التفاصيل البيبلوغرافية
| العنوان: |
Osteoimmunology of Oral and Maxillofacial Diseases : Translational Applications Based on Biological Mechanisms |
| المؤلفون: |
Alvarez, Carla, Monasterio, Gustavo, Cavalla, Franco, Cordova, Luis A., Hernandez, Marcela, Heymann, Dominique, Garlet, Gustavo P., Sorsa, Timo, Pärnänen, Pirjo, Lee, Hsi-Ming, Golub, Lorne M., Vernal, Rolando, Kantarci, Alpdogan |
| المساهمون: |
HUS Head and Neck Center, Department of Oral and Maxillofacial Diseases, University Management, Timo Sorsa / Principal Investigator, University of Helsinki |
| بيانات النشر: |
Frontiers Media |
| سنة النشر: |
2019 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
osteoimmunology, oral, maxillofacial, periodontal disease, biomarkers, GINGIVAL CREVICULAR FLUID, ALVEOLAR BONE LOSS, PERIAPICAL LESION DEVELOPMENT, COLLAGEN-INDUCED ARTHRITIS, NECROSIS-FACTOR-ALPHA, REGULATORY T-CELLS, TEMPOROMANDIBULAR-JOINT, PORPHYROMONAS-GINGIVALIS, RHEUMATOID-ARTHRITIS, PROINFLAMMATORY CYTOKINES, 313 Dentistry |
| الوصف: |
The maxillofacial skeleton is highly dynamic and requires a constant equilibrium between the bone resorption and bone formation. The field of osteoimmunology explores the interactions between bone metabolism and the immune response, providing a context to study the complex cellular and molecular networks involved in oro-maxillofacial osteolytic diseases. In this review, we present a framework for understanding the potential mechanisms underlying the immuno-pathobiology in etiologically-diverse diseases that affect the oral and maxillofacial region and share bone destruction as their common clinical outcome. These otherwise different pathologies share similar inflammatory pathways mediated by central cellular players, such as macrophages, T and B cells, that promote the differentiation and activation of osteoclasts, ineffective or insufficient bone apposition by osteoblasts, and the continuous production of osteoclastogenic signals by immune and local stromal cells. We also present the potential translational applications of this knowledge based on the biological mechanisms involved in the inflammation-induced bone destruction. Such applications can be the development of immune-based therapies that promote bone healing/regeneration, the identification of host-derived inflammatory/collagenolytic biomarkers as diagnostics tools, the assessment of links between oral and systemic diseases; and the characterization of genetic polymorphisms in immune or bone-related genes that will help diagnosis of susceptible individuals. ; Peer reviewed |
| نوع الوثيقة: |
review |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
This work was financially supported by grants TYH 2016251, TYH 2017251, TYH 2018229, Y1014SL017, and Y1014SL018 from the Helsinki University Hospital Research Foundation, Finland; The Finnish Dental Association Apollonia; The Karolinska Institutet, Stockholm, Sweden; NIDCR grants R01 DE012872 and R01 DE25020 NIH; and grants FONDECYT 1140904, 1160741, and 1181780 from Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) from the Chilean Government. AK is supported by NIH grant AG062496.; Alvarez , C , Monasterio , G , Cavalla , F , Cordova , L A , Hernandez , M , Heymann , D , Garlet , G P , Sorsa , T , Pärnänen , P , Lee , H-M , Golub , L M , Vernal , R & Kantarci , A 2019 , ' Osteoimmunology of Oral and Maxillofacial Diseases : Translational Applications Based on Biological Mechanisms ' , Frontiers in Immunology , vol. 10 , 1664 . https://doi.org/10.3389/fimmu.2019.01664Test; b24705ca-8dfc-44b4-9b98-53b202022383; http://hdl.handle.net/10138/306028Test; 000475912600001 |
| الإتاحة: |
http://hdl.handle.net/10138/306028Test |
| حقوق: |
cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.F5FA6A6F |
| قاعدة البيانات: |
BASE |
