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1صورة
المؤلفون: Prapaporn Chaniad, Arisara Phuwajaroanpong, Walaiporn Plirat, Atthaphon Konyanee, Abdi Wira Septama, Chuchard Punsawad
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Science Policy, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tetrazolium salt method, new drug candidates, methoxyphenyl )- 4h, lactate dehydrogenase enzyme, hepg2 cells using, div >< p, commonly found compound, significant problem worldwide, ms analysis revealed, highest suppressive effect, greatest suppressive effect, antimalarial drug resistance, 94 %) testing, highest antimalarial activity, antimalarial activity using, oleic acid amide, pscd formulations exhibiting, pscd formulations demonstrated, acute oral toxicity, whereas ethyl 4
الوصف: PSCD, Pra-Sa-Chan-Dang; gas chromatography-mass spectrometry.
الإتاحة: https://doi.org/10.1371/journal.pone.0296756.g002Test
https://figshare.com/articles/figure/Chromatogram_of_ethanolic_extract_of_PSCD_formulation_from_GC-MS_analysis_/24983995Test -
2صورة
المؤلفون: Prapaporn Chaniad, Arisara Phuwajaroanpong, Walaiporn Plirat, Atthaphon Konyanee, Abdi Wira Septama, Chuchard Punsawad
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Science Policy, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tetrazolium salt method, new drug candidates, methoxyphenyl )- 4h, lactate dehydrogenase enzyme, hepg2 cells using, div >< p, commonly found compound, significant problem worldwide, ms analysis revealed, highest suppressive effect, greatest suppressive effect, antimalarial drug resistance, 94 %) testing, highest antimalarial activity, antimalarial activity using, oleic acid amide, pscd formulations exhibiting, pscd formulations demonstrated, acute oral toxicity, whereas ethyl 4
الوصف: RT, retention time; MW, molecular weight; CTLL, Chan-Ta-Lee-La; GC-MS, gas chromatography-mass spectrometry.
الإتاحة: https://doi.org/10.1371/journal.pone.0296756.g001Test
https://figshare.com/articles/figure/Chromatogram_of_ethanolic_extract_of_CTLL_formulation_from_GC-MS_analysis_/24983992Test -
3صورة
المؤلفون: Kohei Miyake, Satoru Senoo, Ritsuya Shiiba, Junko Itano, Goro Kimura, Tatsuyuki Kawahara, Tomoki Tamura, Kenichiro Kudo, Tetsuji Kawamura, Yasuharu Nakahara, Hisao Higo, Daisuke Himeji, Nagio Takigawa, Nobuaki Miyahara
مصطلحات موضوعية: Medicine, Cell Biology, Molecular Biology, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, retrospective cohort study, optimal cutoff point, lower serum albumin, lower lymphocyte count, human immunodeficiency virus, higher lactate dehydrogenase, developing pneumocystis pneumonia, appropriate prophylaxis especially, pneumocystis jirovecii <, logistic regression analysis, past immunosuppressant use, odds ratio 1, 16 – 1, underlying autoimmune disease, identify risk factors, past steroid dose, associated lower mortality, term steroid use
الوصف: Objective Long-term steroid use increases the risk of developing Pneumocystis pneumonia (PcP), but there are limited reports on the relation of long-term steroid and PcP mortality. Methods Retrospective multicenter study to identify risk factors for PcP mortality, including average steroid dose before the first visit for PcP in non-human immunodeficiency virus (HIV)-PcP patients. We generated receiver operating characteristic (ROC) curves for 90-day all-cause mortality and the mean daily steroid dose per unit body weight in the preceding 10 to 90 days in 10-day increments. Patients were dichotomized by 90-day mortality and propensity score-based stabilized inverse probability of treatment weighting (IPTW) adjusted covariates of age, sex, and underlying disease. Multivariate analysis with logistic regression assessed whether long-term corticosteroid use affected outcome. Results Of 133 patients with non-HIV-PcP, 37 died within 90 days of initial diagnosis. The area under the ROC curve for 1–40 days was highest, and the optimal cutoff point of median adjunctive corticosteroid dosage was 0.34 mg/kg/day. Past steroid dose, underlying interstitial lung disease and emphysema, lower serum albumin and lower lymphocyte count, higher lactate dehydrogenase, use of therapeutic pentamidine and therapeutic high-dose steroids were all significantly associated with mortality. Underlying autoimmune disease, past immunosuppressant use, and a longer time from onset to start of treatment, were associated lower mortality. Logistic regression analysis after adjusting for age, sex, and underlying disease with IPTW revealed that steroid dose 1–40 days before the first visit for PcP (per 0.1 mg/kg/day increment, odds ratio 1.36 [95% confidence interval = 1.16–1.66], P <0.001), low lymphocyte counts, and high lactate dehydrogenase revel were independent mortality risk factor, while respiratory failure, early steroid, and sulfamethoxazole/trimethoprim for PcP treatment did not. Conclusion A steroid dose before PcP onset was strongly ...
