التفاصيل البيبلوغرافية
| العنوان: |
Influence of integrated molecular pathology test results on real-world management decisions for patients with pancreatic cysts: analysis of data from a national registry cohort |
| المؤلفون: |
Loren, David, Kowalski, Thomas, Siddiqui, Ali, Jackson, Sara, Toney, Nicole, Malhotra, Nidhi, Haddad, Nadim |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2016 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Endoscopic-ultrasound guided fine-needle aspiration, Integrated molecular pathology, Pancreatic cyst, Pancreatic neoplasm, Patient registry, Real-world management decisions, Sendai 2012 International consensus guideline |
| الوصف: |
Background Integrated molecular pathology (IMP) approaches based on DNA mutational profiling accurately determine pancreatic cyst malignancy risk in patients lacking definitive diagnoses following endoscopic ultrasound imaging with fine-needle aspiration of fluid for cytology. In such cases, IMP ‘low-risk’ and ‘high-risk’ diagnoses reliably predict benign and malignant disease, respectively, and provide improved risk stratification for malignancy than a model of the 2012 International Consensus Guideline (ICG) recommendations. Our objective was to determine if initial adjunctive IMP testing influenced future real-world pancreatic cyst management decisions for intervention or surveillance relative to ICG recommendations, and if this benefitted patient outcomes. Methods Analysis of data from the previously described National Pancreatic Cyst Registry. Associations between real-world decisions (intervention vs. surveillance), ICG model recommendations (surgery vs. surveillance) and IMP diagnoses (high-risk vs. low-risk) were evaluated using 2 × 2 tables. Kaplan Meier and hazard ratio analyses were used to assess time to malignancy. Odds ratios (OR) for surgery decision were determined using logistic regression. Results Of 491 patients, 206 received clinical intervention at follow-up (183 surgery, 4 chemotherapy, 19 presumed by malignant cytology). Overall, 13 % (66/491) of patients had a malignant outcome and 87 % (425/491) had a benign outcome at 2.9 years’ follow-up. When ICG and IMP were concordant for surveillance/surgery recommendations, 83 % and 88 % actually underwent surveillance or surgery, respectively. However, when discordant, IMP diagnoses were predictive of real-world decisions, with 88 % of patients having an intervention when ICG recommended surveillance but IMP indicated high risk, and 55 % undergoing surveillance when ICG recommended surgery but IMP indicated low risk. These IMP-associated management decisions benefitted patient outcomes in these subgroups, as 57 % had malignant and 99 % ... |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.diagnosticpathology.org/content/11/1/5Test |
| الإتاحة: |
http://www.diagnosticpathology.org/content/11/1/5Test |
| حقوق: |
Copyright 2016 Loren et al. |
| رقم الانضمام: |
edsbas.E95349DC |
| قاعدة البيانات: |
BASE |
