التفاصيل البيبلوغرافية
| العنوان: |
Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration |
| المؤلفون: |
Hanene ELjebari, Nadia Ben Fradj, Issam Salouage, Emna Gaies, Sameh Trabelsi, Nadia Jebabli, Mohamed Lakhal, Tarek Ben Othman, Anis Kouz |
| بيانات النشر: |
Journal of Transplantation |
| سنة النشر: |
2012 |
| المجموعة: |
Hindawi Publishing Corporation |
| الوصف: |
Measurements of Cyclosporine (CsA) systemic exposure permit its dose adjustment in allogenic stem cell transplantation recipients to prevent graft-versus-host disease. CsA LSSs were developed and validated from 60 ASCT patients via multiple linear regressions. All whole-blood samples were analyzed by fluorescence polarization immunoassay (FPIA-Axym). The 10 models that have used CsA concentrations at a single time point did not have a good fit with AUC0–12 ( R 2 < 0 . 9 0 ). 𝐶 2 and 𝐶 4 were the time points that correlated best with AUC0–12 h, R 2 were respectively 0.848, and 0.897. The LSS equation with the best predictive performance (bias, precision and number of samples) utilized three sampling concentrations was AUC0–12 h = 0 . 6 0 7 + 1 . 5 6 9 × 𝐶 0 . 5 + 2 . 0 9 8 × 𝐶 2 + 3 . 6 0 3 × 𝐶 4 ( R 2 = 0 . 9 4 3 ) . Optimal LSSs equations which limited to those utilizing three timed concentrations taken within 4 hours post-dose developed from ASCT recipient's patients yielded a low bias <5% ranged from 1.27% to 2.68% and good precision <15% ranged from 9.60% and 11.02%. We propose an LSS model with equation AUC0–12 h = 0 . 8 2 + 2 . 7 6 6 × 𝐶 2 + 3 . 4 0 9 × 𝐶 4 for a practical reason. Bias and precision for this model are respectively 2.68% and 11.02%. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.1155/2012/342701Test |
| DOI: |
10.1155/2012/342701 |
| الإتاحة: |
https://doi.org/10.1155/2012/342701Test |
| حقوق: |
Copyright © 2012 Hanene ELjebari et al. |
| رقم الانضمام: |
edsbas.AA93612A |
| قاعدة البيانات: |
BASE |