الإتاحة: https://doi.org/10.1371/journal.pone.0292507.g001Test
https://figshare.com/articles/figure/Patient_selection_flowchart_/25191817Test -
4صورة
المؤلفون: Kohei Miyake, Satoru Senoo, Ritsuya Shiiba, Junko Itano, Goro Kimura, Tatsuyuki Kawahara, Tomoki Tamura, Kenichiro Kudo, Tetsuji Kawamura, Yasuharu Nakahara, Hisao Higo, Daisuke Himeji, Nagio Takigawa, Nobuaki Miyahara
مصطلحات موضوعية: Medicine, Cell Biology, Molecular Biology, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, retrospective cohort study, optimal cutoff point, lower serum albumin, lower lymphocyte count, human immunodeficiency virus, higher lactate dehydrogenase, developing pneumocystis pneumonia, appropriate prophylaxis especially, pneumocystis jirovecii <, logistic regression analysis, past immunosuppressant use, odds ratio 1, 16 – 1, underlying autoimmune disease, identify risk factors, past steroid dose, associated lower mortality, term steroid use
الوصف: ROC curve analysis showing the performance of past 40 days corticosteroid dose before PcP first visit in predicting all-cause 90-day mortality of non-HIV-PcP patients.
الإتاحة: https://doi.org/10.1371/journal.pone.0292507.g002Test
https://figshare.com/articles/figure/ROC_AUC_analysis_/25191820Test -
5صورة
المؤلفون: Kohei Miyake, Satoru Senoo, Ritsuya Shiiba, Junko Itano, Goro Kimura, Tatsuyuki Kawahara, Tomoki Tamura, Kenichiro Kudo, Tetsuji Kawamura, Yasuharu Nakahara, Hisao Higo, Daisuke Himeji, Nagio Takigawa, Nobuaki Miyahara
مصطلحات موضوعية: Medicine, Cell Biology, Molecular Biology, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, retrospective cohort study, optimal cutoff point, lower serum albumin, lower lymphocyte count, human immunodeficiency virus, higher lactate dehydrogenase, developing pneumocystis pneumonia, appropriate prophylaxis especially, pneumocystis jirovecii <, logistic regression analysis, past immunosuppressant use, odds ratio 1, 16 – 1, underlying autoimmune disease, identify risk factors, past steroid dose, associated lower mortality, term steroid use
الوصف: 90-day mortality by category of mean steroid load 1–40 days before first visit.
الإتاحة: https://doi.org/10.1371/journal.pone.0292507.g003Test
https://figshare.com/articles/figure/90-day_mortality_by_category_of_mean_steroid_load_1_40_days_before_first_visit_/25191823Test -
6صورة
المؤلفون: Kohei Miyake, Satoru Senoo, Ritsuya Shiiba, Junko Itano, Goro Kimura, Tatsuyuki Kawahara, Tomoki Tamura, Kenichiro Kudo, Tetsuji Kawamura, Yasuharu Nakahara, Hisao Higo, Daisuke Himeji, Nagio Takigawa, Nobuaki Miyahara
مصطلحات موضوعية: Medicine, Cell Biology, Molecular Biology, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, retrospective cohort study, optimal cutoff point, lower serum albumin, lower lymphocyte count, human immunodeficiency virus, higher lactate dehydrogenase, developing pneumocystis pneumonia, appropriate prophylaxis especially, pneumocystis jirovecii <, logistic regression analysis, past immunosuppressant use, odds ratio 1, 16 – 1, underlying autoimmune disease, identify risk factors, past steroid dose, associated lower mortality, term steroid use
الوصف: Objective Long-term steroid use increases the risk of developing Pneumocystis pneumonia (PcP), but there are limited reports on the relation of long-term steroid and PcP mortality. Methods Retrospective multicenter study to identify risk factors for PcP mortality, including average steroid dose before the first visit for PcP in non-human immunodeficiency virus (HIV)-PcP patients. We generated receiver operating characteristic (ROC) curves for 90-day all-cause mortality and the mean daily steroid dose per unit body weight in the preceding 10 to 90 days in 10-day increments. Patients were dichotomized by 90-day mortality and propensity score-based stabilized inverse probability of treatment weighting (IPTW) adjusted covariates of age, sex, and underlying disease. Multivariate analysis with logistic regression assessed whether long-term corticosteroid use affected outcome. Results Of 133 patients with non-HIV-PcP, 37 died within 90 days of initial diagnosis. The area under the ROC curve for 1–40 days was highest, and the optimal cutoff point of median adjunctive corticosteroid dosage was 0.34 mg/kg/day. Past steroid dose, underlying interstitial lung disease and emphysema, lower serum albumin and lower lymphocyte count, higher lactate dehydrogenase, use of therapeutic pentamidine and therapeutic high-dose steroids were all significantly associated with mortality. Underlying autoimmune disease, past immunosuppressant use, and a longer time from onset to start of treatment, were associated lower mortality. Logistic regression analysis after adjusting for age, sex, and underlying disease with IPTW revealed that steroid dose 1–40 days before the first visit for PcP (per 0.1 mg/kg/day increment, odds ratio 1.36 [95% confidence interval = 1.16–1.66], P <0.001), low lymphocyte counts, and high lactate dehydrogenase revel were independent mortality risk factor, while respiratory failure, early steroid, and sulfamethoxazole/trimethoprim for PcP treatment did not. Conclusion A steroid dose before PcP onset was strongly ...
