المؤلفون: Alvarenga, Patricia H., Alves e Silva, Thiago Luiz, Suzuki, Motoshi, Nardone, Glenn, Cecilio, Pedro, Vega-Rodriguez, Joel, Ribeiro, Jose M.C., Andersen, John F.

المصدر: Journal of Proteome Research; April 2024, Vol. 23 Issue: 4 p1471-1487, 17p

مستخلص: In arthropods, hemolymph carries immune cells and solubilizes and transports nutrients, hormones, and other molecules that are involved in diverse physiological processes including immunity, metabolism, and reproduction. However, despite such physiological importance, little is known about its composition. We applied mass spectrometry-based label-free quantification approaches to study the proteome of hemolymph perfused from sugar-fed female and male Aedes aegyptimosquitoes. A total of 1403 proteins were identified, out of which 447 of them were predicted to be extracellular. In both sexes, almost half of these extracellular proteins were predicted to be involved in defense/immune response, and their relative abundances (based on their intensity-based absolute quantification, iBAQ) were 37.9 and 33.2%, respectively. Interestingly, among them, 102 serine proteases/serine protease-homologues were identified, with almost half of them containing CLIP regulatory domains. Moreover, proteins belonging to families classically described as chemoreceptors, such as odorant-binding proteins (OBPs) and chemosensory proteins (CSPs), were also highly abundant in the hemolymph of both sexes. Our data provide a comprehensive catalogue of A. aegyptihemolymph basal protein content, revealing numerous unexplored targets for future research on mosquito physiology and disease transmission. It also provides a reference for future studies on the effect of blood meal and infection on hemolymph composition.

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Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D, Whincup, Peter H, Wichstrøm, Lars, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wild, Philipp S, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wirth, James P, Wojtyniak, Bogdan, Woldeyohannes, Meseret, Wolf, Kathrin, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Li, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, Yépez García, Martha, Yiallouros, Panayiotis K, Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, Yotov, Yoto, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zentai, Andrea, Zhang, Bing, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, Zuziak, Monika, Ezzati, Majid

المصدر: The Lancet; March 2024, Vol. 403 Issue: 10431 p1027-1050, 24p

مستخلص: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.

المؤلفون: Chen, Christopher H., Newman, Leannah N., Stark, Amanda P., Bond, Katherine E., Zhang, Dawei, Nardone, Stefano, Vanderburg, Charles R., Nadaf, Naeem M., Yao, Zhiyi, Mutume, Kefiloe, Flaquer, Isabella, Lowell, Bradford B., Macosko, Evan Z., Regehr, Wade G.

المصدر: Nature Neuroscience; November 2023, Vol. 26 Issue: 11 p1929-1941, 13p

مستخلص: In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety and affect. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly excites forebrain areas that contribute to such functions (including the amygdala, basal forebrain and septum), but that the classic cerebellar outputs, the deep cerebellar nuclei, do not directly project there. We show that PCs directly inhibit parabrachial nuclei (PBN) neurons that project to numerous forebrain regions. Suppressing the PC–PBN pathway influences many regions in the forebrain and is aversive. Molecular profiling shows that PCs directly inhibit numerous types of PBN neurons that control diverse behaviors that are not involved in motor control. Therefore, the PC–PBN pathway allows the cerebellum to directly regulate activity in the forebrain, and may be an important substrate for cerebellar disorders arising from damage to the posterior vermis.

المؤلفون: Nucera, Bruna, Rinaldi, Fabrizio, Flore, Davide, Panebianco, Luca, Bratti, Arianna, Ferraiuolo, Imma, Nardone, Raffaele, Brigo, Francesco

المصدر: Epileptic Disorders; October 2023, Vol. 25 Issue: 5 p791-794, 4p

مستخلص: Content available: Video.

