أخبار
2A to the Fore - Research, Technology and Applications
| العنوان: | 2A to the Fore - Research, Technology and Applications |
|---|---|
| المؤلفون: | Luke, Garry A., Escuin, Helena, De Felipe, Pablo, Ryan, Martin D. |
| المساهمون: | Harding, Stephen |
| المصدر: | Luke , G A , Escuin , H , De Felipe , P & Ryan , M D 2009 , 2A to the Fore - Research, Technology and Applications . in S Harding (ed.) , Biotechnology and Genetic Engineering Reviews . vol. 26 , Nottingham University Press , Loughborough , pp. 223-260 . https://doi.org/10.5661/bger-26-223Test |
| بيانات النشر: | Nottingham University Press |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | MOUTH-DISEASE VIRUS, PICORNA-LIKE-VIRUS, COMPLETE NUCLEOTIDE-SEQUENCE, PLURIPOTENT STEM-CELLS, GROUP-C ROTAVIRUS, SIGNAL RECOGNITION PARTICLE, ENZYME-REPLACEMENT THERAPY, GREEN FLUORESCENT PROTEIN, DEPENDENT RNA-POLYMERASES, RECEPTOR RETROGENIC MICE |
| الوصف: | The 2A region of the foot-and-mouth disease virus (FMDV) encodes a short sequence that mediates self-processing by a novel translational effect. Translation elongation arrest leads to release of the nascent polypeptide and re-initiation at the next in-frame codon. In this way discrete translation products are derived from a single open reading frame. Active 2A-like sequences have been found in (many) other viruses and trypanosome non-LTR retrotransposons. Exponential growth of 2A technology within the last decade has lead to many biotechnological/biomedical applications including the generation of transgenic plants/animals and genetic manipulation of human embryonic stem cells (hESCs). |
| نوع الوثيقة: | other non-article part of journal/newspaper |
| اللغة: | English |
| DOI: | 10.5661/bger-26-223 |
| الإتاحة: | https://doi.org/10.5661/bger-26-223Test https://risweb.st-andrews.ac.uk/portal/en/researchoutput/2a-to-the-fore--research-technology-and-applicationsTest(d1368079-1d7e-43b4-a36a-705a2b11d3dd).html |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.A0F98993 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5661/bger-26-223 |
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