دورية أكاديمية
Advances in the understanding and exploitation of carbohydrate-active enzymes.
| العنوان: | Advances in the understanding and exploitation of carbohydrate-active enzymes. |
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| المؤلفون: | Bains, Rajneesh K, Nasseri, Seyed Amirhossein, Wardman, Jacob F, Withers, Stephen G |
| المصدر: | Curr Opin Chem Biol ; ISSN:1879-0402 ; Volume:80 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Activity-based probes, Carbohydrate-active enzymes, Chemoenzymatic synthesis, Enzyme mechanisms, Glycans, Glycobiology, Glycoside hydrolases, Glycosyltransferases, Immunotherapy, Lytic polysaccharide monooxygenases, Microbiome |
| الوصف: | Carbohydrate-active enzymes (CAZymes) are responsible for the biosynthesis, modification and degradation of all glycans in Nature. Advances in genomic and metagenomic methodologies, in conjunction with lower cost gene synthesis, have provided access to a steady stream of new CAZymes with both well-established and novel mechanisms. At the same time, increasing access to cryo-EM has resulted in exciting new structures, particularly of transmembrane glycosyltransferases of various sorts. This improved understanding has resulted in widespread progress in applications of CAZymes across diverse fields, including therapeutics, organ transplantation, foods, and biofuels. Herein, we highlight a few of the many important advances that have recently been made in the understanding and applications of CAZymes. |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.cbpa.2024.102457Test; https://pubmed.ncbi.nlm.nih.gov/38657391Test |
| DOI: | 10.1016/j.cbpa.2024.102457 |
| الإتاحة: | https://doi.org/10.1016/j.cbpa.2024.102457Test https://pubmed.ncbi.nlm.nih.gov/38657391Test |
| حقوق: | Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved. |
| رقم الانضمام: | edsbas.DB9C45D2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cbpa.2024.102457 |
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