التفاصيل البيبلوغرافية
| العنوان: |
Prognostic value of isocitrate dehydrogenase 1, O 6-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in Japanese malignant glioma patients |
| المؤلفون: |
Takahashi, Yoshinobu, Nakamura, Hideo, Makino, Keishi, Hide, Takuichiro, Muta, Daisuke, Kamada, Hajime, Kuratsu, Jun-ichi |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2013 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
IDH1, MGMT methylation, 1p19q co-deletion, Malignant glioma, Prognosis |
| الوصف: |
Background To determine the prognostic value of isocitrate dehydrogenase 1 ( IDH1 ) mutation, O 6 -methylguanine-DNA methyltransferase ( MGMT ) promoter methylation, and 1p/19q co-deletion in Japanese patients with malignant gliomas. Methods We studied 267 malignant gliomas, which included 171 glioblastomas (GBMs), 40 anaplastic astrocytomas (AAs), 30 anaplastic oligodendrogliomas (AOs), and 26 anaplastic oligoastrocytomas (AOAs). These malignant gliomas were divided into 2 groups (Group 1: GBM + AA, Group 2: AO + AOA) according to the presence of the oligodendroglioma component. We examined IDH1 mutation and MGMT promoter methylation in each group by direct sequencing and methylation-specific PCR, respectively. We further examined 1p/19q co-deletion in Group 2 by fluorescence in situ hybridization. Survival between groups was compared by Kaplan–Meier analysis. Results In Group 1, patients with IDH1 mutations exhibited a significantly longer survival time than patients with wild-type IDH1 . However, no significant difference was observed in Group 2, although patients with IDH1 mutations tended to show prolonged survival. For both Group 1 and Group 2, patients with MGMT methylation survived longer than those without this methylation. Further, patients with 1p/19q co-deletion showed significantly better outcome in Group 2. Conclusions Our study confirms the utility of IDH1 mutations and MGMT methylation in predicting the prognosis of Group 1 patients (GBM + AA) and demonstrated that IDH1 mutations may serve as a more reliable prognostic factor for such patients. We also showed that MGMT methylation and 1p/19q co-deletion rather than IDH1 mutations were prognostic factors for Group 2 patients (AOA + AO). Our study suggests that patients survive longer if they have IDH1 mutations and undergo total resection. Further, irrespective of MGMT promoter methylation status, the prognosis of glioma patients can be improved if total resection is performed. Moreover, our study includes the largest number of Japanese ... |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.wjso.com/content/11/1/284Test |
| الإتاحة: |
http://www.wjso.com/content/11/1/284Test |
| حقوق: |
Copyright 2013 Takahashi et al.; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.E7A41225 |
| قاعدة البيانات: |
BASE |
