مراجعة
Precision Medicine Approaches in Acute Myeloid Leukemia with Adverse Genetics.
| العنوان: | Precision Medicine Approaches in Acute Myeloid Leukemia with Adverse Genetics. |
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| المؤلفون: | Santoro, Nicole, Salutari, Prassede, Di Ianni, Mauro, Marra, Andrea |
| المصدر: | Int J Mol Sci ; ISSN:1422-0067 ; Volume:25 ; Issue:8 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | acute myeloid leukemia, adverse genetics, target-immunotherapy |
| الوصف: | The treatment of acute myeloid leukemia (AML) with adverse genetics remains unsatisfactory, with very low response rates to standard chemotherapy and shorter durations of remission commonly observed in these patients. The complex biology of AML with adverse genetics is continuously evolving. Herein, we discuss recent advances in the field focusing on the contribution of molecular drivers of leukemia biogenesis and evolution and on the alterations of the immune system that can be exploited with immune-based therapeutic strategies. We focus on the biological rationales for combining targeted therapy and immunotherapy, which are currently being investigated in ongoing trials, and could hopefully ameliorate the poor outcomes of patients affected by AML with adverse genetics. |
| نوع الوثيقة: | review article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/ijms25084259Test; https://pubmed.ncbi.nlm.nih.gov/38673842Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11050344Test/ |
| DOI: | 10.3390/ijms25084259 |
| الإتاحة: | https://doi.org/10.3390/ijms25084259Test https://pubmed.ncbi.nlm.nih.gov/38673842Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11050344Test/ |
| رقم الانضمام: | edsbas.ECC41F3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms25084259 |
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