دورية أكاديمية
Targeted Treatment of Non-Small Cell Lung Cancer: Focus on Capmatinib with Companion Diagnostics
| العنوان: | Targeted Treatment of Non-Small Cell Lung Cancer: Focus on Capmatinib with Companion Diagnostics |
|---|---|
| المؤلفون: | Guo,Matthew Z, Marrone,Kristen A, Spira,Alexander, Waterhouse,David M, Scott,Susan C |
| بيانات النشر: | Dove Press |
| سنة النشر: | 2021 |
| المجموعة: | Dove Medical Press |
| مصطلحات موضوعية: | OncoTargets and Therapy |
| الوصف: | Matthew Z Guo,1 Kristen A Marrone,1 Alexander Spira,1– 3 David M Waterhouse,3,4 Susan C Scott1 1Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; 2Virginia Cancer Specialists Research Institute, Fairfax, VA, USA; 3US Oncology, The Woodlands, TX, USA; 4Oncology Hematology Care, Cincinnati, OH, UsaCorrespondence: Susan C ScottJohns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, 201 N Broadway, Baltimore, MD, 21287, USATel +1410-955-8893Fax +1410-367-2194Email sscott89@jhmi.eduAbstract: MET dysregulation promoting tumorigenesis in non-small cell lung cancer (NSCLC) is associated with worse outcomes following chemotherapy as compared to non-driver mutated NSCLC and occurs either through mutations causing MET exon 14 skipping (METex14) or gene amplification and overexpression that result in enhanced receptor signaling. Capmatinib is the first FDA-approved targeted therapy for NSCLC with METex14 skipping mutations, approved in 2020. FoundationOne® CDx, a comprehensive genomic profiling test for solid tumors, was concurrently approved as a companion diagnostic for capmatinib use. The GEOMETRY mono-1 phase II trial of capmatinib monotherapy demonstrated an overall response rate (ORR) of 68% in treatment naïve (n=28) and 41% in pre-treated (n=69) METex14 skipping advanced NSCLC; in MET amplified advanced NSCLC (gene copy number ≥ 10) ORRs of 40% in treatment naïve and 29% in pre-treated disease was seen. This review outlines the clinical data supporting capmatinib approval in the treatment of NSCLC and FoundationOne® CDx approval as a companion diagnostic. We detail the practical clinical administration of capmatinib, including dosing and toxicity management, compare capmatinib to other approved and investigational MET-targeted therapies, discuss limitations of capmatinib, and highlight ongoing trials of capmatinib in combinatorial approaches.Keywords: capmatinib, MET exon 14 skipping, non-small cell lung cancer, ... |
| نوع الوثيقة: | article in journal/newspaper review |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | https://www.dovepress.com/targeted-treatment-of-non-small-cell-lung-cancer-focus-on-capmatinib-w-peer-reviewed-fulltext-article-OTTTest |
| الإتاحة: | https://doi.org/10.2147/OTT.S273357Test https://www.dovepress.com/targeted-treatment-of-non-small-cell-lung-cancer-focus-on-capmatinib-w-peer-reviewed-fulltext-article-OTTTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7F1426F2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |