مراجعة
MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance
| العنوان: | MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance |
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| المؤلفون: | Rauch, Nora, Rukhlenko, Oleksii S., Kolch, Walter, Kholodenko, Boris N. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | University College Dublin: Research Repository UCD |
| مصطلحات موضوعية: | MAPK, Cell fate decisions, Kinase signalling dynamic, Drug resistance, RAS/RAF/MEK, RAF dimerization, Drug therapies |
| الوصف: | The RAS/RAF/MEK/MAPK kinase pathway has been extensively studied for more than 25 years, yet we continue to be puzzled by its intricate dynamic control and plasticity. Different spatiotemporal MAPK dynamics bring about distinct cell fate decisions in normal vs cancer cells and developing organisms. Recent modelling and experimental studies provided novel insights in the versatile MAPK dynamics concerted by a plethora of feedforward/feedback regulations and crosstalk on multiple timescales. Multiple cancer types and various developmental disorders arise from persistent alterations of the MAPK dynamics caused by RAS/RAF/MEK mutations. While a key role of the MAPK pathway in multiple diseases made the development of novel RAF/MEK inhibitors a hot topic of drug development, these drugs have unexpected side-effects and resistance inevitably occurs. We review how RAF dimerization conveys drug resistance and recent breakthroughs to overcome this resistance. ; European Commission Horizon 2020 ; European Commission - Seventh Framework Programme (FP7) |
| نوع الوثيقة: | review |
| اللغة: | English |
| العلاقة: | Current Opinion in Structural Biology; http://hdl.handle.net/10197/9082Test; 41; 151; 158 |
| DOI: | 10.1016/j.sbi.2016.07.019 |
| الإتاحة: | https://doi.org/10.1016/j.sbi.2016.07.019Test http://hdl.handle.net/10197/9082Test |
| حقوق: | This is the author’s version of a work that was accepted for publication in Current Opinion in Structural Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Current Opinion in Structural Biology, Volume 41, 2016, Pages 151-158, https://doi.org/10.1016/j.sbi.2016.07.019Test |
| رقم الانضمام: | edsbas.C22FEDA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.sbi.2016.07.019 |
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