مراجعة
Meta-analysis: diagnostic accuracy of hepatitis C core antigen detection during therapy with direct-acting antivirals
| العنوان: | Meta-analysis: diagnostic accuracy of hepatitis C core antigen detection during therapy with direct-acting antivirals |
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| المؤلفون: | Sepulveda-Crespo, Daniel, Treviño-Nakoura, Ana, Bellon, José M, Ardizone Jimenez, Beatriz, Jimenez-Sousa, Maria Angeles, Fernandez-Rodriguez, Amanda, Martinez, Isidoro, Resino, Salvador |
| المساهمون: | Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Unión Europea. Comisión Europea. NextGenerationEU, Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | HCV, Direct-acting antivirals, HCV core antigen, Diagnostic performance, Therapy monitoring, Hepatitis C, Chronic, Antiviral Agents, Hepacivirus, Hepatitis C Antigens, Humans, RNA, Viral |
| الوصف: | Background: Treatment of hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) is monitored by assessing plasma HCV-RNA load. However, detection of HCV core antigen (HCVcAg) may be an alternative. Aim: To evaluate the diagnostic performance of the HCVcAg assay to monitor the efficacy of DAAs in HCV-infected patients METHODS: We performed searches in multiple electronic databases until 6 July 2022, of studies evaluating the HCVcAg detection in plasma or serum compared with the HCV-RNA test (gold standard). We calculated pooled measurement at 2 and 4 weeks of treatment, and at end-of-treatment (EOT), as well as sustained virological response (SVR; 12 weeks after EOT). Results: We selected 16 studies from 2016 to 2022, with 3237 patients and 8958 samples. Overall, the diagnostic performance and clinical utility of the HCVcAg assay were poor at week 2 (sensitivity = 0.40, specificity = 0.96, positive likelihood ratio (PLR) = 9.16, negative likelihood ratio (NLR) = 0.63, and area under the summary receiver operating curve (SROC) = 0.57), fair at week 4 (sensitivity = 0.30, specificity = 0.90, PLR = 3.18, NLR = 0.77, and AUC = 0.79), acceptable at EOT (sensitivity = 0.40, specificity =0.98, PLR = 16.54, NLR = 0.62, and AUC = 0.97) and excellent for SVR (sensitivity = 0.94, specificity = 0.99, PLR = 107.54, NLR = 0.06, and AUC = 0.99). Conclusions: The HCVcAg assay may be helpful for monitoring the efficacy of HCV treatment with DAAs in HCV-infected patients at EOT and for documenting SVR, but not at weeks 2 and 4 of treatment due to poor diagnostic performance. ; This study was supported by grants from Instituto de Salud Carlos III (ISCII; grant numbers PI20CIII/00004 to SR, and PI19CIII/00009 and PI22CIII/00019 to IM). This research was also supported by CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU (CB21/13/00044). DS-C is a ‘Sara Borrell’ researcher from ISCIII (grant nº ... |
| نوع الوثيقة: | review |
| اللغة: | English |
| تدمد: | 36031747 1365-2036 |
| العلاقة: | https://doi.org/10.1111/apt.17198Test; info:fis/Instituto de Salud Carlos III/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/Subprograma Estatal de Generación de Conocimiento/PI20-ISCIII Modalidad Proyectos de Investigacion en Salud Intramurales. (2020)/PI20CIII/00004; info:eu-repo/grantAgreement/ES/PI22CIII/00019; info:eu-repo/grantAgreement/ES/CB21/13/00044; info:eu-repo/grantAgreement/ES/CD20CIII/00001; Aliment Pharmacol Ther. 2022 Oct;56(8):1224-1234.; http://hdl.handle.net/20.500.12105/17185Test; Alimentary pharmacology & therapeutics |
| DOI: | 10.1111/apt.17198 |
| الإتاحة: | https://doi.org/20.500.12105/17185Test https://doi.org/10.1111/apt.17198Test https://hdl.handle.net/20.500.12105/17185Test |
| حقوق: | http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.2181E3E0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 36031747 13652036 |
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| DOI: | 10.1111/apt.17198 |