Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study

التفاصيل البيبلوغرافية
العنوان: Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study
المؤلفون: Grinsztejn, Beatriz, Hughes, Michael D, Ritz, Justin, Salata, Robert, Mugyenyi, Peter, Hogg, Evelyn, Wieclaw, Linda, Gross, Robert, Godfrey, Catherine, Cardoso, Sandra W, Bukuru, Aggrey, Makanga, Mumbi, Faesen, Sharlaa, Mave, Vidya, Wangari Ndege, Beatrice, Nerette Fontain, Sandy, Samaneka, Wadzanai, Secours, Rode, van Schalkwyk, Marije, Mngqibisa, Rosie, Mohapi, Lerato, Valencia, Javier, Sugandhavesa, Patcharaphan, Montalban, Esmelda, Avihingsanon, Anchalee, Santos, Breno R, Kumarasamy, Nagalingeswaran, Kanyama, Cecilia, Schooley, Robert T, Mellors, John W, Wallis, Carole L, Collier, Ann C, Grinsztejn, B, Mugyenyi, PN, Collier, A, Salata, R, Godfrey, C, Hogg, E, Hughes, M, Ritz, J, Wieclaw, L, Sise, T, Mellors, JW, Wallis, C, Fletcher, CV, Gandhi, M, Gross, R, Schooley, RT, Walensky, R, van Schalkwyk, M, Faesen, S, Mngqibisa, R, Valencia, J, Montalban, E, Kumarasamy, N, Kanyama, C, Cardoso, SW, Santos, BR, Mansfield, B, Mugerwa, H, Ndege, BW, Secours, R, Samaneka, W, Kadam, D, Mave, V, Makanga, M, Fontain, SN, Sugandhavesa, P, Avihingsanon, A, Nakibuuka, L, Nassolo, H, Anthony, P, Kulkarni, V, Nsubuga, M, van Wyk, J, Rooney, J, van Delft, Y, Leavitt, R, Luk, R, Benns, A, Hovind, L, Shahkolahi, A
المصدر: The Lancet HIV; September 2019, Vol. 6 Issue: 9 pe588-e600, 13p
مستخلص: Antiretroviral therapy (ART) management is challenging for individuals in resource-limited settings presenting for third-line treatment because of complex resistance patterns, partly due to reduced access to viral load monitoring. We aimed to evaluate use of newer antiretroviral drugs and contemporary management approaches, including population-based sequencing, to select appropriate antiretrovirals, plasma viral load monitoring, and interventions to improve adherence in individuals presenting with second-line viral failure.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:24054704
23523018
DOI:10.1016/S2352-3018(19)30146-8