المؤلفون: Oda, Nao, Tamai, Koji, Suzuki, Yujiro, Yoshimatsu, Harukazu, Matsuoka, Hirofumi, Matsumoto, Yusuke, Okada, Nobuhiko

مصطلحات موضوعية: Autoimmune pulmonary alveolar proteinosis, Ambroxol, Severe hypoxemia

العلاقة: http://www.jmedicalcasereports.com/content/9/1/100Test

الإتاحة: http://www.jmedicalcasereports.com/content/9/1/100Test

المصدر: An Open-label, Multicenter Clinical Study to Evaluate the Efficacy and Safety of Inhaled Molgramostim in Pediatric Participants With Autoimmune Pulmonary Alveolar Proteinosis (aPAP).

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT06431776Test

المؤلفون: The First Affiliated Hospital of Guangzhou Medical University

المصدر: An Open-label Phase IIa Study to Evaluate the Safety and Preliminary Efficacy of hBMMSC Injection in the Treatment of aPAP

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT06111846Test

المصدر: A Randomized, Double-blind, Placebo-controlled Clinical Trial of Once-daily Inhaled Molgramostim Nebulizer Solution in Adult Subjects With Autoimmune Pulmonary Alveolar Proteinosis (aPAP)

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04544293Test

المؤلفون: Rare Diseases Clinical Research Network, National Heart, Lung, and Blood Institute (NHLBI)

المصدر: Trapnell BC, Whsett JA, Nakata K. Pulmonary alveolar proteos. N Engl J Med. 2003 Dec 25;349(26):2527-39. do 10.1056/NEJMra023226. No abstract avaable.
Carey B, Trapnell BC. The molecular bas of pulmonary alveolar proteos. Cl munol. 2010 May;135(2):223-35. do 10.1016/j.cl.2010.02.017. Epub 2010 Mar 25.
Ucha K, Nakata K, Carey B, Chalk C, SuzukT, SakagamT, Koch DE, Stevens C, oue Y, Yamada Y, Trapnell BC. Standarded serum GM-CSF autoantody testg for the route clal dgnos of automune pulmonary alveolar proteos. J munol Methods. 2014 Jan 15;402(1-2):57-70. do 10.1016/j.j.2013.11.011. Epub 2013 Nov 23.
The Longitudinal Evaluation of Autoimmune Pulmonary Alveolar Proteinosis

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03531996Test

المصدر: An Open-label, Non-controlled, Multicentre Clinical Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis Patients

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03482752Test

المصدر: First in Human Study of Pioglitazone Therapy of Autoimmune Pulmonary Alveolar Proteinosis

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03231033Test

المؤلفون: Rare Diseases Clinical Research Network, National Center for Advancing Translational Sciences (NCATS)

المصدر: Evaluation of a Single Dose of Inhaled Sargramostim in Patients With Autoimmune Pulmonary Alveolar Proteinosis

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03006146Test

المؤلفون: Agenzia Italiana del Farmaco

المساهمون: Ilaria Campo, Study coordinator

المصدر: Trapnell BC, Whsett JA, Nakata K. Pulmonary alveolar proteos. N Engl J Med. 2003 Dec 25;349(26):2527-39. do 10.1056/NEJMra023226. No abstract avaable.
Beccar M, LuettM, RodG, Corso A, Zo MC, Colato S, PochettP, BraschA, PozzE, Cerver Long-term durable benef after whole lung lavage pulmonary alveolar proteos. Eur Resp J. 2004 Apr;23(4):526-31. do 10.1183/09031936.04.00102704.
Wylam ME, Ten R, Prakash UB, Nadrous HF, Clawson ML, Anderson PM. Aerosol granulocyte-macrophage colony-stulatg factor for pulmonary alveolar proteos. Eur Resp J. 2006 Mar;27(3):585-93. do 10.1183/09031936.06.00058305.
Trapnell BC, oue Y, Bonella F, Morgan C, Jouneau S, Bendstrup E, Campo Pap SA, YamaguchE, Cetkaya E, kovh MM, Kramer MR, Veltkamp M, Kreuter M, Baba T, Ganslandt C, Tarnow Waterer G, Jouhaen T; PALA Trl vestators. haled Molgramost Therapy Automune Pulmonary Alveolar Proteos. N Engl J Med. 2020 Oct 22;383(17):1635-1644. do 10.1056/NEJMoa1913590. Epub 2020 Sep 7.
Tazawa R, Ueda T, Abe M, TatsumK, Eda R, Kondoh S, Moroto K, Tanaka T, YamaguchE, TakahashA, Oda M, h H, umS, Sugama H, Nakagawa A, Tom K, SuzukM, Konno S, OhkouchS, Tode N, Handa T, HaT, oue Y, AraT, Asakawa K, SakagamT, Hashoto A, Tanaka T, Takada T, MamA, Kamura N, Nakata K. haled GM-CSF for Pulmonary Alveolar Proteos. N Engl J Med. 2019 Sep 5;381(10):923-932. do 10.1056/NEJMoa1816216.
Inhaled GM-CSF Reduces the Need for Whole Lung Lavage and Improves Gas Exchange in Autoimmune PAP Patients

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00901511Test

المؤلفون: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

المساهمون: Kaifeng Xu, MD

المصدر: A Prospective Study of Inhaling Granulocyte-macrophage Colony Stimulating Factor in Adult Patients With Mild-to-moderate Autoimmune Pulmonary Alveolar Proteinosis in China: a Randomized Open-label Study

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT02243228Test