التفاصيل البيبلوغرافية
| العنوان: |
Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium |
| المؤلفون: |
Abdollahi-Roodsaz, Shahla, van de Loo, Fons AJ, van den Berg, Wim B |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2011 |
| المجموعة: |
BioMed Central |
| الوصف: |
Synovial tissue of patients with rheumatoid arthritis (RA) spontaneously produces several cytokines, of which a fundamental role in joint inflammation and destruction has been established. However, the factors sustaining this phenomenon remain poorly understood. In a recent report, blockade of Toll-like receptor 2 (TLR2) was found to inhibit the spontaneous release of inflammatory cytokines by intact RA synovial explant cultures. Adding to the recent evidence implicating other TLRs (in particular, TLR4), this observation highlights the potential of TLRs as therapeutic targets to suppress the local production of multiple cytokines and to control the chronic inflammatory loop in RA. |
| نوع الوثيقة: |
other non-article part of journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://arthritis-research.com/content/13/2/105Test |
| الإتاحة: |
http://arthritis-research.com/content/13/2/105Test |
| حقوق: |
Copyright 2011 BioMed Central Ltd |
| رقم الانضمام: |
edsbas.927A1ADF |
| قاعدة البيانات: |
BASE |
