التفاصيل البيبلوغرافية
| العنوان: |
Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions |
| المؤلفون: |
Hermann-Kleiter, Natascha, Baier, Gottfried |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2014 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Autoimmune disease, Pro-inflammatory Th17 cells, Nuclear orphan receptors, Immune response balance and check, NR2F-orphan receptor family, NFAT, AP-1, RORγt, Transcriptional regulation |
| الوصف: |
Members of the evolutionarily conserved family of the chicken ovalbumin upstream promoter transcription factor NR2F/COUP-TF orphan receptors have been implicated in lymphocyte biology, ranging from activation to differentiation and elicitation of immune effector functions. In particular, a CD4 + T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro-inflammatory cytokines interleukin (Il) 2, interferon y (ifng) and consequently of T helper (Th)17 CD4 + T cell-mediated autoimmune disorders has been discovered. NR2F6 serves as an antigen receptor signaling threshold-regulated barrier against autoimmunity where NR2F6 is part of a negative feedback loop that limits inflammatory tissue damage induced by weakly immunogenic antigens such as self-antigens. Under such low affinity antigen receptor stimulation, NR2F6 appears as a prototypical repressor that functions to “lock out” harmful Th17 lineage effector transcription. Mechanistically, only sustained high affinity antigen receptor-induced protein kinase C (PKC)-mediated phosphorylation has been shown to inactivate NR2F6, thereby displacing pre-bound NR2F6 from the DNA and, subsequently, allowing for robust NFAT/AP-1- and RORγt-mediated cytokine transcription. The NR2F6 target gene repertoire thus identifies a general anti-inflammatory gatekeeper role for this orphan receptor. Investigating these signaling pathway(s) will enable a greater knowledge of the genetic, immune, and environmental mechanisms that lead to chronic inflammation and of certain autoimmune disorders in a given individual. |
| نوع الوثيقة: |
review |
| اللغة: |
English |
| العلاقة: |
http://www.biosignaling.com/content/12/1/38Test |
| الإتاحة: |
http://www.biosignaling.com/content/12/1/38Test |
| حقوق: |
Copyright 2014 Hermann-Kleiter and Baier; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.1A06F945 |
| قاعدة البيانات: |
BASE |
