مراجعة
Interlinked destinies: How ubiquitin-proteasome and autophagy systems underpin neurocognitive outcomes.
| العنوان: | Interlinked destinies: How ubiquitin-proteasome and autophagy systems underpin neurocognitive outcomes. |
|---|---|
| المؤلفون: | Yang, Xin, Duckhorn, Julia, Marshall, John, Huang, Yu-Wen Alvin |
| المصدر: | Exp Neurol ; ISSN:1090-2430 ; Volume:379 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Angelman syndrome, Autophagy, E3 ubiquitin ligase, Synaptic function, Ubiquitin-proteasome system (UPS), Ubiquitin-protein ligase E3A (UBE3A) |
| الوصف: | The protein homeostasis, or proteostasis, is maintained through the coupling of two pivotal systems: the ubiquitin-proteasome and autophagy. Cumulative evidence has suggested E3 ubiquitin ligases specifically play a central role in this coupling, ensuring the regulation of synaptic and cognitive functions. Defects in these ligases have been identified as hallmarks in a range of neurodevelopmental and neurodegenerative disorders. Recent literature has spotlighted the E3 ubiquitin ligase, UBE3A, as a key player in this domain. Dysregulation or loss of UBE3A function has been linked to disrupted proteostasis, leading to synaptic and cognitive anomalies. Notably, such defects are prominently observed in conditions like Angelman syndrome, a neurodevelopmental disorder characterized by severe cognitive impairments. The emerging understanding of UBE3A's role in bridging the ubiquitin-proteasome and autophagy systems offers a promising therapeutic avenue. Targeting the defective pathways caused by UBE3A loss could pave the way for innovative treatments, potentially ameliorating the cognitive deficits observed in neurological disorders like Angelman syndrome. As the scientific community delves deeper into the molecular intricacies of E3 ubiquitin ligases, there is burgeoning hope for devising effective interventions for associated neurological conditions. |
| نوع الوثيقة: | review article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.expneurol.2024.114869Test; https://pubmed.ncbi.nlm.nih.gov/38901755Test |
| DOI: | 10.1016/j.expneurol.2024.114869 |
| الإتاحة: | https://doi.org/10.1016/j.expneurol.2024.114869Test https://pubmed.ncbi.nlm.nih.gov/38901755Test |
| حقوق: | Copyright © 2024 Elsevier Inc. All rights reserved. |
| رقم الانضمام: | edsbas.6B900462 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.expneurol.2024.114869 |
|---|