مراجعة
The antiarrhythmic effect and clinical consequences of ischemic preconditioning
| العنوان: | The antiarrhythmic effect and clinical consequences of ischemic preconditioning |
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| المؤلفون: | Evrengül, Harun., Seleci, Deniz., Tanrıverdi, Halil., Kaftan, Asuman. |
| سنة النشر: | 2006 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Cardioprotection, calcium transport, cell death, coronary artery bypass surgery, bimakalim, Antiarrhythmic, Ischemic preconditioning, adenosine, adenosine A1 receptor agonist, adenosine receptor, adenosine triphosphate, bradykinin receptor, cromakalim, diazoxide, heat shock protein, nicorandil, pinacidil, potassium channel, prostaglandin receptor, protein kinase C, antiarrhythmic activity, heart arrhythmia, heart infarction size, heart muscle cell, Animals, heart muscle ischemia, heart muscle necrosis, heart protection, heart supraventricular arrhythmia, heart ventricle arrhythmia |
| الوصف: | Potentially hazardous short ischemic episodes increase the tolerance of myocardium to ischemia paradoxically. This condition decreases the infarct area markedly caused by a longer duration of coronary occlusion. This phenomenon is known as 'ischemic preconditioning' and its powerful cardioprotective effect has been shown in experimental and clinical studies. Ischemic preconditioning decreases cardiac mortality markedly by preventing the development of left ventricular dysfunction and ventricular and supraventricular arrhythmias after acute myocardial infarction. Ischemia-induced opening of ATP-sensitive potassium channels and synthesis of stress proteins via activation of adenosine, bradykinin and prostaglandin receptors seem to be the possible mechanisms. By understanding the underlying mechanisms of ischemic preconditioning, it may be possible to develop new pharmacologic agents that cause ischemic preconditioning with antiischemic and antiarrhythmic properties without causing myocardial ischemia. © 2006 Lippincott Williams ; Wilkins. |
| نوع الوثيقة: | review |
| اللغة: | English |
| تدمد: | 0954-6928 |
| العلاقة: | Coronary Artery Disease; DiÄŸer; https://hdl.handle.net/11499/4599Test; https://doi.org/10.1097/00019501-200605000-00013Test; 17; 283; 288; 2-s2.0-33748324460; WOS:000237903900013 |
| DOI: | 10.1097/00019501-200605000-00013 |
| الإتاحة: | https://doi.org/10.1097/00019501-200605000-00013Test https://hdl.handle.net/11499/4599Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.F23EEEE7 |
| قاعدة البيانات: | BASE |
| تدمد: | 09546928 |
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| DOI: | 10.1097/00019501-200605000-00013 |