صورة
Image_1_CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function.tif
| العنوان: | Image_1_CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function.tif |
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| المؤلفون: | André J. Esgalhado, Débora Reste-Ferreira, Stephanie E. Albino, Adriana Sousa, Ana Paula Amaral, António Martinho, Isabel T. Oliveira, Ignacio Verde, Olga Lourenço, Ana M. Fonseca, Elsa M. Cardoso, Fernando A. Arosa |
| سنة النشر: | 2020 |
| المجموعة: | Frontiers: Figshare |
| مصطلحات موضوعية: | Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, effector-memory CD8+ T cells, elderly, brain cognition, HLA class I, healthy aging, CD4+ IFNγ+ |
| الوصف: | There is increasing evidence that in humans the adaptive immunological system can influence cognitive functions of the brain. We have undertaken a comprehensive immunological analysis of lymphocyte and monocyte populations as well as of HLA molecules expression in a cohort of elderly volunteers (age range, 64–101) differing in their cognitive status. Hereby, we report on the identification of a novel signature in cognitively impaired elderly characterized by: (1) elevated percentages of CD8+ T effector-memory cells expressing high levels of the CD45RA phosphate receptor (Temra hi ); (2) high percentages of CD8+ T cells expressing high levels of the CD8β chain (CD8β hi ); (3) augmented production of IFNγ by in vitro activated CD4+ T cells. Noteworthy, CD3+CD8+ Temra hi and CD3+CD8β hi cells were associated with impaired cognition. Cytomegalovirus seroprevalence showed that all volunteers studied but one were CMV positive. Finally, we show that some of these phenotypic and functional features are associated with an increased frequency of the HLA-B8 serotype, which belongs to the ancestral haplotype HLA-A1, Cw7, B8, DR3, DQ2, among cognitively impaired volunteers. To our knowledge, this is the first proof in humans linking the amount of cell surface CD45RA and CD8β chain expressed by CD8+ Temra cells, and the amount of IFNγ produced by in vitro activated CD4+ T cells, with impaired cognitive function in the elderly. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/figure/Image_1_CD45RA_CD8_and_IFN_Are_Potential_Immune_Biomarkers_of_Human_Cognitive_Function_tif/13284563Test |
| DOI: | 10.3389/fimmu.2020.592656.s001 |
| الإتاحة: | https://doi.org/10.3389/fimmu.2020.592656.s001Test https://figshare.com/articles/figure/Image_1_CD45RA_CD8_and_IFN_Are_Potential_Immune_Biomarkers_of_Human_Cognitive_Function_tif/13284563Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.FC104E43 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2020.592656.s001 |
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