التفاصيل البيبلوغرافية
| العنوان: |
Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma |
| المؤلفون: |
Qing, Kai, Jin, Zhen, Fu, Wanbin, Wang, Wenfang, Liu, Zhao, Li, Xiaoyang, Xu, Zizhen, Li, Junmin |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2016 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Diffuse large B cell lymphoma, Oridonin, NVP-BEZ235, Apoptosis, PI3K/mTOR, NF-kB |
| الوصف: |
We demonstrate the synergistic antitumor effect of oridonin and the PI3K/mTOR inhibitor NVP-BEZ235 on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma (non-GCB DLBCL) both in vitro and in vivo. The underlying mechanism may be multifunctional, involving apoptosis, AKT/mTOR and NF-kB inactivation, and ROS-mediated DNA damage response. Our findings pave the way for a new potential treatment option for non-GCB DLBCL with the combination of oridonin and NVP-BEZ235. |
| نوع الوثيقة: |
other non-article part of journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://www.jhoonline.org/content/9/1/72Test |
| الإتاحة: |
http://www.jhoonline.org/content/9/1/72Test |
| حقوق: |
Copyright 2016 The Author(s). |
| رقم الانضمام: |
edsbas.5FC77403 |
| قاعدة البيانات: |
BASE |
