المؤلفون: Roe, Matthew T., Armstrong, Paul W., Fox, Keith A. A., White, Harvey D., Prabhakaran, Dorairaj, Goodman, Shaun G., Cornel, Jan H., Bhatt, Deepak L., Clemmensen, Peter, Martinez, Felipe, Ardissino, Diego, Nicolau, Jose C., Boden, William E., Gurbel, Paul A., Ruzyllo, Witold, Dalby, Anthony J., McGuire, Darren K., Leiva-Pons, Jose L., Parkhomenko, Alexander, Gottlieb, Shmuel, Topacio, Gracita O., Hamm, Christian, Pavlides, Gregory, Goudev, Assen R., Oto, Ali, Tseng, Chuen-Den, Merkely, Bela, Gasparovic, Vladimir, Corbalan, Ramon, Cinteza, Mircea, McLendon, R. Craig, Winters, Kenneth J., Brown, Eileen B., Lokhnygina, Yuliya, Aylward, Philip E., Huber, Kurt, Hochman, Judith S., Ohman, E. Magnus

المساهمون: LANCELLOTTI, Patrizio

المصدر: New England Journal of Medicine, 367 (14), 1297-309 (2012)

مصطلحات موضوعية: Acute Coronary Syndrome/drug therapy, Aged, Angina, Unstable/drug therapy, Aspirin/therapeutic use, Cardiovascular Diseases/mortality/prevention & control, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Myocardial Infarction/drug therapy/epidemiology, Piperazines/adverse effects/therapeutic use, Platelet Aggregation Inhibitors/adverse effects/therapeutic use, Purinergic P2 Receptor Antagonists/adverse effects/therapeutic use, Stroke/epidemiology, Thiophenes/adverse effects/therapeutic use, Ticlopidine/adverse effects/analogs & derivatives/therapeutic use, Human health sciences, Cardiovascular & respiratory systems, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire

الوصف: BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel. RESULTS: At a median follow-up of 17 months, the primary end point of death from cardiovascular causes, myocardial infarction, or stroke among patients under the age of 75 years occurred in 13.9% of the prasugrel group and 16.0% of the clopidogrel group (hazard ratio in the prasugrel

العلاقة: urn:issn:0028-4793; urn:issn:1533-4406

الوصول الحر: https://orbi.uliege.be/handle/2268/151550Test

المؤلفون: Morgan, M., Enterline, D., Fukushima, T., McLendon, R., Cummings, T.

المصدر: Neuroradiology; December 2001, Vol. 43 Issue: 12 p1063-1066, 4p

مستخلص: Endodermal cysts are rare congenital intracranial lesions. Although histologically benign, they can become symptomatic as a result of mass effect and cause neurological deficits. We report a 30-year-old woman who presented with paresis of her right oculomotor nerve. Magnetic resonance imaging showed a 13×8-mm cystic lesion originating from the right oculomotor nerve at its exit from the mesencephalon. She underwent craniotomy, biopsy, slit resection, and drainage of the cyst. To our knowledge, endodermal cysts have not been previously described in relation to the oculomotor nerve.

المؤلفون: Gururangan, S, Cokgor, L, Rich, J N, Edwards, S, Affronti, M L, Quinn, J A, Herndon, J E, Provenzale, J M, McLendon, R E, Tourt-Uhlig, S, Sampson, J H, Stafford-Fox, V, Zaknoen, S, Early, M, Friedman, A H, Friedman, H S

المصدر: Neuro-Oncology; October 2001, Vol. 3 Issue: 4 p246-250, 5p

مستخلص: Both Gliadel wafers [1,3-bis(2-chloroethyl)-1-nitrosourea] and temozolomide (TEMO) have been shown in independent studies to prolong survival of patients with recurrent malignant glioma following surgery and radiotherapy. On the basis of preclinical evidence of synergism between Gliadel wafers and TEMO, a phase I study was designed to evaluate the toxicity of combining these 2 agents in the treatment of patients with recurrent supratentorial malignant glioma. All patients had surgical resection of the tumor at relapse, and up to 8 Gliadel (3.85%) wafers were placed in the surgical cavity following resection. Two weeks after surgery, TEMO was given orally daily for 5 days. Cohorts of 3 patients received TEMO at daily doses of 100 mg/m2, 150 mg/m2, and 200 mg/m2, respectively. Patients were assessed for toxicity 4 weeks after start of the first course of TEMO. Contrast-enhanced MRI of the brain was used to assesstumor response after the first cycle of TEMO. Patients with stable disease or response after the first cycle of TEMO were allowed to continue treatment at the same dose every 4 weeks for 12 cycles or until disease progression or unacceptable toxicity. Ten patients with a median age of 47 years (range, 22-66 years) were enrolled in this study. There were 7 patients with glioblastoma multiforme and 3 patients with anaplastic astrocytoma. Three patients were treated with TEMO at the first dose level of 100 mg/m2, 4 at the second dose level of 150 mg/m2, and 3 at the third dose level of 200 mg/m2. The 10 patients received a median of 3 cycles (range, 1-12 cycles) of TEMO following placement of Gliadel wafers. The treatment was well tolerated, with only 1 patient suffering grade III thrombocytopenia at the highest dose level. Two patients at each dose level had no evidence of disease progression after treatment. Four patients suffered progressive disease on therapy. Our study demonstrates that TEMO can be given safely after placement of Gliadel (3.85%) wafers. The recommended dosage for TEMO for a phase II study of this combination is 200 mg/m2 per day for 5 days.

