تقرير
Osteoblast Transcriptome in 4 days old zebrafish larvae and the role of Fbln1 and Col10a1a bone extracellular matrix proteins during skeletal development
| العنوان: | Osteoblast Transcriptome in 4 days old zebrafish larvae and the role of Fbln1 and Col10a1a bone extracellular matrix proteins during skeletal development |
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| المؤلفون: | Raman, Ratish, Salomao D’Cruz Alison, Dikoum Cyrille, Zappia, Jérémie, Anthony Mishal, Caetano da Silva Caroline, Nivelle, Renaud, Lavergne, Arnaud, Degueldre Christian, Ostertag Agnes, Bahri, Mohamed Ali, Renn, Jörg, Collet Corrine, Plenevaux, Alain, Solal Cohen Martine, Henrotin, Yves, Muller, Marc |
| المساهمون: | GIGA I3-Laboratory for Organogenesis and Regeneration -ULiège, GIGA Platform Genomics, GIGA Platform Zebrafish Facility & Transgenics - ULiège, GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège, INSERM U1132 Bioscar and Universite de Paris Cite, Reference Centre for Rare Bone Diseases, Hospital Lariboisiere, F-75010, Paris, France |
| المصدر: | German Society for Matrix biology (Deutsche Gesellschaft fuer Matrixbiologie e.V.) DGMB 2022, Frankfurt am Main, Germany [DE], 07/09/2022 |
| سنة النشر: | 2022 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | osteoblasts, osetoblast transcriptome, zebrafish skeletal development, osteoarthritis, mineralization, tissue mineral density, bone extracellular matrix proteins, ECM, zebrafish, danio rerio, osteoblast population, hypertrophic chondrocytes, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire |
| الوصف: | Understanding osteoblast differentiation and their function in bone matrix deposition and mineralization is central to the comprehension of bone development and of various bone pathologies. It is, therefore, crucial to not only follow the expression of some landmark transcription factors or ECM proteins, but to also investigate the status of signaling pathways and factors regulating these processes. This can only be achieved by assessing the entire transcriptome of these cells. The aim is to study the osteoblast transcriptome, focusing on the possible existence of specific subpopulations at 4dpf and to investigate the role of efemp1, fbln1 and col10a1a genes that encode bone ECM proteins in zebrafish skeletal development indicated in the osteoblast transcriptomic data. |
| نوع الوثيقة: | report lecture |
| اللغة: | English |
| العلاقة: | info:eu-repo/grantAgreement/EC/H2020/766347; https://orbi.uliege.be/handle/2268/294661Test; info:hdl:2268/294661 |
| الإتاحة: | https://orbi.uliege.be/handle/2268/294661Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.4AE76908 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |