مراجعة
Targeted Gene Delivery Therapies for Cervical Cancer
| العنوان: | Targeted Gene Delivery Therapies for Cervical Cancer |
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| المؤلفون: | Áyen, Ángela, Jiménez Martínez, Yaiza, Boulaiz, Houria |
| المساهمون: | Áyen,A Department of Dermatology, San Cecilio Universitary Hospital, Granada, Spain. Áyen,A, Boulaiz,H Department of Human Anatomy and Embryology, University of Granada, Granada, Spain. Jiménez Martínez,Y, Boulaiz,H Biopathology and Medicine Regenerative Institute (IBIMER), University of Granada, Granada, Spain. Jiménez Martínez,Y, Boulaiz,H Biosanitary Institute of Granada (ibs.GRANADA), SAS-Universidad de Granada, Granada, Spain. Boulaiz,H Excellence Research Unit “Modeling Nature” (MNat), University of Granada, Granada, Spain., This research was supported by the Fundación Mutua Madrileña (project FMM-AP16683-2017) and Consejería de Salud Junta de Andalucía (PI-0089-2017). |
| بيانات النشر: | MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Cervical cancer, Targeted gene therapy, Delivery systems, Immunopotentiation, Cervical cancer stem cells, Neoplasias del cuello uterino, Terapia genética, Técnicas de transferencia de gen, Sistema inmunológico, Células madre neoplásicas, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Uterine Cervical Neoplasms, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Genetic Therapy, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Transfer Techniques, Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System, Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Check Tags::Female, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Oncolytic Virotherapy, Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Nanotechnology, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunization::Immunotherapy, Active::Vaccination |
| الوصف: | Despite being largely preventable through early vaccination and screening strategies, cervical cancer is the most common type of gynecological malignancy worldwide and constitutes one of the leading causes of cancer deaths in women. Patients with advanced or recurrent disease have a very poor prognosis; hence, novel therapeutic modalities to improve clinical outcomes in cervical malignancy are needed. In this regard, targeted gene delivery therapy is presented as a promising approach, which leads to the development of multiple strategies focused on different aspects. These range from altered gene restoration, immune system potentiation, and oncolytic virotherapy to the use of nanotechnology and the design of improved and enhanced gene delivery systems, among others. In the present manuscript, we review the current progress made in targeted gene delivery therapy for cervical cancer, the advantages and drawbacks and their clinical application. At present, multiple targeted gene delivery systems have been reported with encouraging preclinical results. However, the translation to humans has not yet shown a significant clinical benefit due principally to the lack of efficient vectors. Real efforts are being made to develop new gene delivery systems, to improve tumor targeting and to minimize toxicity in normal tissues. ; Yes |
| نوع الوثيقة: | review |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| العلاقة: | https://www.mdpi.com/2072-6694/12/5/1301/htmTest; Áyen Á, Jiménez Martínez Y, Boulaiz H. Targeted Gene Delivery Therapies for Cervical Cancer. Cancers. 2020 May 21;12(5):1301; http://hdl.handle.net/10668/3729Test; PMC7281413 |
| DOI: | 10.3390/cancers12051301 |
| الإتاحة: | https://doi.org/10.3390/cancers12051301Test http://hdl.handle.net/10668/3729Test |
| حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.886FD38A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
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| DOI: | 10.3390/cancers12051301 |