المؤلفون: Bisgaard Jörgensen, Line, Bastholt, Lars, Yderstraede, Knud

المصدر: Ugeskrift for Laeger. 180(2):132

المؤلفون: Waeber, B., Ruilope, L.M.

المصدر: Vascular Health and Risk Management, vol. 5, no. 1, pp. 165-174

مصطلحات موضوعية: Age Factors, Aged, Amlodipine/adverse effects, Amlodipine/therapeutic use, Angiotensin II Type 1 Receptor Blockers/adverse effects, Angiotensin II Type 1 Receptor Blockers/therapeutic use, Antihypertensive Agents/therapeutic use, Blood Pressure/drug effects, Calcium Channel Blockers/adverse effects, Calcium Channel Blockers/therapeutic use, Diuretics/therapeutic use, Drug Combinations, Humans, Hypertension/drug therapy, Hypertension/physiopathology, Medication Adherence, Middle Aged, Tetrazoles/adverse effects, Tetrazoles/therapeutic use, Treatment Outcome

الوصف: Pharmacological treatment of hypertension is effective in preventing cardiovascular and renal complications. Calcium antagonists and blockers of the renin-angiotensin system are widely used today to initiate antihypertensive therapy but, when given as monotherapy, do not suffice in most patients to normalize blood pressure. Combining the two types of agents considerably increases the antihypertensive efficacy, but not at the expense of a deterioration of tolerability. This is exemplified by the experience accumulated with the recently developed fixed dose combination containing the AT(1)-receptor blocker valsartan (160 mg) and the dihydropyridine amlodipine (5 or 10 mg). In a randomized trial, an 8-week treatment normalized blood pressure (<140/90 mmHg) within 8 weeks in a large fraction of hypertensive patients (78.4% and 85.2% using the 5/160 [n = 371] and 10/160 mg [n = 377] dosage, respectively). Like all AT(1)-receptor blockers valsartan has a placebo-like tolerability. Valsartan prevents to a large extent the occurrence amlodipine-induced peripheral edema. Both amlodipine and valsartan have beneficial effects on cardiovascular morbidity and mortality, as well as protective effects on renal function. The co-administration of these two agents is therefore very attractive, as it enables a rapid and sustained blood pressure control in hypertensive patients. The availability of a fixed-dose combination based on amlodipine and valsartan is expected therefore to facilitate the management of hypertension, to improve long-term adherence with antihypertensive therapy and, ultimately, to have a positive impact on cardiovascular and renal outcomes.

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/19436661; info:eu-repo/semantics/altIdentifier/pissn/1178-2048[electronic]; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_F0D25C6C63EC3; https://serval.unil.ch/notice/serval:BIB_F0D25C6C63ECTest; https://serval.unil.ch/resource/serval:BIB_F0D25C6C63EC.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F0D25C6C63EC3Test

الإتاحة: https://serval.unil.ch/notice/serval:BIB_F0D25C6C63ECTest
https://serval.unil.ch/resource/serval:BIB_F0D25C6C63EC.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F0D25C6C63EC3Test

المؤلفون: Löwhagen, G B

المصدر: Information från Läkemedelsverket. 16(4):59

المؤلفون: Biglarnia, Ali-Reza, Yamamoto, Shinji, Gustafsson, Bengt I, Berne, Christian, Wagner, Michael, Von Zur-Mühlen, Bengt, Tufveson, Gunnar

المصدر: Läkartidningen. 109(39-40):1754

المؤلفون: Aarönaes, M, Atar, D, Bonarjee, V, Gundersen, T, Löchen, M L, Mo, R, Myhre, E S, Omland, T, Rönnevik, P K, Vegsundsvåg, J, Westheim, A

المصدر: Tidsskrift for Den Norske Laegeforening. 127(2):174

المؤلفون: Liedholm, H, Björck Linne, A

المصدر: Läkartidningen. 103(18):1417

المؤلفون: Wändell, P E

المصدر: Scandinavian Journal of Primary Health Care. 23(2):68

المؤلفون: Hedbrant, J

المصدر: Tidskriften Medikament. 9(8):46

المؤلفون: Christiansen, E, Madsbad, S

المصدر: Ugeskrift for Laeger. 154(27):1886

المؤلفون: Erdine, S., Ari, O., Zanchetti, A., Cifkova, R., Fagard, R., Kjeldsen, S., Mancia, G., Poulter, N., Rahn, K.H., Rodicio, J.L., Ruilope, L.M., Staessen, J., van Zwieten, P., Waeber, B., Williams, B.

المصدر: Herz, vol. 31, no. 4, pp. 331-338

مصطلحات موضوعية: Age Factors, Aged, 80 and over, Antihypertensive Agents, Blood Pressure Determination, Blood Pressure Monitoring, Ambulatory, Cardiology, Diabetes Mellitus, Type 1, Type 2, Diabetic Nephropathies, Diastole, Diet, Drug Therapy, Combination, Dyslipidemias, Europe, Exercise, Female, Humans, Hypertension, Kidney Diseases, Life Style, Male, Middle Aged, Prognosis, Randomized Controlled Trials as Topic, Risk Assessment, Risk Factors

الوصف: The following is a brief statement of the 2003 European Society of Hypertension (ESH)-European Society of Cardiology (ESC) guidelines for the management of arterial hypertension.The continuous relationship between the level of blood pressure and cardiovascular risk makes the definition of hypertension arbitrary. Since risk factors cluster in hypertensive individuals, risk stratification should be made and decision about the management should not be based on blood pressure alone, but also according to the presence or absence of other risk factors, target organ damage, diabetes, and cardiovascular or renal damage, as well as on other aspects of the patient's personal, medical and social situation. Blood pressure values measured in the doctor's office or the clinic should commonly be used as reference. Ambulatory blood pressure monitoring may have clinical value, when considerable variability of office blood pressure is found over the same or different visits, high office blood pressure is measured in subjects otherwise at low global cardiovascular risk, there is marked discrepancy between blood pressure values measured in the office and at home, resistance to drug treatment is suspected, or research is involved. Secondary hypertension should always be investigated.The primary goal of treatment of patient with high blood pressure is to achieve the maximum reduction in long-term total risk of cardiovascular morbidity and mortality. This requires treatment of all the reversible factors identified, including smoking, dislipidemia, or diabetes, and the appropriate management of associated clinical conditions, as well as treatment of the raised blood pressure per se. On the basis of current evidence from trials, it can be recommended that blood pressure, both systolic and diastolic, be intensively lowered at least below 140/90 mmHg and to definitely lower values, if tolerated, in all hypertensive patients, and below 130/80 mmHg in diabetics.Lifestyle measures should be instituted whenever appropriate in all patients, ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/16810473; info:eu-repo/semantics/altIdentifier/pissn/0340-9937; https://serval.unil.ch/notice/serval:BIB_ED50208EE073Test

الإتاحة: https://doi.org/10.1007/s00059-006-2829-3Test
https://serval.unil.ch/notice/serval:BIB_ED50208EE073Test