تقرير
Effect of adiponectin level and genetic variation of its receptors on diabetic retinopathy: A case–control study
| العنوان: | Effect of adiponectin level and genetic variation of its receptors on diabetic retinopathy: A case–control study |
|---|---|
| المؤلفون: | Wen-Ling Liao, Yung-Hsiang Chen, Ching-Chu Chen, Yu-Chuen Huang, Hui-Ju Lin, Yng-Tay Chen, Bo Ban, Chia-Ming Wu, Ya-Wen Chang, Ai-Ru Hsieh* and Fuu-Jen Tsai* |
| سنة النشر: | 2019 |
| المجموعة: | Tamkang University Institutional Repository (TKUIR) / 淡江大學機構典藏 |
| مصطلحات موضوعية: | CDH13, diabetic retinopathy, genetic variants, plasma adiponectin |
| الوصف: | Adiponectin (APN) and its receptors have been reported to be associated with metabolic phenotypes. To better understand the effects of APN levels and its receptors on diabetic retinopathy (DR), we investigated the association of the plasma APN level and variations in APN-related genes with DR, individually and in combination. Patients with type 2 diabetes (T2D; N = 1604), above 20 years of age from the Taiwanese population participated in the study. Demographic information, blood pressure, and serological markers were recorded at enrollment. Genomic DNA was isolated and genotyped. The plasma APN levels were measured by enzyme-linked immunosorbent assay. T2D patients with DR (N = 632) had diabetes for a longer duration, and had higher HbA1c, and systolic and diastolic blood pressure compared to those without DR (N = 972) (P < .001, for all the parameters). Overall, 10 single nucleotide polymorphisms (SNPs) in ADIPOQ and CDH13 susceptibility loci were associated with DR. Gene risk score (GRS) was calculated based on 10 SNPs for each subject and the cumulative effect of genes was observed. Among the subjects with plasma APN level (N = 518), natural logarithm (LN) of APN (LN [APN]; odds ratio [OR] = 1.63, 95% confidence interval [CI] = 1.19–2.25) and GRS (OR = 1.90, 95% CI = 1.11–3.26 for middle range of GRS, and OR = 2.61, 95% CI = 1.48–4.59 for high range of GRS) were independent risk factors for DR after adjustment for other parameters. In conclusion, the plasma APN level and the genetic variations in adiponectin receptors were associated with DR. ; 補正完畢 |
| نوع الوثيقة: | report |
| وصف الملف: | 109 bytes; text/html |
| اللغة: | Chinese |
| العلاقة: | Medicine (Baltimore) 98(11), p.14878; 全文連結 PDF已下載https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426570Test/; PMID: 30882695; http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/117107Test; http://tkuir.lib.tku.edu.tw:8080/dspace/bitstream/987654321/117107/1/index.htmlTest; http://tkuir.lib.tku.edu.tw:8080/dspace/bitstream/987654321/117107/-1/EffectTest of adiponectin level and genetic variation of its receptors on diabetic retinopathy A case–control study.pdf |
| الإتاحة: | http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/117107Test http://tkuir.lib.tku.edu.tw:8080/dspace/bitstream/987654321/117107/1/index.htmlTest http://tkuir.lib.tku.edu.tw:8080/dspace/bitstream/987654321/117107/-1/EffectTest of adiponectin level and genetic variation of its receptors on diabetic retinopathy A case–control study.pdf |
| رقم الانضمام: | edsbas.17DE36FC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |