المؤلفون: Pranckeviciene, Alma, Vaitkeviciene, Inga, Siudikiene, Jolanta, Poskeviciene, Skaiste, Maciulskiene-Visockiene, Vita

المصدر: Medicina (Kaunas) ; ISSN:1648-9144 ; Volume:60 ; Issue:6

مصطلحات موضوعية: immediate implant placement, immediate implantation, periapical lesion, periapical pathology

الوصف: Background and Objectives: The present systematic review and meta-analysis were conducted to evaluate and compare the long-term clinical outcomes of immediate implants placed into fresh sockets with and without periapical pathology. Materials and Methods: After the search and review of the literature in the electronic databases, 109 publications were achieved. The titles and abstracts of 66 publications were screened. After the evaluation of the full text of 22 publications, based on the inclusion criteria, six controlled clinical studies were included in this systematic review and meta-analysis. Results: The statistical calculation showed no heterogeneity among the studies included. The implant survival was 99.6% in the test (socket with periapical pathology) and control (socket without periapical pathology) groups of all the clinical trials. The results of the meta-analysis showed no statistically significant difference between test and control groups regarding the marginal bone level and the width of keratinized mucosa in all the studies. Other parameters indicating plaque level, bleeding on probing, and gingival recession also did not differ between test and control groups at the final follow-up in nearly all studies. Conclusions: Within the limitation of this systemic review and meta-analysis, the obtained data suggest that implants immediately placed into the extraction sockets of teeth exhibiting periapical pathology can be successfully osseointegrated for an extended period.

العلاقة: https://doi.org/10.3390/medicina60060893Test; https://pubmed.ncbi.nlm.nih.gov/38929509Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206124Test/

الإتاحة: https://doi.org/10.3390/medicina60060893Test
https://pubmed.ncbi.nlm.nih.gov/38929509Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206124Test/

المؤلفون: Alvarez, Carla, Monasterio, Gustavo, Cavalla, Franco, Cordova, Luis A., Hernandez, Marcela, Heymann, Dominique, Garlet, Gustavo P., Sorsa, Timo, Pärnänen, Pirjo, Lee, Hsi-Ming, Golub, Lorne M., Vernal, Rolando, Kantarci, Alpdogan

المساهمون: HUS Head and Neck Center, Department of Oral and Maxillofacial Diseases, University Management, Timo Sorsa / Principal Investigator, University of Helsinki

مصطلحات موضوعية: osteoimmunology, oral, maxillofacial, periodontal disease, biomarkers, GINGIVAL CREVICULAR FLUID, ALVEOLAR BONE LOSS, PERIAPICAL LESION DEVELOPMENT, COLLAGEN-INDUCED ARTHRITIS, NECROSIS-FACTOR-ALPHA, REGULATORY T-CELLS, TEMPOROMANDIBULAR-JOINT, PORPHYROMONAS-GINGIVALIS, RHEUMATOID-ARTHRITIS, PROINFLAMMATORY CYTOKINES, 313 Dentistry

الوصف: The maxillofacial skeleton is highly dynamic and requires a constant equilibrium between the bone resorption and bone formation. The field of osteoimmunology explores the interactions between bone metabolism and the immune response, providing a context to study the complex cellular and molecular networks involved in oro-maxillofacial osteolytic diseases. In this review, we present a framework for understanding the potential mechanisms underlying the immuno-pathobiology in etiologically-diverse diseases that affect the oral and maxillofacial region and share bone destruction as their common clinical outcome. These otherwise different pathologies share similar inflammatory pathways mediated by central cellular players, such as macrophages, T and B cells, that promote the differentiation and activation of osteoclasts, ineffective or insufficient bone apposition by osteoblasts, and the continuous production of osteoclastogenic signals by immune and local stromal cells. We also present the potential translational applications of this knowledge based on the biological mechanisms involved in the inflammation-induced bone destruction. Such applications can be the development of immune-based therapies that promote bone healing/regeneration, the identification of host-derived inflammatory/collagenolytic biomarkers as diagnostics tools, the assessment of links between oral and systemic diseases; and the characterization of genetic polymorphisms in immune or bone-related genes that will help diagnosis of susceptible individuals. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: This work was financially supported by grants TYH 2016251, TYH 2017251, TYH 2018229, Y1014SL017, and Y1014SL018 from the Helsinki University Hospital Research Foundation, Finland; The Finnish Dental Association Apollonia; The Karolinska Institutet, Stockholm, Sweden; NIDCR grants R01 DE012872 and R01 DE25020 NIH; and grants FONDECYT 1140904, 1160741, and 1181780 from Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) from the Chilean Government. AK is supported by NIH grant AG062496.; Alvarez , C , Monasterio , G , Cavalla , F , Cordova , L A , Hernandez , M , Heymann , D , Garlet , G P , Sorsa , T , Pärnänen , P , Lee , H-M , Golub , L M , Vernal , R & Kantarci , A 2019 , ' Osteoimmunology of Oral and Maxillofacial Diseases : Translational Applications Based on Biological Mechanisms ' , Frontiers in Immunology , vol. 10 , 1664 . https://doi.org/10.3389/fimmu.2019.01664Test; b24705ca-8dfc-44b4-9b98-53b202022383; http://hdl.handle.net/10138/306028Test; 000475912600001

الإتاحة: http://hdl.handle.net/10138/306028Test

المؤلفون: Kalatzis-Sousa, N. G., Spin-Neto, R., Wenzel, A., Tanomaru-Filho, M., Faria, G.

المساهمون: Universidade Estadual Paulista (UNESP)

مصطلحات موضوعية: mice, micro-CT, periapical lesion, rats

الوصف: This systematic review aimed to evaluate the literature on the acquisition-, reconstruction- and analysis parameters of micro-computed tomography (micro-CT) for the assessment of periapical lesions in rats and mice, and to illustrate the effect of variation in these parameters. The PubMed database was searched from 2000 to January 2015 (English-language publications) for reports on the use of micro-CT to evaluate periapical lesions in rats and mice. QUADAS criteria were used to rate the quality of the studies. To illustrate the effect of variations in acquisition-, reconstruction-, and analysis parameters on images of periapical lesions, micro-CT examination of two hemi-mandibles of mice, with periapical lesions around the first molar was undertaken. Twenty-one studies were identified, which analysed periapical lesions in rats or mice using micro-CT. According to the QUADAS, no study was classified as high-, seven were classified as moderate-, and 14 as low quality. The effect of variation in parameters was that voxel size may interfere with image sharpness, reconstruction may interfere with image sharpness and contrast, and inadequate plane orientation may alter the size of the periapical lesion. Nonpersonalized ROIs resulted in areas that were not part of the periapical lesion. Changing the limits of the threshold for bone-tissue visualization increased lesion size. There is no defined protocol for acquiring and analysing micro-CT images of periapical lesions in rats and mice. Furthermore, acquisition-, reconstruction- and analysis parameters are not adequately explained, which may compromise the scientific impact of the studies.

وصف الملف: 352-366

العلاقة: International Endodontic Journal; 1,791; http://dx.doi.org/10.1111/iej.12633Test; International Endodontic Journal, v. 50, n. 4, p. 352-366, 2017.; http://hdl.handle.net/11449/172804Test; 2-s2.0-84962841377

الإتاحة: https://doi.org/10.1111/iej.12633Test
http://hdl.handle.net/11449/172804Test

المؤلفون: NAMDAR PEKİNER, FİLİZ MEDİHA, KESER, GAYE

المساهمون: Keser, Gaye, Pekiner, Filiz Namdar

مصطلحات موضوعية: Periapical lesion, radiology, panoramic radiography, cone beam computed tomography, BEAM COMPUTED-TOMOGRAPHY, ROOT-FILLED TEETH, ENDODONTICALLY TREATED TEETH, APICAL PERIODONTITIS, CORONAL RESTORATIONS, QUALITY, POPULATION, HEALTH, PREVALENCE, ADULT

الوصف: Periapical bone lesions are frequently seen in dentistry and may lead to tooth loss when not treated. Dental radiographic imaging is an important tool for making an accurate diagnosis and for performing clinical examinations in endodontic treatment. Panoramic and periapical radiographic techniques provide adequate information, yet these techniques provide a two-dimensional representation of three-dimensional structures. Recently, cone-beam computed tomography (CBCT) systems have become available for the three-dimensional visualization of the craniofacial complex and periapical bone lesions, and the evaluation of periapical bone lesions with CBCT improves the prognosis of the current treatment pathology and prevents possible bone destruction. This article presents periapical bone lesions and radiographic features.

العلاقة: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES; https://hdl.handle.net/11424/220224Test; WOS:000415887500006

الإتاحة: https://doi.org/10.5152/clinexphealthsci.2017.362Test
https://hdl.handle.net/11424/220224Test