المؤلفون: Tursi, Antonio, Piovani, Daniele, Brandimarte, Giovanni, Mario, Francesco, Elisei, Walter, Picchio, Marcello, Allegretta, Leonardo, Annunziata, Maria Laura, Bafutto, Mauro, Bassotti, Gabrio, Bianco, Maria Antonia, Colucci, Raffaele, Conigliaro, Rita, Dumitrascu, Dan L., Escalante, Ricardo, Ferrini, Luciano, Forti, Giacomo, Franceschi, Marilisa, Graziani, Maria Giovanna, Lammert, Frank, Latella, Giovanni, Maconi, Giovanni, Compare, Debora, Nardone, Gerardo, Camara De Castro Oliveira, Lucia, Oliveira, Enio Chaves, Papa, Alfredo, Papagrigoriadis, Savvas, Pietrzak, Anna, Pontone, Stefano, Poskus, Tomas, Pranzo, Giuseppe, Reichert, Matthias Christian, Rodinò, Stefano, Regula, Jaroslaw, Scaccianoce, Giuseppe, Scaldaferri, Franco, Vassallo, Roberto, Zampaletta, Costantino, Zullo, Angelo, Spaziani, Erasmo, Bonovas, Stefanos, Danese, Silvio, Astegiano, Marco, Bachetti, Francesco, Baldassarre, Gianluca, Baldi, Fabio, Borsotti, Edoardo, Cassieri, Claudio, Cazzato, Alessia, Chiri, Stefania, Ciccone, Antonio, Damiani, Alberto, Colibus, Patrizia De, Faggiani, Roberto, Finocchiaro, Fabio, Fiorella, Serafina, Foschia, Francesca, Furfaro, Federica, Gallina, Sara, Giorgetti, Gian Marco, Grad, Simona, Grande, Giuseppe, Grandolfo, Antonio, Lai, Maria Antonia, Lecca, Piera Giuseppina, Lisi, Daniele, Lopetuso, Loris Riccardo, Penna, Antonio, Pigò, Flavia, Portincasa, Piero, Rizzatti, Giannenrico, Rizzo, Giovanni Luca, Scanni, Stefania, Schiffino, Luigi, Stundiene, Ieva, Tesoriere, Antonino, Urgesi, Riccardo, Usai, Paolo

المصدر: United European Gastroenterology Journal; September 2023, Vol. 11 Issue: 7 p642-653, 12p

مستخلص: The Diverticular Inflammation and Complication Assessment (DICA) classification and the Combined Overview on Diverticular Assessment (CODA) were found to be effective in predicting the outcomes of Diverticular Disease (DD). We ascertain whether fecal calprotectin (FC) can further aid in improving risk stratification. A three‐year international, multicentre, prospective cohort study was conducted involving 43 Gastroenterology and Endoscopy centres. Survival methods for censored observations were used to estimate the risk of acute diverticulitis (AD) in newly diagnosed DD patients according to basal FC, DICA, and CODA. The net benefit of management strategies based on DICA, CODA and FC in addition to CODA was assessed with decision curve analysis, which incorporates the harms and benefits of using a prognostic model for clinical decisions. At the first diagnosis of diverticulosis/DD, 871 participants underwent FC measurement. FC was associated with the risk of AD at 3 years (HR per each base 10 logarithm increase: 3.29; 95% confidence interval, 2.13–5.10) and showed moderate discrimination (c‐statistic: 0.685; 0.614–0.756). DICA and CODA were more accurate predictors of AD than FC. However, FC showed high discrimination capacity to predict AD at 3 months, which was not maintained at longer follow‐up times. The decision curve analysis comparing the combination of FC and CODA with CODA alone did not clearly indicate a larger net benefit of one strategy over the other. FC measurement could be used as a complementary tool to assess the immediate risk of AD. In all other cases, treatment strategies based on the CODA score alone should be recommended.

