مراجعة
The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach
| العنوان: | The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach |
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| المؤلفون: | Ríos-Tamayo, Rafael, Puig, Noemí, Algarín, Macarena, García de Veas Silva, José Luís, Barbosa, Nuno, Encinas, Cristina, Hernández, José Ángel, Alonso, Rafael, Campos, María Luisa, Rodríguez, Teresa, Leivas, Alberto, Olivares, María José, Sánchez, María José, Paiva, Bruno, Lahuerta, Juan José, Martínez-López, Joaquín |
| المساهمون: | Ríos-Tamayo,R Hematology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain. Ríos-Tamayo,R, Sánchez,MJ Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain. Ríos-Tamayo,R, Sánchez,MJ Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Puig,N Hematology Department, Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC) CIBERONC, Salamanca, Spain. Algarín,M, Barbosa,N, Campos,ML, Leivas,A Scientific Department, The Binding Site Iberia, Barcelona, Spain. García de Veas Silva,JL Molecular Diagnosis Laboratory Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain. Encinas,C Hematology Department, Hospital General Universitario Gregorio Marañón, IiGM, Madrid, Spain. Hernández,JÁ Hematology Department, Hospital Universitario Infanta Leonor, Madrid, Spain. Alonso,R, Martínez-López,J Hematology Department, Hospital Universitario 12 de Octubre, Madrid, Spain. Rodríguez,T, Olivares,MJ Immunology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain. Sánchez,MJ Registro de Cáncer de Granada, Escuela Andaluza de Salud Pública (EASP), Granada, Spain. Sánchez,MJ Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain. Paiva,B Clínica Universidad de Navarra, CIMA, CIBERONC, IDISNA, Pamplona, Spain. Lahuerta,JJ, Martínez-López,J Instituto de Investigación del Hospital Universitario 12 de Octubre, Madrid, Spain. |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Multiple myeloma, Heavy/light chain assay, Hevylite, Diagnosis, Prognosis, Monitoring, Mieloma múltiple, Cadenas pesadas de inmunoglobulina, Cadenas ligeras de inmunoglobulina, Inmunoensayo, Procesamiento automatizado de datos, Diagnóstico, Pronóstico, Monitorización del ambiente, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell::Multiple Myeloma, Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Blood Protein Disorders::Paraproteinemias, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Immunoglobulin Subunits::Immunoglobulin Light Chains, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis, Plasma Cell |
| الوصف: | Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care process. Conventional laboratory methods have been and continue to be the basis of laboratory testing in monoclonal gammopathies, along with the serum free light chain test. However, more accurate methods are needed to achieve new and more stringent clinical goals. The heavy/light chain assay is a relatively new test which can overcome some of the limitations of the conventional methods for the evaluation of intact immunoglobulin MM patients. Here, we report an update of the evidence accumulated in recent years on this method regarding its use in MM. ; Yes |
| نوع الوثيقة: | review |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2075-4418 |
| العلاقة: | https://www.mdpi.com/2075-4418/11/11/2020/htmTest; Ríos-Tamayo R, Puig N, Algarín M, García de Veas Silva JL, Barbosa N, Encinas C, et al. The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach. Diagnostics. 2021 Oct 30;11(11):2020; http://hdl.handle.net/10668/4422Test; PMC8620453 |
| DOI: | 10.3390/diagnostics11112020 |
| الإتاحة: | https://doi.org/10.3390/diagnostics11112020Test http://hdl.handle.net/10668/4422Test |
| حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.802C8CE2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20754418 |
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| DOI: | 10.3390/diagnostics11112020 |