerapana , E , Fidock , D A & Bogyo , M 2020 , ' The ....

مصطلحات موضوعية: activity-based probes, chemical proteomics, lipid metabolism, malaria, natural products, Plasmodium falciparum, Salinipostin A, serine hydrolases, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry

العلاقة: https://discovery.dundee.ac.uk/en/publications/b4bccaeb-9bca-48cc-a6ed-dedcc59ff89eTest

الإتاحة: https://doi.org/10.1016/j.chembiol.2020.01.001Test
https://discovery.dundee.ac.uk/en/publications/b4bccaeb-9bca-48cc-a6ed-dedcc59ff89eTest
http://www.scopus.com/inward/record.url?scp=85079357670&partnerID=8YFLogxKTest
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027986Test/