المؤلفون: Bigner, S H, Rasheed, B K, Wiltshire, R, McLendon, R E

المصدر: Neuro-Oncology; January 1999, Vol. 1 Issue: 1 p52-60, 9p

مستخلص: Morphologic criteria for diagnosing oligodendrogliomas and for classifying them as well-differentiated (World Health Organization grade II) and anaplastic (World Health Organization grade III) are well recognized. Nevertheless, applying these guidelines to specific cases often reveals discrepancies among different observers. In addition, whether a given tumor also contains an astrocytic component may be debatable. Loss of heterozygosity studies have demonstrated that oligodendroglial neoplasms have a high incidence of loss of the 1p and 19q chromosomal arms. Although loss of heterozygosity for portions of 19q are sometimes seen in astrocytic neoplasms, these tumors seldom show complete loss of 19q accompanied by loss of 1p. Loss of 9p or homozygous deletion of the CDKN2 gene or both are associated with anaplastic oligodendrogliomas, whereas loss of 17p or TP53 gene mutations or both are frequent in astrocytomas, but rare in oligodendrogliomas. These observations suggest that molecular genetic parameters could provide an objective, reproducible framework for classifying oligodendroglial neoplasms.

المؤلفون: Lirng, J. F., Enterline, D. S., Tien, R. D., Fuchs, H., Friedman, H. S., Ellington, K. S., McLendon, R. R.

المصدر: Pediatric Radiology; November 1995, Vol. 25 Issue: Supplement 1 pS9-S13, 5p

مستخلص: We report two cases of papillary meningioma in children. The MRI appearance of this special type of meningioma is described for the first time. Both lesions were dura based and associated with cystic components. We review the literature pertaining to this type of meningioma and discuss the differential diagnosis of the MRI appearance. Because this is a malignant type of meningioma, early diagnosis and surgical intervention are important in the management of patients.

المؤلفون: McLendon, R. E., Archer, G. E., Garg, P. K., Bigner, D. D., Zalutsky, M. R.

المصدر: International Journal of Radiation, Oncology, Biology, Physics; 1996, Vol. 35 Issue: 1 p69-80, 12p

المؤلفون: Bigner, S. H., McLendon, R. E., Fuchs, H., McKeever, P. E., Friedman, H. S.

المصدر: Cancer Genetics and Cytogenetics; 1997, Vol. 97 Issue: 2 p125-134, 10p

المؤلفون: Pastan, I H, Archer, G E, McLendon, R E, Friedman, H S, Fuchs, H E, Wang, Q C, Pai, L H, Herndon, J, Bigner, D D

المصدر: Proceedings of the National Academy of Sciences of the United States of America; March 1995, Vol. 92 Issue: 7 p2765-2769, 5p

مستخلص: LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated from of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathecal space and cause neoplastic meningitis. We tested the therapeutic value of intrathecally administered LMB-7 by using a model of human neoplastic meningitis in athymic rats. This model is representative of a clinical situation in that antibody B3 cross-reacts with a number of normal tissues that can be used to monitor potential systemic toxicity. Treatment was begun 3 days after A431 tumor implantation. Without treatment, the animals median survival was 10 days. Intrathecal administration of 10 micrograms of LMB-7 in 40 microliters on days 3, 5, and 7 produced 4 of 10 and 8 of 10 long-term survivors (> 170 days) in two experiments. Of the long-term survivors, 2 of 4 and 7 of 8 survivors had no microscopic evidence of tumor and were considered histologic cures. Lack of significant toxicity in the effective dose range and specificity make LMB-7 an excellent candidate for intrathecal treatment of neoplastic meningitis in humans.

المؤلفون: Felsberg, G. J., Glass, J. P., Tien, R. D., McLendon, R.

المصدر: Neuroradiology; November 1996, Vol. 38 Issue: 8 p774-777, 4p

مستخلص: Abstract: Gliomatosis cerebri is a rare form of astrocytoma characterized by extreme infiltration of the brain structure in conjunction with a relative paucity of clinical findings. We describe the MRI findings in a patient with gliomatosis cerebri widely infiltrating the brain who presented with symptoms related to involvement of the optic nerves and chiasm. Contrast-enhanced MRI showed enlargement of the optic nerves and chiasm with pathological enhancement; T2-weighted images showed extensive infiltration of the brain by tumor. Histopathologic examination of the biopsy specimen showed anaplastic astrocytoma with gemistocytic predominance and a diagnosis of gliomatosis cerebri was reached.

المؤلفون: Sickles, D. W., McLendon, R. E., Rosenquist, Th. H.

المصدر: Histochemistry and Cell Biology; December 1982, Vol. 73 Issue: 4 p577-588, 12p

مستخلص: The present study examines the use of photographic densitometry combined with atomic absorption spectrophotometry for the quantitation of enzyme activities (SDH and ATPase) in fresh frozen sections of rat tibialis anterior muscles. The technique eliminates some difficulties which are inherent in other methods. The reliability of the technique was found to be in the 98% range; the results were precise for all samples studied. The use of SDH to separate muscle fibers into “types” was found to be totally inaccurate since a full spectrum of activities was observed. ATPase activities could separate easily into two groups, but a continuum of ATPase activities was observed in the fast-twitch fibers. The simultaneous use of both enzymes was capable of separating the FG, FOG and SO fibers; however, variation within a single type was considerable and a great deal of information was lost when using any classification system. The continuum of SDH activities indicates the motor units are arranged as a spectrum of fatigue-resistant contractile units. The range of ATPase activities observed is comparable to ranges of motor unit contraction times emphasizing the importance of this enzyme in the regulation of contraction speed.