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7صورة
المؤلفون: Kohei Miyake, Satoru Senoo, Ritsuya Shiiba, Junko Itano, Goro Kimura, Tatsuyuki Kawahara, Tomoki Tamura, Kenichiro Kudo, Tetsuji Kawamura, Yasuharu Nakahara, Hisao Higo, Daisuke Himeji, Nagio Takigawa, Nobuaki Miyahara
مصطلحات موضوعية: Medicine, Cell Biology, Molecular Biology, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, retrospective cohort study, optimal cutoff point, lower serum albumin, lower lymphocyte count, human immunodeficiency virus, higher lactate dehydrogenase, developing pneumocystis pneumonia, appropriate prophylaxis especially, pneumocystis jirovecii <, logistic regression analysis, past immunosuppressant use, odds ratio 1, 16 – 1, underlying autoimmune disease, identify risk factors, past steroid dose, associated lower mortality, term steroid use
الوصف: ROC curve analysis showing the performance of past 40 days corticosteroid dose before PcP first visit in predicting all-cause 90-day mortality of non-HIV-PcP patients.
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8صورة
المؤلفون: Kohei Miyake, Satoru Senoo, Ritsuya Shiiba, Junko Itano, Goro Kimura, Tatsuyuki Kawahara, Tomoki Tamura, Kenichiro Kudo, Tetsuji Kawamura, Yasuharu Nakahara, Hisao Higo, Daisuke Himeji, Nagio Takigawa, Nobuaki Miyahara
مصطلحات موضوعية: Medicine, Cell Biology, Molecular Biology, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, retrospective cohort study, optimal cutoff point, lower serum albumin, lower lymphocyte count, human immunodeficiency virus, higher lactate dehydrogenase, developing pneumocystis pneumonia, appropriate prophylaxis especially, pneumocystis jirovecii <, logistic regression analysis, past immunosuppressant use, odds ratio 1, 16 – 1, underlying autoimmune disease, identify risk factors, past steroid dose, associated lower mortality, term steroid use
الوصف: 90-day mortality by category of mean steroid load 1–40 days before first visit.
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9صورة
المؤلفون: Mubashir Aziz, Muhammad Sarfraz, Muhammad Khurrum Ibrahim, Syeda Abida Ejaz, Tasneem Zehra, Hanan A. Ogaly, Mosab Arafat, Fatimah A. M. Al-Zahrani, Chen Li
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, significant global cause, potent bioactive agents, particularly potent candidate, one strategic avenue, lactate dehydrogenase release, imparting significant insights, amidst ongoing efforts, employed computational techniques, computational analyses suggest, molecular dynamics simulations, including molecular docking, 3 activity assays, hydroxyacetyl )- 4, 6s )- 4, promising anticancer candidates, via caspase 3, study 8217, knowledge holds potential, demonstrated marked efficacy
الوصف: Data represent the mean ± SD (n = 3). * p < 0.05 compares the treated cell with control cell.
الإتاحة: https://doi.org/10.1371/journal.pone.0292455.g003Test
https://figshare.com/articles/figure/Detection_of_Caspase-3_activity_was_detected_in_HeLa_MDA-MB231_and_MCF-7_cells_treated_at_two_different_concentrations_respectively_for_24_h_using_Caspase-3_Assay_Kit_Fluorometric_ab39383_/24890221Test -
10صورة
المؤلفون: Mubashir Aziz, Muhammad Sarfraz, Muhammad Khurrum Ibrahim, Syeda Abida Ejaz, Tasneem Zehra, Hanan A. Ogaly, Mosab Arafat, Fatimah A. M. Al-Zahrani, Chen Li
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, significant global cause, potent bioactive agents, particularly potent candidate, one strategic avenue, lactate dehydrogenase release, imparting significant insights, amidst ongoing efforts, employed computational techniques, computational analyses suggest, molecular dynamics simulations, including molecular docking, 3 activity assays, hydroxyacetyl )- 4, 6s )- 4, promising anticancer candidates, via caspase 3, study 8217, knowledge holds potential, demonstrated marked efficacy
الوصف: Illustration of 2D and 3D interaction of A02 against NF-κB.
الإتاحة: https://doi.org/10.1371/journal.pone.0292455.g011Test
https://figshare.com/articles/figure/Illustration_of_2D_and_3D_interaction_of_A02_against_NF-_B_/24890245Test