تقرير
SARS-CoV-2 mechanistic correlates of protection: insight from modelling response to vaccines
| العنوان: | SARS-CoV-2 mechanistic correlates of protection: insight from modelling response to vaccines |
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| المؤلفون: | Alexandre, Marie, Marlin, Romain, Prague, MéLanie, Coleon, Séverin, Kahlaoui, Nidhal, Cardinaud, Sylvain, Naninck, Thibaut, Delache, Benoit, Surenaud, Mathieu, Galhaut, Mathilde, Dereuddre-Bosquet, Nathalie, Cavarelli, Mariangela, Maisonnasse, Pauline, Centlivre, Mireille, Lacabaratz, Christine, Wiedemann, Aurelie, Zurawski, Sandra, Zurawski, Gerard, schwartz, olivier, Sanders, Rogier, Le Grand, Roger, Levy, Yves, Thiébaut, Rodolphe |
| المساهمون: | Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Vaccine Research Institute (VRI), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Inserm, U955, Equipe 16, Créteil, France, Baylor Scott and White Research Institute and INSERM U955, Dallas, Texas, United States of America, Virus & Immunity Unit, Department of Virology, Institut Pasteur, Paris, France, CNRS UMR3569, Centre National de la Recherche Scientifique (CNRS), Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands, AP-HP, Hôpital Henri-Mondor Albert-Chenevier, Service d'Immunologie Clinique et Maladies Infectieuses 94000 Créteil, France |
| المصدر: | https://hal.archives-ouvertes.fr/hal-03482728Test ; 2021. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2021 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | SARS-CoV-2, Correlate of protection, Neutralization, Vaccines, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] |
| الوصف: | The definition of correlates of protection is critical for the development of next generation SARS-CoV-2 vaccine platforms. Here, we propose a new framework for identifying mechanistic correlates of protection based on mathematical modelling of viral dynamics and data mining of immunological markers. The application to three different studies in non-human primates evaluating SARS-CoV-2 vaccines based on CD40-targeting, two-component spike nanoparticle and mRNA 1273 identifies and quantifies two main mechanisms that are a decrease of rate of cell infection and an increase in clearance of infected cells. Inhibition of RBD binding to ACE2 appears to be a robust mechanistic correlate of protection across the three vaccine platforms although not capturing the whole biological vaccine effect. The model shows that RBD/ACE2 binding inhibition represents a strong mechanism of protection which required significant reduction in blocking potency to effectively compromise the control of viral replication. |
| نوع الوثيقة: | report |
| اللغة: | English |
| العلاقة: | hal-03482728; https://hal.archives-ouvertes.fr/hal-03482728Test; https://hal.archives-ouvertes.fr/hal-03482728/documentTest; https://hal.archives-ouvertes.fr/hal-03482728/file/20211024_Draft_mCoP_Medarxiv.pdfTest; BIORXIV: 2021.10.29.466418 |
| DOI: | 10.1101/2021.10.29.466418 |
| الإتاحة: | https://doi.org/10.1101/2021.10.29.466418Test https://hal.archives-ouvertes.fr/hal-03482728Test https://hal.archives-ouvertes.fr/hal-03482728/documentTest https://hal.archives-ouvertes.fr/hal-03482728/file/20211024_Draft_mCoP_Medarxiv.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.F8F69BA1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1101/2021.10.29.466418 |
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