دورية أكاديمية
Cytotoxic compounds derived from marine sponges. A Review (2010-2012)
| العنوان: | Cytotoxic compounds derived from marine sponges. A Review (2010-2012) |
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| المؤلفون: | Mioso, Roberto, Toledo-Marante, Francisco J., De Souza Bezerra, Ranilson, Pereira Borges, Flavio Valadares, De Oliveira Santos, Barbara V., Herrera Bravo de Laguna, Irma |
| المساهمون: | 55535031500, 56196675400, 7003699879, 57190220882, 7006476949, 14069914200, 2546418, 1695766, 19819062, 7891366, 6854191, 3019866, WOS:Mioso, R, WOS:Marante, FJT, WOS:Bezerra, RD, WOS:Borges, FVP, WOS:Santos, BVD, WOS:de Laguna, IHB |
| المصدر: | Molecules,v. 22 (208) |
| سنة النشر: | 2017 |
| المجموعة: | Universidad de Las Palmas de Gran Canaria: Acceda |
| مصطلحات موضوعية: | 2401 Biología animal (zoología), 3209 Farmacología, Porifera, Marine sponges, Pharmacology, Bioactive molecules, Cytotoxicity, Cancer cell lines |
| الوصف: | This extensive review covers research published between 2010 and 2012 regarding new compounds derived from marine sponges, including 62 species from 60 genera belonging to 33 families and 13 orders of the Demospongia class (Porifera). The emphasis is on the cytotoxic activity that bioactive metabolites from sponges may have on cancer cell lines. At least 197 novel chemical structures from 337 compounds isolated have been found to support this work. Details on the source and taxonomy of the sponges, their geographical occurrence, and a range of chemical structures are presented. The compounds discovered from the reviewed marine sponges fall into mainly four chemical classes: terpenoids (41.9%), alkaloids (26.2%), macrolides (8.9%) and peptides (6.3%) which, along with polyketides, sterols, and others show a range of biological activities. The key sponge orders studied in the reviewed research were Dictyoceratida, Haplosclerida, Tetractinellida, Poecilosclerida, and Agelasida. Petrosia, Haliclona (Haplosclerida), Rhabdastrella (Tetractinellida), Coscinoderma and Hyppospongia (Dictyioceratida), were found to be the most promising genera because of their capacity for producing new bioactive compounds. Several of the new compounds and their synthetic analogues have shown in vitro cytotoxic and pro-apoptotic activities against various tumor/cancer cell lines, and some of them will undergo further in vivo evaluation. ; 0,855 ; 3,098 ; Q1 ; Q2 ; SCIE |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| ردمك: | 978-85-01-40454-1 978-0-00-395552-1 85-01-40454-3 0-00-395552-4 |
| تدمد: | 1420-3049 |
| العلاقة: | Molecules; 22; http://hdl.handle.net/10553/37101Test; 85014045436; 000395552400022; Sí |
| DOI: | 10.3390/molecules22020208 |
| الإتاحة: | https://doi.org/10.3390/molecules22020208Test http://hdl.handle.net/10553/37101Test |
| رقم الانضمام: | edsbas.ED04419F |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9788501404541 9780003955521 8501404543 0003955524 |
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| تدمد: | 14203049 |
| DOI: | 10.3390/molecules22020208 |