المؤلفون: Rinaldi, Fabrizio, Nucera, Bruna, Bratti, Arianna, Flore, Davide, Ferraiuolo, Imma, Nardone, Raffaele, Brigo, Francesco

المصدر: Epileptic Disorders; August 2023, Vol. 25 Issue: 4 p575-579, 5p

مستخلص: Content available: Video

المؤلفون: Nardone, Olga Maria, Iacucci, Marietta, Villanacci, Vincenzo, Peyrin‐Biroulet, Laurent, Ghosh, Subrata, Danese, Silvio, Parigi, Tommaso Lorenzo

المصدر: United European Gastroenterology Journal; July 2023, Vol. 11 Issue: 6 p514-519, 6p

مستخلص: Treatment targets of ulcerative colitis (UC) have evolved to include not only endoscopic but also histologic remission. However, the concept of histological activity is still in its early days. We aimed to capture the attitudes toward UC histology and the uptake of standardized reporting of endoscopy and histology of UC in daily practice. We conducted a cross‐sectional survey of physicians involved in the care of inflammatory bowel disease worldwide. The survey included 21 questions divided into three sections. The first recorded demographics, specialty, and level of experience of participants; the second covered clinical practices and attitudes toward the use and reporting of endoscopy; and the third covered histology. In total, 359 participants from 60 countries and all levels of experience completed the survey. UC histology was used by nearly all respondents (90.5%) for initial diagnosis, by 72% to monitor disease course, by 62.4% to determine the microscopic extension, by 59.9% to confirm deep remission when considering to stop treatment, and 42.3% to increase/optimize treatment. Nevertheless 77.2% of participants reported that no standard histological index was available in their daily practice. Instead, endoscopy reports included the Mayo Endoscopic score in 90% of cases. The majority of respondents welcomed as useful or very useful an artificial intelligence system to automate scoring of endoscopy (69%) or histology (73%). UC histology reports are less standard than endoscopy reports, although most physicians consider histological activity useful when managing UC and would welcome artificial intelligence systems to automate endoscopic and histological scoring. This survey shows that most physicians consider histological disease activity when managing ulcerative colitis. Nevertheless, histological reports, unlike endoscopic reports, remain mainly descriptive despite recommendations from scientific societies to use validated scores. This is the first estimate of real‐world use of standard reporting in ulcerative colitis.

المؤلفون: Tortora, Raffaella, Farella, Nunzia, Morisco, Filomena, Coppola, Carmine, Izzo, Francesco, Salomone Megna, Angelo, Federico, Alessandro, Messina, Vincenzo, Nardone, Gerardo, Piai, Guido, Ragone, Enrico, Adinolfi, Luigi Elio, D’Adamo, Giuseppe, Stanzione, Maria, Francica, Giampiero, Torre, Pietro, De Girolamo, Vincenzo, Coppola, Nicola, Guarino, Maria, Dallio, Marcello, Rocco, Lucia, Di Costanzo, Giovan Giuseppe

المصدر: European Journal of Gastroenterology and Hepatology; July 2023, Vol. 35 Issue: 7 p734-741, 8p

المؤلفون: Principi, Mariabeatrice, Macaluso, Fabio Salvatore, Todeschini, Alessia, Facciotti, Federica, Contaldo, Antonella, Castiglione, Fabiana, Nardone, Olga Maria, Spagnuolo, Rocco, Doldo, Patrizia, Riguccio, Gaia, Conforti, Francesco Simone, Viganò, Chiara, Ascolani, Marta, Fiorino, Gionata, Correale, Carmen, Bodini, Giorgia, Milla, Monica, Scardino, Giulia, Vernero, Marta, Desideri, Federico, Caprioli, Flavio, Mannino, Mariella, Rizzo, Giuseppe, Orlando, Ambrogio

المصدر: European Journal of Gastroenterology and Hepatology; June 2023, Vol. 35 Issue: 6 p629-634, 6p

المؤلفون: Pierrat-Maury, N., Nardone, P., Civade, E., Laborde, C.

المصدر: Le Pharmacien Clinicien; June 2024, Vol. 59 Issue: 2 pe50-e51, 2p

مستخلص: Chez le patient parkinsonien, l’initiation de la pompe à apomorphine sous cutané (ASC) permet de lisser l’administration d’agoniste dopaminergique au cours de la journée et d’éviter les problèmes d’effet indésirable et d’absorption en lien avec la gastroparésie. La Levodopa Equivalent Dose(LED) est la dose de médicament parkinsonien ayant le même effet que 100mg de Levodopa à libération immédiate. Cet indicateur LED existe mais reste peut décrit dans la littérature aux différents moments du parcours de soin du parkinsonien.