مراجعة
Diagnostic performance of hepatitis C core antigen assay to identify active infections: A systematic review and meta-analysis
| العنوان: | Diagnostic performance of hepatitis C core antigen assay to identify active infections: A systematic review and meta-analysis |
|---|---|
| المؤلفون: | Sepulveda-Crespo, Daniel, Treviño-Nakoura, Ana, Bellón, José M, Fernandez-Rodriguez, Amanda, Ryan, Pablo, Martinez, Isidoro, Jimenez-Sousa, Maria Angeles, Resino, Salvador |
| المساهمون: | Instituto de Salud Carlos III, Gilead Sciences (Spain), Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), Ministerio de Ciencia e Innovación (España), Unión Europea. Comisión Europea. NextGenerationEU |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Chronic hepatitis C, Diagnostic performance, HCV core antigen, HCV screening, HCVcAg, Hepatitis C Antigens, Hepatitis C, Humans, Sensitivity and Specificity, Prospective Studies, RNA, Viral, Hepacivirus |
| الوصف: | Objectives: Hepatitis C virus (HCV) core antigen (HCVcAg) assay is an alternative for diagnosing HCV infection in a single step. This meta-analysis aimed to evaluate the Abbott ARCHITECT HCV Ag assay's diagnostic performance (validity and utility) for diagnosing active hepatitis C. Methods: PubMed, EMBASE, Scopus, Web of Science, and Cochrane Library were searched until Jan 10, 2023. The protocol was registered at the prospective international register of systematic reviews (PROSPERO: CRD42022337191). Abbott ARCHITECT HCV Ag assay was the test for evaluation, and nucleic acid amplification tests with a cut-off ≤50 IU/mL were the gold standard. Statistical analysis was performed using STATA with the MIDAS module and random-effects models. Results: The bivariate analysis was conducted on 46 studies (18,116 samples). The pooled sensitivity was 0.96 (95%CI=0.94-0.97), specificity 0.99 (95%CI=0.99-1.00), positive likelihood ratio 141.81 (95%CI=72.39-277.79), and negative likelihood ratio 0.04 (95%CI=0.03-0.06). The area under the SROC curve was 1.00 (95%CI= 0.34-1.00). For active hepatitis C prevalence values of 0.1-15%, the probability that a positive test was a true positive was 12-96%, respectively, indicating that a confirmatory test should be necessary, particularly with a prevalence ≤5%. However, the probability that a negative test was a false negative was close to zero, indicating the absence of HCV infection. Conclusions: The validity (accuracy) of the Abbott ARCHITECT HCV Ag assay for screening active HCV infection in serum/plasma samples was excellent. Although the HCVcAg assay showed limited diagnostic utility in low prevalence settings (≤1%), it might help diagnose hepatitis C in high prevalence scenarios (≥5%). ; This study was supported by grants from Instituto de Salud Carlos III (ISCII; grant# PI20CIII/00004 to SR, and PI19CIII/00009 to IM) and Gilead Science(grant# GLD20_0144 to SR). This research was also supported by CIBER‐Consorcio Centrode Investigación Biomédica en Red (CB 2021), Instituto de ... |
| نوع الوثيقة: | review |
| اللغة: | English |
| تدمد: | 1099-1654 |
| العلاقة: | https://doi.org/10.1002/rmv.2436Test; info:fis/Instituto de Salud Carlos III/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/Subprograma Estatal de Generación de Conocimiento/PI20-ISCIII Modalidad Proyectos de Investigacion en Salud Intramurales. (2020)/PI20CIII/00004; info:fis/Instituto de Salud Carlos III/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/Subprograma Estatal de Generación de Conocimiento/PI19-ISCIII Modalidad Proyectos de Investigacion en Salud Intramurales. (2019)/PI19CIII/00009; info:eu-repo/grantAgreement/ES/CB21/13/00044; info:eu-repo/grantAgreement/ESCD20CIII/00001; Rev Med Virol. 2023 May;33(3):e2436.; http://hdl.handle.net/20.500.12105/17188Test; Reviews in medical virology |
| DOI: | 10.1002/rmv.2436 |
| الإتاحة: | https://doi.org/20.500.12105/17188Test https://doi.org/10.1002/rmv.2436Test https://hdl.handle.net/20.500.12105/17188Test |
| حقوق: | http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.5F309F5D |
| قاعدة البيانات: | BASE |
| تدمد: | 10991654 |
|---|---|
| DOI: | 10.1002/rmv.2436 |